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Pathognomonic macular ripples are revealed by polarized infrared retinal imaging.
Exp Biol Med (Maywood). 2021 10; 246(20):2202-2206.EB

Abstract

A pathognomonic macular ripple sign has been reported with scanning laser ophthalmoscopy images in patients with foveal hypoplasia, though the optical basis of this sign is presently unknown. Here we present a case series of seven individuals with foveal hypoplasia (based on spectral domain optical coherence tomography). Each patient underwent infrared scanning laser ophthalmoscopy retinal imaging in both eyes, acquired with and without a polarization filter and assessment for a ripple-like effect in the fovea. On imaging, macular ripples were present in all eyes with foveal hypoplasia when using a polarization filter, but not when imaged without the filter. We conclude that the macular ripple sign is an imaging artifact attributable to the unique pattern of phase retardation of the Henle fiber layer in the setting of foveal hypoplasia. By utilizing a polarization filter with retinal photography, this feature can be exploited to promptly identify foveal hypoplasia in settings where OCT is not possible due to nystagmus.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Ansari D
Department of Ophthalmology, University of Illinois at Chicago College of Medicine, Chicago, IL 60612, USA.
Borkar PP
Department of Ophthalmology, University of Illinois at Chicago College of Medicine, Chicago, IL 60612, USA.
Davis PL
Loyola University Medical Center, Maywood, IL 60153, USA.
Collison FT
The Pangere Center for Inherited Retinal Diseases, The Chicago Lighthouse, Chicago, IL 60608, USA. Chicago College of Optometry, Midwestern University, Downers Grove, IL 60515, USA.
Wynne N
Department of Ophthalmology & Visual Sciences, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Zangler N
Brenart Eye Clinic, Yorkville, IL 60560, USA.
Fishman GA
Department of Ophthalmology, University of Illinois at Chicago College of Medicine, Chicago, IL 60612, USA. The Pangere Center for Inherited Retinal Diseases, The Chicago Lighthouse, Chicago, IL 60608, USA.
Carroll J
Department of Ophthalmology & Visual Sciences, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Yao X
Department of Ophthalmology, University of Illinois at Chicago College of Medicine, Chicago, IL 60612, USA. Department of Bioengineering, University of Illinois at Chicago College of Engineering, Chicago, IL 60607, USA.
Grassi MA
Department of Ophthalmology, University of Illinois at Chicago College of Medicine, Chicago, IL 60612, USA. Grassi Retina, Naperville, IL 60564, USA.

MeSH

AdolescentAdultChildFemaleFovea CentralisHumansMaleMiddle AgedOphthalmoscopyTomography, Optical CoherenceVision Disorders

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

34233520

Citation

Ansari, Darius, et al. "Pathognomonic Macular Ripples Are Revealed By Polarized Infrared Retinal Imaging." Experimental Biology and Medicine (Maywood, N.J.), vol. 246, no. 20, 2021, pp. 2202-2206.
Ansari D, Borkar PP, Davis PL, et al. Pathognomonic macular ripples are revealed by polarized infrared retinal imaging. Exp Biol Med (Maywood). 2021;246(20):2202-2206.
Ansari, D., Borkar, P. P., Davis, P. L., Collison, F. T., Wynne, N., Zangler, N., Fishman, G. A., Carroll, J., Yao, X., & Grassi, M. A. (2021). Pathognomonic macular ripples are revealed by polarized infrared retinal imaging. Experimental Biology and Medicine (Maywood, N.J.), 246(20), 2202-2206. https://doi.org/10.1177/15353702211021089
Ansari D, et al. Pathognomonic Macular Ripples Are Revealed By Polarized Infrared Retinal Imaging. Exp Biol Med (Maywood). 2021;246(20):2202-2206. PubMed PMID: 34233520.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pathognomonic macular ripples are revealed by polarized infrared retinal imaging. AU - Ansari,Darius, AU - Borkar,Poulami P, AU - Davis,Patricia L, AU - Collison,Frederick T, AU - Wynne,Niamh, AU - Zangler,Nicole, AU - Fishman,Gerald A, AU - Carroll,Joseph, AU - Yao,Xincheng, AU - Grassi,Michael A, Y1 - 2021/07/07/ PY - 2022/10/01/pmc-release PY - 2021/7/9/pubmed PY - 2021/12/15/medline PY - 2021/7/8/entrez KW - Polarization KW - fovea plana KW - foveal hypoplasia KW - scanning laser ophthalmoscopy SP - 2202 EP - 2206 JF - Experimental biology and medicine (Maywood, N.J.) JO - Exp Biol Med (Maywood) VL - 246 IS - 20 N2 - A pathognomonic macular ripple sign has been reported with scanning laser ophthalmoscopy images in patients with foveal hypoplasia, though the optical basis of this sign is presently unknown. Here we present a case series of seven individuals with foveal hypoplasia (based on spectral domain optical coherence tomography). Each patient underwent infrared scanning laser ophthalmoscopy retinal imaging in both eyes, acquired with and without a polarization filter and assessment for a ripple-like effect in the fovea. On imaging, macular ripples were present in all eyes with foveal hypoplasia when using a polarization filter, but not when imaged without the filter. We conclude that the macular ripple sign is an imaging artifact attributable to the unique pattern of phase retardation of the Henle fiber layer in the setting of foveal hypoplasia. By utilizing a polarization filter with retinal photography, this feature can be exploited to promptly identify foveal hypoplasia in settings where OCT is not possible due to nystagmus. SN - 1535-3699 UR - https://www.unboundmedicine.com/medline/citation/34233520/Pathognomonic_macular_ripples_are_revealed_by_polarized_infrared_retinal_imaging_ DB - PRIME DP - Unbound Medicine ER -