Tags

Type your tag names separated by a space and hit enter

Phytochemical Characterization and Bioactivity of Asparagus acutifolius: A Focus on Antioxidant, Cytotoxic, Lipase Inhibitory and Antimicrobial Activities.
Molecules. 2021 Jun 01; 26(11)M

Abstract

The phytochemical composition of leaves, stems, pericarps and rhizomes ethanolic extracts of Asparagus acutifolius were characterized by HPLC-DAD-MS. A. acutifolius samples contain at least eleven simple phenolics, one flavonon, two flavonols and six steroidal saponins. The stem extracts showed the highest total phenolic acid and flavonoid contents, where cafeic acid and rutin were the main compounds. No flavonoids were detected in the leaf, pericarp or rhizome while caffeic acid and ferulic acid were the predominant. Steroidal saponins were detected in the different plant parts of A. acutifolius, and the highest contents were found in the rhizome extracts. The stem extracts exhibited the highest antioxidant activity against 2,2-diphenyl-1-picrylhydrazyl (DPPH) and ferric reducing antioxidant power (FRAP) and the highest 2,2-azino-bis (3 ethylbenzothiazoline-6-sulphonic acid) (ABTS) scavenging activity was found in the pericarp extracts. The rhizome and leaf extracts showed a potent cytotoxic activity against HCT-116 and HepG2 cell lines. Moreover, the pericarp and rhizome extracts revealed a moderate lipase inhibitory activity. The leaf and rhizome extracts were screened for their antimicrobial activity against human pathogenic isolates. The leaf extract exhibited a powerful inhibitory activity against all the bacteria and fungi tested.

Authors+Show Affiliations

Phytochemicals and Food Quality Group, Instituto de la Grasa (CSIC), 41013 Seville, Spain. Unité de Physiologie et de Biochimie de la Réponse des Plantes aux Contraintes Abiotiques, FST Campus, Université Tunis El Manar, 1068 Tunis, Tunisia.Phytochemicals and Food Quality Group, Instituto de la Grasa (CSIC), 41013 Seville, Spain.Phytochemicals and Food Quality Group, Instituto de la Grasa (CSIC), 41013 Seville, Spain.Phytochemicals and Food Quality Group, Instituto de la Grasa (CSIC), 41013 Seville, Spain.Unité de Physiologie et de Biochimie de la Réponse des Plantes aux Contraintes Abiotiques, FST Campus, Université Tunis El Manar, 1068 Tunis, Tunisia.Unité de Physiologie et de Biochimie de la Réponse des Plantes aux Contraintes Abiotiques, FST Campus, Université Tunis El Manar, 1068 Tunis, Tunisia.Phytochemicals and Food Quality Group, Instituto de la Grasa (CSIC), 41013 Seville, Spain.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

34206066

Citation

Hamdi, Amel, et al. "Phytochemical Characterization and Bioactivity of Asparagus Acutifolius: a Focus On Antioxidant, Cytotoxic, Lipase Inhibitory and Antimicrobial Activities." Molecules (Basel, Switzerland), vol. 26, no. 11, 2021.
Hamdi A, Jaramillo-Carmona S, Rodríguez-Arcos R, et al. Phytochemical Characterization and Bioactivity of Asparagus acutifolius: A Focus on Antioxidant, Cytotoxic, Lipase Inhibitory and Antimicrobial Activities. Molecules. 2021;26(11).
Hamdi, A., Jaramillo-Carmona, S., Rodríguez-Arcos, R., Jiménez-Araujo, A., Lachaal, M., Karray-Bouraoui, N., & Guillén-Bejarano, R. (2021). Phytochemical Characterization and Bioactivity of Asparagus acutifolius: A Focus on Antioxidant, Cytotoxic, Lipase Inhibitory and Antimicrobial Activities. Molecules (Basel, Switzerland), 26(11). https://doi.org/10.3390/molecules26113328
Hamdi A, et al. Phytochemical Characterization and Bioactivity of Asparagus Acutifolius: a Focus On Antioxidant, Cytotoxic, Lipase Inhibitory and Antimicrobial Activities. Molecules. 2021 Jun 1;26(11) PubMed PMID: 34206066.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Phytochemical Characterization and Bioactivity of Asparagus acutifolius: A Focus on Antioxidant, Cytotoxic, Lipase Inhibitory and Antimicrobial Activities. AU - Hamdi,Amel, AU - Jaramillo-Carmona,Sara, AU - Rodríguez-Arcos,Rocío, AU - Jiménez-Araujo,Ana, AU - Lachaal,Mokhtar, AU - Karray-Bouraoui,Najoua, AU - Guillén-Bejarano,Rafael, Y1 - 2021/06/01/ PY - 2021/04/26/received PY - 2021/05/19/revised PY - 2021/05/24/accepted PY - 2021/7/2/entrez PY - 2021/7/3/pubmed PY - 2021/7/21/medline KW - Asparagus acutifolius KW - HPLC-DAD KW - HPLC/Q-TOF-MS KW - LC-MS KW - antimicrobial activity KW - antioxidant activity KW - cytotoxicity KW - lipase inhibitory activity KW - phytochemicals JF - Molecules (Basel, Switzerland) JO - Molecules VL - 26 IS - 11 N2 - The phytochemical composition of leaves, stems, pericarps and rhizomes ethanolic extracts of Asparagus acutifolius were characterized by HPLC-DAD-MS. A. acutifolius samples contain at least eleven simple phenolics, one flavonon, two flavonols and six steroidal saponins. The stem extracts showed the highest total phenolic acid and flavonoid contents, where cafeic acid and rutin were the main compounds. No flavonoids were detected in the leaf, pericarp or rhizome while caffeic acid and ferulic acid were the predominant. Steroidal saponins were detected in the different plant parts of A. acutifolius, and the highest contents were found in the rhizome extracts. The stem extracts exhibited the highest antioxidant activity against 2,2-diphenyl-1-picrylhydrazyl (DPPH) and ferric reducing antioxidant power (FRAP) and the highest 2,2-azino-bis (3 ethylbenzothiazoline-6-sulphonic acid) (ABTS) scavenging activity was found in the pericarp extracts. The rhizome and leaf extracts showed a potent cytotoxic activity against HCT-116 and HepG2 cell lines. Moreover, the pericarp and rhizome extracts revealed a moderate lipase inhibitory activity. The leaf and rhizome extracts were screened for their antimicrobial activity against human pathogenic isolates. The leaf extract exhibited a powerful inhibitory activity against all the bacteria and fungi tested. SN - 1420-3049 UR - https://www.unboundmedicine.com/medline/citation/34206066/Phytochemical_Characterization_and_Bioactivity_of_Asparagus_acutifolius:_A_Focus_on_Antioxidant_Cytotoxic_Lipase_Inhibitory_and_Antimicrobial_Activities_ L2 - https://www.mdpi.com/resolver?pii=molecules26113328 DB - PRIME DP - Unbound Medicine ER -