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[Effect of Tongdu Tiaoshen acupuncture on serum GABA and CORT levels in patients with chronic insomnia].
Zhongguo Zhen Jiu. 2021 Jul 12; 41(7):721-4.ZZ

Abstract

OBJECTIVE

To observe the clinical effect of Tongdu Tiaoshen acupuncture on chronic insomnia, and explore its possible mechanism.

METHODS

A total of 60 patients with chronic insomnia were randomly divided into an observation group (30 cases) and a control group (30 cases, 1 case dropped off). The observation group was treated with Tongdu Tiaoshen acupuncture at Baihui (GV 20), Yintang (GV 29), Shenting (GV 24), etc. once every other day, 3 times a week. The control group was treated with estazolam tablets (1 mg) orally before going to bed every night. The treatments of both groups were required 4 weeks. The Pittsburgh sleep quality index (PSQI) scores, serum gamma-aminobutyric acid (GABA) and cortisol (CORT) levels were observed before and after treatment in the two groups, and the clinical effect was compared.

RESULTS

After treatment, the sleep quality, day dysfunction scores of PSQI in the observation group and the falling asleep time, sleep time, sleep efficiency, sleep disturbance scores and total scores of PSQI in the two groups were lower than before treatment (P<0.01, P<0.05). After treatment, the daytime dysfunction score of PSQI in the observation group was lower than that in the control group (P<0.05). After treatment, the serum GABA levels in the two groups were higher than before treatment (P<0.05), and the serum CORT levels were lower than before treatment (P<0.01). The total effective rate was 90% (27/30) in the observation group and 93.1% (27/29) in the control group, the difference was not statistically significant (P>0.05).

CONCLUSION

Tongdu Tiaoshen acupuncture has the same effect as western medication estazolam tablets in the treatment of patients with chronic insomnia, and has little effect on daytime dysfunction. The mechanism may be related to the increase of serum GABA level and the inhibition of the hyperactivation of hypothalamus-pituitary-adrenal (HPA) axis.

Authors+Show Affiliations

Department of Acupuncture-Moxibustion and Rehabilitation, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, Jiangsu Province, China.Department of Acupuncture-Moxibustion and Rehabilitation, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, Jiangsu Province, China.Department of Acupuncture-Moxibustion and Rehabilitation, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, Jiangsu Province, China.Department of Acupuncture-Moxibustion and Rehabilitation, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, Jiangsu Province, China.Department of Acupuncture-Moxibustion and Rehabilitation, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, Jiangsu Province, China.Department of Acupuncture-Moxibustion and Rehabilitation, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, Jiangsu Province, China.Department of Acupuncture-Moxibustion and Rehabilitation, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, Jiangsu Province, China.Department of Acupuncture-Moxibustion and Rehabilitation, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, Jiangsu Province, China.Department of Acupuncture-Moxibustion and Rehabilitation, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, Jiangsu Province, China.

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

chi

PubMed ID

34259401

Citation

Wu, Wen-Zhong, et al. "[Effect of Tongdu Tiaoshen Acupuncture On Serum GABA and CORT Levels in Patients With Chronic Insomnia]." Zhongguo Zhen Jiu = Chinese Acupuncture & Moxibustion, vol. 41, no. 7, 2021, pp. 721-4.
Wu WZ, Zheng SY, Liu CY, et al. [Effect of Tongdu Tiaoshen acupuncture on serum GABA and CORT levels in patients with chronic insomnia]. Zhongguo Zhen Jiu. 2021;41(7):721-4.
Wu, W. Z., Zheng, S. Y., Liu, C. Y., Qin, S., Wang, X. Q., Hu, J. L., Wan, Q. Y., Zhao, Y. N., & Xi, H. Q. (2021). [Effect of Tongdu Tiaoshen acupuncture on serum GABA and CORT levels in patients with chronic insomnia]. Zhongguo Zhen Jiu = Chinese Acupuncture & Moxibustion, 41(7), 721-4. https://doi.org/10.13703/j.0255-2930.20200704-k0001
Wu WZ, et al. [Effect of Tongdu Tiaoshen Acupuncture On Serum GABA and CORT Levels in Patients With Chronic Insomnia]. Zhongguo Zhen Jiu. 2021 Jul 12;41(7):721-4. PubMed PMID: 34259401.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Effect of Tongdu Tiaoshen acupuncture on serum GABA and CORT levels in patients with chronic insomnia]. AU - Wu,Wen-Zhong, AU - Zheng,Shi-Yu, AU - Liu,Cheng-Yong, AU - Qin,Shan, AU - Wang,Xiao-Qiu, AU - Hu,Jin-Li, AU - Wan,Qing-Yun, AU - Zhao,Ya-Nan, AU - Xi,Han-Qing, PY - 2021/7/14/entrez PY - 2021/7/15/pubmed PY - 2021/7/16/medline KW - acupuncture KW - chronic insomnia KW - cortisol (CORT) KW - daytime dysfunction KW - gamma-aminobutyric acid (GABA) KW - randomized controlled trial (RCT) SP - 721 EP - 4 JF - Zhongguo zhen jiu = Chinese acupuncture & moxibustion JO - Zhongguo Zhen Jiu VL - 41 IS - 7 N2 - OBJECTIVE: To observe the clinical effect of Tongdu Tiaoshen acupuncture on chronic insomnia, and explore its possible mechanism. METHODS: A total of 60 patients with chronic insomnia were randomly divided into an observation group (30 cases) and a control group (30 cases, 1 case dropped off). The observation group was treated with Tongdu Tiaoshen acupuncture at Baihui (GV 20), Yintang (GV 29), Shenting (GV 24), etc. once every other day, 3 times a week. The control group was treated with estazolam tablets (1 mg) orally before going to bed every night. The treatments of both groups were required 4 weeks. The Pittsburgh sleep quality index (PSQI) scores, serum gamma-aminobutyric acid (GABA) and cortisol (CORT) levels were observed before and after treatment in the two groups, and the clinical effect was compared. RESULTS: After treatment, the sleep quality, day dysfunction scores of PSQI in the observation group and the falling asleep time, sleep time, sleep efficiency, sleep disturbance scores and total scores of PSQI in the two groups were lower than before treatment (P<0.01, P<0.05). After treatment, the daytime dysfunction score of PSQI in the observation group was lower than that in the control group (P<0.05). After treatment, the serum GABA levels in the two groups were higher than before treatment (P<0.05), and the serum CORT levels were lower than before treatment (P<0.01). The total effective rate was 90% (27/30) in the observation group and 93.1% (27/29) in the control group, the difference was not statistically significant (P>0.05). CONCLUSION: Tongdu Tiaoshen acupuncture has the same effect as western medication estazolam tablets in the treatment of patients with chronic insomnia, and has little effect on daytime dysfunction. The mechanism may be related to the increase of serum GABA level and the inhibition of the hyperactivation of hypothalamus-pituitary-adrenal (HPA) axis. SN - 0255-2930 UR - https://www.unboundmedicine.com/medline/citation/34259401/[Effect_of_Tongdu_Tiaoshen_acupuncture_on_serum_GABA_and_CORT_levels_in_patients_with_chronic_insomnia]_ L2 - https://medlineplus.gov/insomnia.html DB - PRIME DP - Unbound Medicine ER -