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Transmission event of SARS-CoV-2 Delta variant reveals multiple vaccine breakthrough infections.
medRxiv. 2021 Jul 12M

Abstract

Importance

Vaccine breakthrough by an emergent SARS-CoV-2 variant poses a great risk to global public health.

Objective

To determine the SARS-CoV-2 variant responsible for 6 cases of vaccine breakthrough.

Design

Nasopharyngeal swabs from suspected vaccine breakthrough cases were tested for SARS-CoV-2 by qPCR for Wuhan-Hu1 and Alpha variant. Positive samples were then sequenced by Swift Normalase Amplicon Panels to determine the causal variant.

Setting

Transmission event occurred at events surrounding a wedding outside of Houston, TX. Two patients from India, likely transmitted the Delta variant to other guests.

Participants

Following a positive SARS-CoV-2 qPCR test at a third-party site, six fully vaccinated patients were investigated. Three males and three females ranged from 53 to 69 years old. One patient suffered from diabetes while three others were classified as overweight. No significant other comorbidities were identified. None of the patients had a history of failed vaccination.

Key Points

Question: Which SARS-CoV-2 variant is responsible for 6 cases of vaccine breakthrough, one interventional monoclonal antibody treatment, and one death?Findings: Viral sequencing revealed 6 vaccinated patients were infected with the Delta SARS-CoV-2 variant. With no histories of vaccine breakthrough, this suggests Delta variant may possess immune evasion in patients that received the Pfizer BNT162b2, Moderna mRNA-1273, and Covaxin BBV152.Meaning: Delta variant may pose the highest risk out of any currently circulating SARS-CoV-2 variants, with increased transmissibility over Alpha variant and possible vaccine breakthrough.

Authors+Show Affiliations

Alkek Center for Metagenomics and Microbiome Research, Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, USA.Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA. Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA.Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA. Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA.Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA. Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA.Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA. Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA.Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA. Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA.Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA. Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA.Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA. Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA.Department of Medicine, Baylor College of Medicine, Houston, TX, USA.Department of Medicine, Baylor College of Medicine, Houston, TX, USA.Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA. Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA.Alkek Center for Metagenomics and Microbiome Research, Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, USA.Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA. Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA.Alkek Center for Metagenomics and Microbiome Research, Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, USA.

Pub Type(s)

Preprint

Language

eng

PubMed ID

34268529

Citation

Farinholt, Timothy, et al. "Transmission Event of SARS-CoV-2 Delta Variant Reveals Multiple Vaccine Breakthrough Infections." MedRxiv : the Preprint Server for Health Sciences, 2021.
Farinholt T, Doddapaneni H, Qin X, et al. Transmission event of SARS-CoV-2 Delta variant reveals multiple vaccine breakthrough infections. medRxiv. 2021.
Farinholt, T., Doddapaneni, H., Qin, X., Menon, V., Meng, Q., Metcalf, G., Chao, H., Gingras, M. C., Farinholt, P., Agrawal, C., Muzny, D. M., Piedra, P. A., Gibbs, R. A., & Petrosino, J. (2021). Transmission event of SARS-CoV-2 Delta variant reveals multiple vaccine breakthrough infections. MedRxiv : the Preprint Server for Health Sciences. https://doi.org/10.1101/2021.06.28.21258780
Farinholt T, et al. Transmission Event of SARS-CoV-2 Delta Variant Reveals Multiple Vaccine Breakthrough Infections. medRxiv. 2021 Jul 12; PubMed PMID: 34268529.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Transmission event of SARS-CoV-2 Delta variant reveals multiple vaccine breakthrough infections. AU - Farinholt,Timothy, AU - Doddapaneni,Harsha, AU - Qin,Xiang, AU - Menon,Vipin, AU - Meng,Qingchang, AU - Metcalf,Ginger, AU - Chao,Hsu, AU - Gingras,Marie-Claude, AU - Farinholt,Paige, AU - Agrawal,Charu, AU - Muzny,Donna M, AU - Piedra,Pedro A, AU - Gibbs,Richard A, AU - Petrosino,Joseph, Y1 - 2021/07/12/ PY - 2021/7/16/entrez PY - 2021/7/17/pubmed PY - 2021/7/17/medline JF - medRxiv : the preprint server for health sciences JO - medRxiv N2 - Importance: Vaccine breakthrough by an emergent SARS-CoV-2 variant poses a great risk to global public health. Objective: To determine the SARS-CoV-2 variant responsible for 6 cases of vaccine breakthrough. Design: Nasopharyngeal swabs from suspected vaccine breakthrough cases were tested for SARS-CoV-2 by qPCR for Wuhan-Hu1 and Alpha variant. Positive samples were then sequenced by Swift Normalase Amplicon Panels to determine the causal variant. Setting: Transmission event occurred at events surrounding a wedding outside of Houston, TX. Two patients from India, likely transmitted the Delta variant to other guests. Participants: Following a positive SARS-CoV-2 qPCR test at a third-party site, six fully vaccinated patients were investigated. Three males and three females ranged from 53 to 69 years old. One patient suffered from diabetes while three others were classified as overweight. No significant other comorbidities were identified. None of the patients had a history of failed vaccination. Key Points: Question: Which SARS-CoV-2 variant is responsible for 6 cases of vaccine breakthrough, one interventional monoclonal antibody treatment, and one death?Findings: Viral sequencing revealed 6 vaccinated patients were infected with the Delta SARS-CoV-2 variant. With no histories of vaccine breakthrough, this suggests Delta variant may possess immune evasion in patients that received the Pfizer BNT162b2, Moderna mRNA-1273, and Covaxin BBV152.Meaning: Delta variant may pose the highest risk out of any currently circulating SARS-CoV-2 variants, with increased transmissibility over Alpha variant and possible vaccine breakthrough. UR - https://www.unboundmedicine.com/medline/citation/34268529/Transmission_event_of_SARS_CoV_2_Delta_variant_reveals_multiple_vaccine_breakthrough_infections_ L2 - https://doi.org/10.1101/2021.06.28.21258780 DB - PRIME DP - Unbound Medicine ER -
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