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Secondary Syphilis in a 12-Year-Old Girl Misdiagnosed as Pityriasis lichenoides et varioliformis acuta: A Case Report.
Clin Cosmet Investig Dermatol. 2021; 14:815-820.CC

Abstract

Syphilis is a complex, systemic infectious disease caused by Treponema pallidum subspecies pallidum. Herein, we report a rare case of secondary syphilis with probable neurosyphilis that was misdiagnosed as pityriasis lichenoides et varioliformis acuta (PLEVA) in a 12-year-old human immunodeficiency virus (HIV) negative patient. A female patient presented to our hospital with a four-month history of relapsed systemic rash, accompanied by hair loss, arthralgia and fatigue. Based on physical examination and skin biopsy, she was initially diagnosed as PLEVA and treated both locally and systemically but failed to present a dermatologic improvement. The diagnosis of secondary syphilis with probable neurosyphilis was made based on serologic and cerebrospinal fluid tests. After neurosyphilis therapy, the clinical manifestations of the patient were significantly improved. Physicians should be alert for the possibility of syphilis when encountering cases with unusual clinical manifestations.

Authors+Show Affiliations

Department of Dermatology and Venereology, The First Affiliated Hospital, Army Medical University, Chongqing, People's Republic of China.Department of Dermatology, Distinct HealthCare, Chongqing, People's Republic of China.Department of Dermatology and Venereology, The First Affiliated Hospital, Army Medical University, Chongqing, People's Republic of China.Department of Dermatology and Venereology, The First Affiliated Hospital, Army Medical University, Chongqing, People's Republic of China.Department of Dermatology and Venereology, The First Affiliated Hospital, Army Medical University, Chongqing, People's Republic of China.Department of Dermatology and Venereology, The First Affiliated Hospital, Army Medical University, Chongqing, People's Republic of China.Department of Dermatology and Venereology, The First Affiliated Hospital, Army Medical University, Chongqing, People's Republic of China.

Pub Type(s)

Case Reports

Language

eng

PubMed ID

34262318

Citation

Zhang, Min, et al. "Secondary Syphilis in a 12-Year-Old Girl Misdiagnosed as Pityriasis Lichenoides Et Varioliformis Acuta: a Case Report." Clinical, Cosmetic and Investigational Dermatology, vol. 14, 2021, pp. 815-820.
Zhang M, Yu J, Huang H, et al. Secondary Syphilis in a 12-Year-Old Girl Misdiagnosed as Pityriasis lichenoides et varioliformis acuta: A Case Report. Clin Cosmet Investig Dermatol. 2021;14:815-820.
Zhang, M., Yu, J., Huang, H., Zhou, C., Zhai, Z., You, Y., & Song, Z. (2021). Secondary Syphilis in a 12-Year-Old Girl Misdiagnosed as Pityriasis lichenoides et varioliformis acuta: A Case Report. Clinical, Cosmetic and Investigational Dermatology, 14, 815-820. https://doi.org/10.2147/CCID.S315235
Zhang M, et al. Secondary Syphilis in a 12-Year-Old Girl Misdiagnosed as Pityriasis Lichenoides Et Varioliformis Acuta: a Case Report. Clin Cosmet Investig Dermatol. 2021;14:815-820. PubMed PMID: 34262318.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Secondary Syphilis in a 12-Year-Old Girl Misdiagnosed as Pityriasis lichenoides et varioliformis acuta: A Case Report. AU - Zhang,Min, AU - Yu,Jia, AU - Huang,Hui, AU - Zhou,Cunjian, AU - Zhai,Zhifang, AU - You,Yi, AU - Song,Zhiqiang, Y1 - 2021/07/06/ PY - 2021/04/13/received PY - 2021/06/11/accepted PY - 2021/7/15/entrez PY - 2021/7/16/pubmed PY - 2021/7/16/medline KW - neurosyphilis KW - pityriasis lichenoides et varioliformis acuta KW - syphilis SP - 815 EP - 820 JF - Clinical, cosmetic and investigational dermatology JO - Clin Cosmet Investig Dermatol VL - 14 N2 - Syphilis is a complex, systemic infectious disease caused by Treponema pallidum subspecies pallidum. Herein, we report a rare case of secondary syphilis with probable neurosyphilis that was misdiagnosed as pityriasis lichenoides et varioliformis acuta (PLEVA) in a 12-year-old human immunodeficiency virus (HIV) negative patient. A female patient presented to our hospital with a four-month history of relapsed systemic rash, accompanied by hair loss, arthralgia and fatigue. Based on physical examination and skin biopsy, she was initially diagnosed as PLEVA and treated both locally and systemically but failed to present a dermatologic improvement. The diagnosis of secondary syphilis with probable neurosyphilis was made based on serologic and cerebrospinal fluid tests. After neurosyphilis therapy, the clinical manifestations of the patient were significantly improved. Physicians should be alert for the possibility of syphilis when encountering cases with unusual clinical manifestations. SN - 1178-7015 UR - https://www.unboundmedicine.com/medline/citation/34262318/Secondary_Syphilis_in_a_12_Year_Old_Girl_Misdiagnosed_as_Pityriasis_lichenoides_et_varioliformis_acuta:_A_Case_Report_ L2 - https://dx.doi.org/10.2147/CCID.S315235 DB - PRIME DP - Unbound Medicine ER -
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