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Transplant of SARS-CoV-2-infected Living Donor Liver: Case Report.
Transplant Direct. 2021 Aug; 7(8):e721.TD

Abstract

Given the high community prevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), transplant programs will encounter SARS-CoV-2 infections in living donors or recipients in the perioperative period. There is limited data on SARS-CoV-2 viremia and organotropism beyond the respiratory tract to inform the risk of transplant transmission of SARS-CoV-2. We report a case of a living donor liver transplant recipient who received a right lobe graft from a living donor with symptomatic PCR-confirmed SARS-CoV-2 infection 3 d following donation. The donor was successfully treated with remdesivir, dexamethasone, and coronavirus disease 2019 (COVID-19) convalescent plasma. No viral transmission was identified, and both donor and recipient had excellent postoperative outcomes.

Authors+Show Affiliations

Division of Transplant Surgery, Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD.Division of Transplant Surgery, Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD.Division of Infectious Diseases, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD.Division of Infectious Diseases, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD.Division of Infectious Diseases, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD.Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD.Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD.Division of Gastroenterology and Hepatology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD.Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD.Division of Transplant Surgery, Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD. Department of Epidemiology, Johns Hopkins School of Public Health, Baltimore, MD.Division of Transplant Surgery, Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD.Division of Transplant Surgery, Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD.Division of Transplant Surgery, Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD. Department of Epidemiology, Johns Hopkins School of Public Health, Baltimore, MD.Division of Transplant Surgery, Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD.Division of Transplant Surgery, Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

34258388

Citation

Nguyen, Michelle C., et al. "Transplant of SARS-CoV-2-infected Living Donor Liver: Case Report." Transplantation Direct, vol. 7, no. 8, 2021, pp. e721.
Nguyen MC, Lee EJ, Avery RK, et al. Transplant of SARS-CoV-2-infected Living Donor Liver: Case Report. Transplant Direct. 2021;7(8):e721.
Nguyen, M. C., Lee, E. J., Avery, R. K., Dioverti-Prono, M. V., Shoham, S., Tobian, A. A. R., Bloch, E. M., Gurakar, A., Rizkalla, N. A., Cameron, A. M., King, E. A., Ottmann, S., Garonzik-Wang, J. M., Wesson, R. N., & Philosophe, B. (2021). Transplant of SARS-CoV-2-infected Living Donor Liver: Case Report. Transplantation Direct, 7(8), e721. https://doi.org/10.1097/TXD.0000000000001178
Nguyen MC, et al. Transplant of SARS-CoV-2-infected Living Donor Liver: Case Report. Transplant Direct. 2021;7(8):e721. PubMed PMID: 34258388.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Transplant of SARS-CoV-2-infected Living Donor Liver: Case Report. AU - Nguyen,Michelle C, AU - Lee,Eliza J, AU - Avery,Robin K, AU - Dioverti-Prono,M Veronica, AU - Shoham,Shmuel, AU - Tobian,Aaron A R, AU - Bloch,Evan M, AU - Gurakar,Ahmet, AU - Rizkalla,Nicole A, AU - Cameron,Andrew M, AU - King,Elizabeth A, AU - Ottmann,Shane, AU - Garonzik-Wang,Jacqueline M, AU - Wesson,Russel N, AU - Philosophe,Benjamin, Y1 - 2021/07/08/ PY - 2021/02/22/received PY - 2021/04/02/revised PY - 2021/04/26/accepted PY - 2021/7/14/entrez PY - 2021/7/15/pubmed PY - 2021/7/15/medline SP - e721 EP - e721 JF - Transplantation direct JO - Transplant Direct VL - 7 IS - 8 N2 - Given the high community prevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), transplant programs will encounter SARS-CoV-2 infections in living donors or recipients in the perioperative period. There is limited data on SARS-CoV-2 viremia and organotropism beyond the respiratory tract to inform the risk of transplant transmission of SARS-CoV-2. We report a case of a living donor liver transplant recipient who received a right lobe graft from a living donor with symptomatic PCR-confirmed SARS-CoV-2 infection 3 d following donation. The donor was successfully treated with remdesivir, dexamethasone, and coronavirus disease 2019 (COVID-19) convalescent plasma. No viral transmission was identified, and both donor and recipient had excellent postoperative outcomes. SN - 2373-8731 UR - https://www.unboundmedicine.com/medline/citation/34258388/Transplant_of_SARS-CoV-2-infected_Living_Donor_Liver:_Case_Report. L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/34258388/ DB - PRIME DP - Unbound Medicine ER -
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