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Presentation of unpaired unconditional stimuli during extinction reduces renewal of conditional fear and slows re-acquisition.
Psychophysiology. 2021 10; 58(10):e13899.P

Abstract

Past research has shown that presenting unconditional stimuli (US) during extinction training, either paired with the conditional stimulus (CS) or explicitly unpaired, can reduce spontaneous recovery and slow the re-acquisition of conditional fear. Whether contextual renewal of conditioned fear as indexed by electrodermal responses and self-report measures of anxiety and CS evaluations is also reduced after presentation of paired or unpaired USs during extinction training is currently unclear. Three groups of participants (Paired, Unpaired, Standard Extinction) completed a sequence of habituation, acquisition, extinction, renewal, and re-acquisition phases. During extinction, five CS-US pairings were presented in group Paired, whereas five US were presented alone in group Unpaired. No US were presented during standard extinction. For all groups, extinction was conducted in a context that was different from that of the other phases. Extinction of differential electrodermal responding was evident in groups Unpaired and Standard, but not in group Paired. Contextual renewal and fast re-acquisition, as indexed by differential electrodermal responding, were evident in group Standard, but not in group Unpaired and differential electrodermal responding persisted in group Paired. After extinction, self-reported anxiety was higher in groups Paired and Unpaired, but differential CS evaluations were evident in group Paired only. The current results suggest that presenting additional unpaired USs during extinction training strengthens extinction and protects against the renewal of differential electrodermal responding.

Authors+Show Affiliations

Curtin School of Population Health, Curtin University, Perth, WA, Australia. School of Psychology and Counselling, Queensland University of Technology, Brisbane, QLD, Australia.School of Applied Psychology, Griffith University, Brisbane, QLD, Australia.Curtin School of Population Health, Curtin University, Perth, WA, Australia.Department of Psychology, UCLA, Los Angeles, CA, USA.School of Applied Psychology, Griffith University, Brisbane, QLD, Australia.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

34231228

Citation

Lipp, Ottmar V., et al. "Presentation of Unpaired Unconditional Stimuli During Extinction Reduces Renewal of Conditional Fear and Slows Re-acquisition." Psychophysiology, vol. 58, no. 10, 2021, pp. e13899.
Lipp OV, Ryan KM, Luck CC, et al. Presentation of unpaired unconditional stimuli during extinction reduces renewal of conditional fear and slows re-acquisition. Psychophysiology. 2021;58(10):e13899.
Lipp, O. V., Ryan, K. M., Luck, C. C., Craske, M. G., & Waters, A. M. (2021). Presentation of unpaired unconditional stimuli during extinction reduces renewal of conditional fear and slows re-acquisition. Psychophysiology, 58(10), e13899. https://doi.org/10.1111/psyp.13899
Lipp OV, et al. Presentation of Unpaired Unconditional Stimuli During Extinction Reduces Renewal of Conditional Fear and Slows Re-acquisition. Psychophysiology. 2021;58(10):e13899. PubMed PMID: 34231228.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Presentation of unpaired unconditional stimuli during extinction reduces renewal of conditional fear and slows re-acquisition. AU - Lipp,Ottmar V, AU - Ryan,Katherine M, AU - Luck,Camilla C, AU - Craske,Michelle G, AU - Waters,Allison M, Y1 - 2021/07/06/ PY - 2021/06/20/revised PY - 2021/04/05/received PY - 2021/06/21/accepted PY - 2021/7/8/pubmed PY - 2022/2/8/medline PY - 2021/7/7/entrez KW - SCR KW - electrodermal responses KW - fear conditioning KW - partially reinforced extinction KW - re-acquisition KW - renewal KW - return of fear KW - unpaired extinction SP - e13899 EP - e13899 JF - Psychophysiology JO - Psychophysiology VL - 58 IS - 10 N2 - Past research has shown that presenting unconditional stimuli (US) during extinction training, either paired with the conditional stimulus (CS) or explicitly unpaired, can reduce spontaneous recovery and slow the re-acquisition of conditional fear. Whether contextual renewal of conditioned fear as indexed by electrodermal responses and self-report measures of anxiety and CS evaluations is also reduced after presentation of paired or unpaired USs during extinction training is currently unclear. Three groups of participants (Paired, Unpaired, Standard Extinction) completed a sequence of habituation, acquisition, extinction, renewal, and re-acquisition phases. During extinction, five CS-US pairings were presented in group Paired, whereas five US were presented alone in group Unpaired. No US were presented during standard extinction. For all groups, extinction was conducted in a context that was different from that of the other phases. Extinction of differential electrodermal responding was evident in groups Unpaired and Standard, but not in group Paired. Contextual renewal and fast re-acquisition, as indexed by differential electrodermal responding, were evident in group Standard, but not in group Unpaired and differential electrodermal responding persisted in group Paired. After extinction, self-reported anxiety was higher in groups Paired and Unpaired, but differential CS evaluations were evident in group Paired only. The current results suggest that presenting additional unpaired USs during extinction training strengthens extinction and protects against the renewal of differential electrodermal responding. SN - 1540-5958 UR - https://www.unboundmedicine.com/medline/citation/34231228/Presentation_of_unpaired_unconditional_stimuli_during_extinction_reduces_renewal_of_conditional_fear_and_slows_re_acquisition_ L2 - https://doi.org/10.1111/psyp.13899 DB - PRIME DP - Unbound Medicine ER -