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Dietary fatty acids and risk for Alzheimer's disease, dementia, and mild cognitive impairment: A prospective cohort meta-analysis.
Nutrition. 2021 10; 90:111355.N

Abstract

The association between dietary fatty acid intake and Alzheimer's disease (AD), dementia, and mild cognitive impairment (MCI) risk is inconsistent. This meta-analysis examined the effect of dietary fatty acid intake in prospective cohort studies including patients with AD, dementia, and MCI. PubMed, China Biology Medicine (CBM), China National Knowledge Infrastructure (CNKI), Wanfang Data, and VIP Database were systematically searched through September 2020. The random-effects model was used to combine the highest and lowest categories of multivariable adjusted relative risk (RR). Prospective cohort studies that included associations between dietary fatty acid intake and the risk for AD, dementia, or MCI were included. Fourteen studies were included, comprising 54 177 participants: 1696 patients with AD, 1118 patients with dementia, and 2889 with MCI. The pooled RR showed a significant association only between ω-3 polyunsaturated fatty acid (PUFA) intake and MCI risk (RR, 0.86; 95% CI, 0.75-0.98), with no heterogeneity between studies (I2 = 0%). The intake of total fatty acids, saturated fatty acids (SFAs), cholesterol, monounsaturated fatty acids (MUFAs), PUFAs, ω-3 PUFAs, ω-6 PUFAs, docosahexaenoic acids (DHAs), and eicosapentaenoic acids (EPAs) was not significantly associated with AD risk. The intake of total fatty acids, SFAs, MUFAs, PUFAs, and ω-3 PUFAs was not significantly associated with dementia risk. This meta-analysis provided evidence that ω-3 PUFA intake may be negatively associated with MCI risk.

Authors+Show Affiliations

School of Public Health of Bengbu Medical College, Bengbu, China.School of Public Health of Bengbu Medical College, Bengbu, China.School of Public Health of Bengbu Medical College, Bengbu, China.School of Public Health of Bengbu Medical College, Bengbu, China.School of Public Health of Bengbu Medical College, Bengbu, China. Electronic address: zwh3104@sina.com.

Pub Type(s)

Journal Article
Meta-Analysis
Review

Language

eng

PubMed ID

34218119

Citation

Zhu, Run-Ze, et al. "Dietary Fatty Acids and Risk for Alzheimer's Disease, Dementia, and Mild Cognitive Impairment: a Prospective Cohort Meta-analysis." Nutrition (Burbank, Los Angeles County, Calif.), vol. 90, 2021, p. 111355.
Zhu RZ, Chen MQ, Zhang ZW, et al. Dietary fatty acids and risk for Alzheimer's disease, dementia, and mild cognitive impairment: A prospective cohort meta-analysis. Nutrition. 2021;90:111355.
Zhu, R. Z., Chen, M. Q., Zhang, Z. W., Wu, T. Y., & Zhao, W. H. (2021). Dietary fatty acids and risk for Alzheimer's disease, dementia, and mild cognitive impairment: A prospective cohort meta-analysis. Nutrition (Burbank, Los Angeles County, Calif.), 90, 111355. https://doi.org/10.1016/j.nut.2021.111355
Zhu RZ, et al. Dietary Fatty Acids and Risk for Alzheimer's Disease, Dementia, and Mild Cognitive Impairment: a Prospective Cohort Meta-analysis. Nutrition. 2021;90:111355. PubMed PMID: 34218119.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary fatty acids and risk for Alzheimer's disease, dementia, and mild cognitive impairment: A prospective cohort meta-analysis. AU - Zhu,Run-Ze, AU - Chen,Mei-Qing, AU - Zhang,Zhi-Wen, AU - Wu,Tian-Yu, AU - Zhao,Wen-Hong, Y1 - 2021/05/26/ PY - 2020/11/17/received PY - 2021/05/01/revised PY - 2021/05/16/accepted PY - 2021/7/5/pubmed PY - 2021/10/14/medline PY - 2021/7/4/entrez KW - Alzheimer's disease KW - Cohort studies KW - Dementia KW - Meta-analysis KW - Mild cognitive impairment KW - ω-3 polyunsaturated fatty acids SP - 111355 EP - 111355 JF - Nutrition (Burbank, Los Angeles County, Calif.) JO - Nutrition VL - 90 N2 - The association between dietary fatty acid intake and Alzheimer's disease (AD), dementia, and mild cognitive impairment (MCI) risk is inconsistent. This meta-analysis examined the effect of dietary fatty acid intake in prospective cohort studies including patients with AD, dementia, and MCI. PubMed, China Biology Medicine (CBM), China National Knowledge Infrastructure (CNKI), Wanfang Data, and VIP Database were systematically searched through September 2020. The random-effects model was used to combine the highest and lowest categories of multivariable adjusted relative risk (RR). Prospective cohort studies that included associations between dietary fatty acid intake and the risk for AD, dementia, or MCI were included. Fourteen studies were included, comprising 54 177 participants: 1696 patients with AD, 1118 patients with dementia, and 2889 with MCI. The pooled RR showed a significant association only between ω-3 polyunsaturated fatty acid (PUFA) intake and MCI risk (RR, 0.86; 95% CI, 0.75-0.98), with no heterogeneity between studies (I2 = 0%). The intake of total fatty acids, saturated fatty acids (SFAs), cholesterol, monounsaturated fatty acids (MUFAs), PUFAs, ω-3 PUFAs, ω-6 PUFAs, docosahexaenoic acids (DHAs), and eicosapentaenoic acids (EPAs) was not significantly associated with AD risk. The intake of total fatty acids, SFAs, MUFAs, PUFAs, and ω-3 PUFAs was not significantly associated with dementia risk. This meta-analysis provided evidence that ω-3 PUFA intake may be negatively associated with MCI risk. SN - 1873-1244 UR - https://www.unboundmedicine.com/medline/citation/34218119/Dietary_fatty_acids_and_risk_for_Alzheimer's_disease_dementia_and_mild_cognitive_impairment:_A_prospective_cohort_meta_analysis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0899-9007(21)00217-3 DB - PRIME DP - Unbound Medicine ER -