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Placental response to maternal SARS-CoV-2 infection.
Sci Rep. 2021 07 13; 11(1):14390.SR

Abstract

The coronavirus disease 2019 (COVID-19) pandemic affected people at all ages. Whereas pregnant women seemed to have a worse course of disease than age-matched non-pregnant women, the risk of feto-placental infection is low. Using a cohort of 66 COVID-19-positive women in late pregnancy, we correlated clinical parameters with disease severity, placental histopathology, and the expression of viral entry and Interferon-induced transmembrane (IFITM) antiviral transcripts. All newborns were negative for SARS-CoV-2. None of the demographic parameters or placental histopathological characteristics were associated with disease severity. The fetal-maternal transfer ratio for IgG against the N or S viral proteins was commonly less than one, as recently reported. We found that the expression level of placental ACE2, but not TMPRSS2 or Furin, was higher in women with severe COVID-19. Placental expression of IFITM1 and IFITM3, which have been implicated in antiviral response, was higher in participants with severe disease. We also showed that IFITM3 protein expression, which localized to early and late endosomes, was enhanced in severe COVID-19. Our data suggest an association between disease severity and placental SARS-CoV-2 processing and antiviral pathways, implying a role for these proteins in placental response to SARS-CoV-2.

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Authors+Show Affiliations

Mourad M
Department of Obstetrics, Gynecology and Reproductive Science, College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA.
Jacob T
Department of Obstetrics, Gynecology and Reproductive Science, College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA.
Sadovsky E
Magee-Womens Research Institute, Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh, 204 Craft Avenue, Pittsburgh, PA, 15213, USA.
Bejerano S
Department of Obstetrics, Gynecology and Reproductive Science, College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA.
Simone GS
Department of Obstetrics, Gynecology and Reproductive Science, College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA.
Bagalkot TR
Department of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Zucker J
Department of Medicine, College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA.
Yin MT
Department of Medicine, College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA.
Chang JY
Department of Medicine, College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA.
Liu L
Department of Medicine, College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA.
Debelenko L
Department of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA.
Shawber CJ
Department of Obstetrics, Gynecology and Reproductive Science, College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA. Department of Surgery, College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA.
Firestein M
Department of Psychiatry, College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA.
Ouyang Y
Magee-Womens Research Institute, Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh, 204 Craft Avenue, Pittsburgh, PA, 15213, USA.
Gyamfi-Bannerman C
Department of Obstetrics, Gynecology and Reproductive Science, College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA.
Penn A
Department of Pediatrics, College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA.
Sorkin A
Department of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Wapner R
Department of Obstetrics, Gynecology and Reproductive Science, College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA.
Sadovsky Y
Magee-Womens Research Institute, Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh, 204 Craft Avenue, Pittsburgh, PA, 15213, USA. ysadovsky@mwri.magee.edu. Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. ysadovsky@mwri.magee.edu.

MeSH

AdultAngiotensin-Converting Enzyme 2COVID-19FemaleFurinHumansImmunoglobulin GInfectious Disease Transmission, VerticalMaleNucleocapsid ProteinsPlacentaPregnancyPregnancy Complications, InfectiousSARS-CoV-2Serine EndopeptidasesSpike Glycoprotein, CoronavirusYoung Adult

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

34257394

Citation

Mourad, Mirella, et al. "Placental Response to Maternal SARS-CoV-2 Infection." Scientific Reports, vol. 11, no. 1, 2021, p. 14390.
Mourad M, Jacob T, Sadovsky E, et al. Placental response to maternal SARS-CoV-2 infection. Sci Rep. 2021;11(1):14390.
Mourad, M., Jacob, T., Sadovsky, E., Bejerano, S., Simone, G. S., Bagalkot, T. R., Zucker, J., Yin, M. T., Chang, J. Y., Liu, L., Debelenko, L., Shawber, C. J., Firestein, M., Ouyang, Y., Gyamfi-Bannerman, C., Penn, A., Sorkin, A., Wapner, R., & Sadovsky, Y. (2021). Placental response to maternal SARS-CoV-2 infection. Scientific Reports, 11(1), 14390. https://doi.org/10.1038/s41598-021-93931-0
Mourad M, et al. Placental Response to Maternal SARS-CoV-2 Infection. Sci Rep. 2021 07 13;11(1):14390. PubMed PMID: 34257394.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Placental response to maternal SARS-CoV-2 infection. AU - Mourad,Mirella, AU - Jacob,Taylor, AU - Sadovsky,Elena, AU - Bejerano,Shai, AU - Simone,Glicella Salazar-De, AU - Bagalkot,Tarique Rajasaheb, AU - Zucker,Jason, AU - Yin,Michael T, AU - Chang,Jennifer Y, AU - Liu,Lihong, AU - Debelenko,Larisa, AU - Shawber,Carrie J, AU - Firestein,Morgan, AU - Ouyang,Yingshi, AU - Gyamfi-Bannerman,Cynthia, AU - Penn,Anna, AU - Sorkin,Alexander, AU - Wapner,Ronald, AU - Sadovsky,Yoel, Y1 - 2021/07/13/ PY - 2021/04/12/received PY - 2021/06/29/accepted PY - 2021/7/14/entrez PY - 2021/7/15/pubmed PY - 2021/7/27/medline SP - 14390 EP - 14390 JF - Scientific reports JO - Sci Rep VL - 11 IS - 1 N2 - The coronavirus disease 2019 (COVID-19) pandemic affected people at all ages. Whereas pregnant women seemed to have a worse course of disease than age-matched non-pregnant women, the risk of feto-placental infection is low. Using a cohort of 66 COVID-19-positive women in late pregnancy, we correlated clinical parameters with disease severity, placental histopathology, and the expression of viral entry and Interferon-induced transmembrane (IFITM) antiviral transcripts. All newborns were negative for SARS-CoV-2. None of the demographic parameters or placental histopathological characteristics were associated with disease severity. The fetal-maternal transfer ratio for IgG against the N or S viral proteins was commonly less than one, as recently reported. We found that the expression level of placental ACE2, but not TMPRSS2 or Furin, was higher in women with severe COVID-19. Placental expression of IFITM1 and IFITM3, which have been implicated in antiviral response, was higher in participants with severe disease. We also showed that IFITM3 protein expression, which localized to early and late endosomes, was enhanced in severe COVID-19. Our data suggest an association between disease severity and placental SARS-CoV-2 processing and antiviral pathways, implying a role for these proteins in placental response to SARS-CoV-2. SN - 2045-2322 UR - https://www.unboundmedicine.com/medline/citation/34257394/Placental_response_to_maternal_SARS_CoV_2_infection_ DB - PRIME DP - Unbound Medicine ER -