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The variants question: What is the problem?
J Med Virol. 2021 Dec; 93(12):6479-6485.JM

Abstract

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) originated in Wuhan, China in early December 2019 has rapidly widespread worldwide. Over the course of the pandemic, due to the advance of whole-genome sequencing technologies, an unprecedented number of genomes have been generated, providing both invaluable insights into the ongoing evolution and epidemiology of the virus and allowing the identification of hundreds of circulating genetic variants during the pandemic. In recent months variants of SARS-CoV-2 that have an increased number of mutations on the Spike protein have brought concern all over the world. These have been called "variants of concerns" (VOCs), and/or "variants of interests" (VOIs) as it has been suggested that their genome mutations might impact transmission, immune control, and virulence. Tracking the spread of emerging SARS-CoV-2 variants is crucial to inform public health efforts and control the ongoing pandemic. In this review, a concise characterization of the SARS-CoV-2 mutational patterns of the main VOCs and VOIs circulating and cocirculating worldwide has been presented to determine the magnitude of the SARS-CoV-2 threat to better understand the virus genetic diversity and its potential impact on vaccination strategy.

Authors+Show Affiliations

Department of Biochemistry and Molecular Biology, Institute of Human Virology and Global Virus Network Center, University of Maryland School of Medicine, Baltimore, Maryland, USA.Laboratório de Flavivírus, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil. Laboratório de Genética Celular e Molecular, ICB, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.Department of Biochemistry and Molecular Biology, Institute of Human Virology and Global Virus Network Center, University of Maryland School of Medicine, Baltimore, Maryland, USA.Area Comunicazione e Brand Management, University Campus Bio-Medico of Rome, Rome, Italy.Department of Diagnostic and Therapeutic Medicine, University Campus Bio-Medico of Rome, Rome, Italy.Department of Gastrointestinal Diseases, Campus Bio-Medico University, Rome, Italy.Unit of Clinical Laboratory Science, University Campus Bio-Medico of Rome, Rome, Italy.Medical Statistic and Molecular Epidemiology Unit, University of Biomedical Campus, Rome, Italy.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

34255352

Citation

Zella, Davide, et al. "The Variants Question: what Is the Problem?" Journal of Medical Virology, vol. 93, no. 12, 2021, pp. 6479-6485.
Zella D, Giovanetti M, Benedetti F, et al. The variants question: What is the problem? J Med Virol. 2021;93(12):6479-6485.
Zella, D., Giovanetti, M., Benedetti, F., Unali, F., Spoto, S., Guarino, M., Angeletti, S., & Ciccozzi, M. (2021). The variants question: What is the problem? Journal of Medical Virology, 93(12), 6479-6485. https://doi.org/10.1002/jmv.27196
Zella D, et al. The Variants Question: what Is the Problem. J Med Virol. 2021;93(12):6479-6485. PubMed PMID: 34255352.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The variants question: What is the problem? AU - Zella,Davide, AU - Giovanetti,Marta, AU - Benedetti,Francesca, AU - Unali,Francesco, AU - Spoto,Silvia, AU - Guarino,Michele, AU - Angeletti,Silvia, AU - Ciccozzi,Massimo, Y1 - 2021/07/28/ PY - 2021/07/03/revised PY - 2021/06/21/received PY - 2021/07/08/accepted PY - 2021/7/14/pubmed PY - 2021/10/28/medline PY - 2021/7/13/entrez KW - SARS-CoV-2 KW - VOCs KW - VOIs KW - intervention strategies KW - pandemic KW - vaccine SP - 6479 EP - 6485 JF - Journal of medical virology JO - J Med Virol VL - 93 IS - 12 N2 - The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) originated in Wuhan, China in early December 2019 has rapidly widespread worldwide. Over the course of the pandemic, due to the advance of whole-genome sequencing technologies, an unprecedented number of genomes have been generated, providing both invaluable insights into the ongoing evolution and epidemiology of the virus and allowing the identification of hundreds of circulating genetic variants during the pandemic. In recent months variants of SARS-CoV-2 that have an increased number of mutations on the Spike protein have brought concern all over the world. These have been called "variants of concerns" (VOCs), and/or "variants of interests" (VOIs) as it has been suggested that their genome mutations might impact transmission, immune control, and virulence. Tracking the spread of emerging SARS-CoV-2 variants is crucial to inform public health efforts and control the ongoing pandemic. In this review, a concise characterization of the SARS-CoV-2 mutational patterns of the main VOCs and VOIs circulating and cocirculating worldwide has been presented to determine the magnitude of the SARS-CoV-2 threat to better understand the virus genetic diversity and its potential impact on vaccination strategy. SN - 1096-9071 UR - https://www.unboundmedicine.com/medline/citation/34255352/The_variants_question:_What_is_the_problem L2 - https://doi.org/10.1002/jmv.27196 DB - PRIME DP - Unbound Medicine ER -