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Hydrogen Sulfide (H2S) and Polysulfide (H2Sn) Signaling: The First 25 Years.
Biomolecules. 2021 06 16; 11(6)B

Abstract

Since the first description of hydrogen sulfide (H2S) as a toxic gas in 1713 by Bernardino Ramazzini, most studies on H2S have concentrated on its toxicity. In 1989, Warenycia et al. demonstrated the existence of endogenous H2S in the brain, suggesting that H2S may have physiological roles. In 1996, we demonstrated that hydrogen sulfide (H2S) is a potential signaling molecule, which can be produced by cystathionine β-synthase (CBS) to modify neurotransmission in the brain. Subsequently, we showed that H2S relaxes vascular smooth muscle in synergy with nitric oxide (NO) and that cystathionine γ-lyase (CSE) is another producing enzyme. This study also opened up a new research area of a crosstalk between H2S and NO. The cytoprotective effect, anti-inflammatory activity, energy formation, and oxygen sensing by H2S have been subsequently demonstrated. Two additional pathways for the production of H2S with 3-mercaptopyruvate sulfurtransferase (3MST) from l- and d-cysteine have been identified. We also discovered that hydrogen polysulfides (H2Sn, n ≥ 2) are potential signaling molecules produced by 3MST. H2Sn regulate the activity of ion channels and enzymes, as well as even the growth of tumors. S-Sulfuration (S-sulfhydration) proposed by Snyder is the main mechanism for H2S/H2Sn underlying regulation of the activity of target proteins. This mini review focuses on the key findings on H2S/H2Sn signaling during the first 25 years.

Authors+Show Affiliations

Faculty of Pharmaceutical Sciences, Sanyo-Onoda City University, Yamaguchi 756-0884, Japan.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

34208749

Citation

Kimura, Hideo. "Hydrogen Sulfide (H2S) and Polysulfide (H2Sn) Signaling: the First 25 Years." Biomolecules, vol. 11, no. 6, 2021.
Kimura H. Hydrogen Sulfide (H2S) and Polysulfide (H2Sn) Signaling: The First 25 Years. Biomolecules. 2021;11(6).
Kimura, H. (2021). Hydrogen Sulfide (H2S) and Polysulfide (H2Sn) Signaling: The First 25 Years. Biomolecules, 11(6). https://doi.org/10.3390/biom11060896
Kimura H. Hydrogen Sulfide (H2S) and Polysulfide (H2Sn) Signaling: the First 25 Years. Biomolecules. 2021 06 16;11(6) PubMed PMID: 34208749.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hydrogen Sulfide (H2S) and Polysulfide (H2Sn) Signaling: The First 25 Years. A1 - Kimura,Hideo, Y1 - 2021/06/16/ PY - 2021/05/20/received PY - 2021/06/14/revised PY - 2021/06/14/accepted PY - 2021/7/2/entrez PY - 2021/7/3/pubmed PY - 2021/9/21/medline KW - 3MST KW - S-nitrosylation KW - S-sulfenylation KW - S-sulfuration KW - hydrogen peroxide KW - hydrogen sulfide KW - nitric oxide KW - polysulfides JF - Biomolecules JO - Biomolecules VL - 11 IS - 6 N2 - Since the first description of hydrogen sulfide (H2S) as a toxic gas in 1713 by Bernardino Ramazzini, most studies on H2S have concentrated on its toxicity. In 1989, Warenycia et al. demonstrated the existence of endogenous H2S in the brain, suggesting that H2S may have physiological roles. In 1996, we demonstrated that hydrogen sulfide (H2S) is a potential signaling molecule, which can be produced by cystathionine β-synthase (CBS) to modify neurotransmission in the brain. Subsequently, we showed that H2S relaxes vascular smooth muscle in synergy with nitric oxide (NO) and that cystathionine γ-lyase (CSE) is another producing enzyme. This study also opened up a new research area of a crosstalk between H2S and NO. The cytoprotective effect, anti-inflammatory activity, energy formation, and oxygen sensing by H2S have been subsequently demonstrated. Two additional pathways for the production of H2S with 3-mercaptopyruvate sulfurtransferase (3MST) from l- and d-cysteine have been identified. We also discovered that hydrogen polysulfides (H2Sn, n ≥ 2) are potential signaling molecules produced by 3MST. H2Sn regulate the activity of ion channels and enzymes, as well as even the growth of tumors. S-Sulfuration (S-sulfhydration) proposed by Snyder is the main mechanism for H2S/H2Sn underlying regulation of the activity of target proteins. This mini review focuses on the key findings on H2S/H2Sn signaling during the first 25 years. SN - 2218-273X UR - https://www.unboundmedicine.com/medline/citation/34208749/Hydrogen_Sulfide__H2S__and_Polysulfide__H2Sn__Signaling:_The_First_25_Years_ L2 - https://www.mdpi.com/resolver?pii=biom11060896 DB - PRIME DP - Unbound Medicine ER -