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Neuroimaging Findings in Patients with COVID-19: A Systematic Review and Meta-Analysis.
Korean J Radiol. 2021 Jul 01 [Online ahead of print]KJ

Abstract

OBJECTIVE

Central nervous system involvement in coronavirus disease 2019 (COVID-19) has been increasingly reported. We performed a systematic review and meta-analysis to evaluate the incidence of radiologically demonstrated neurologic complications and detailed neuroimaging findings associated with COVID-19.

MATERIALS AND METHODS

A systematic literature search of MEDLINE/PubMed and EMBASE databases was performed up to September 17, 2020, and studies evaluating neuroimaging findings of COVID-19 using brain CT or MRI were included. Several cohort-based outcomes, including the proportion of patients with abnormal neuroimaging findings related to COVID-19 were evaluated. The proportion of patients showing specific neuroimaging findings was also assessed. Subgroup analyses were also conducted focusing on critically ill COVID-19 patients and results from studies that used MRI as the only imaging modality.

RESULTS

A total of 1394 COVID-19 patients who underwent neuroimaging from 17 studies were included; among them, 3.4% of the patients demonstrated COVID-19-related neuroimaging findings. Olfactory bulb abnormalities were the most commonly observed (23.1%). The predominant cerebral neuroimaging finding was white matter abnormality (17.6%), followed by acute/subacute ischemic infarction (16.0%), and encephalopathy (13.0%). Significantly more critically ill patients had COVID-19-related neuroimaging findings than other patients (9.1% vs. 1.6%; p = 0.029). The type of imaging modality used did not significantly affect the proportion of COVID-19-related neuroimaging findings.

CONCLUSION

Abnormal neuroimaging findings were occasionally observed in COVID-19 patients. Olfactory bulb abnormalities were the most commonly observed finding. Critically ill patients showed abnormal neuroimaging findings more frequently than the other patient groups. White matter abnormalities, ischemic infarctions, and encephalopathies were the common cerebral neuroimaging findings.

Authors+Show Affiliations

Department of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.Department of Radiology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea.Department of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea. chonghyunsuh@amc.seoul.kr.Department of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.Department of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.Department of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.Department of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.Department of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.Department of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.Department of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.Department of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.Department of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

34269530

Citation

Kim, Pyeong Hwa, et al. "Neuroimaging Findings in Patients With COVID-19: a Systematic Review and Meta-Analysis." Korean Journal of Radiology, 2021.
Kim PH, Kim M, Suh CH, et al. Neuroimaging Findings in Patients with COVID-19: A Systematic Review and Meta-Analysis. Korean J Radiol. 2021.
Kim, P. H., Kim, M., Suh, C. H., Chung, S. R., Park, J. E., Kim, S. C., Choi, Y. J., Lee, J. H., Kim, H. S., Baek, J. H., Choi, C. G., & Kim, S. J. (2021). Neuroimaging Findings in Patients with COVID-19: A Systematic Review and Meta-Analysis. Korean Journal of Radiology. https://doi.org/10.3348/kjr.2021.0127
Kim PH, et al. Neuroimaging Findings in Patients With COVID-19: a Systematic Review and Meta-Analysis. Korean J Radiol. 2021 Jul 1; PubMed PMID: 34269530.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neuroimaging Findings in Patients with COVID-19: A Systematic Review and Meta-Analysis. AU - Kim,Pyeong Hwa, AU - Kim,Minjae, AU - Suh,Chong Hyun, AU - Chung,Sae Rom, AU - Park,Ji Eun, AU - Kim,Soo Chin, AU - Choi,Young Jun, AU - Lee,Jeong Hyun, AU - Kim,Ho Sung, AU - Baek,Jung Hwan, AU - Choi,Choong Gon, AU - Kim,Sang Joon, Y1 - 2021/07/01/ PY - 2021/02/15/received PY - 2021/03/31/revised PY - 2021/04/21/accepted PY - 2021/7/16/entrez PY - 2021/7/17/pubmed PY - 2021/7/17/medline KW - COVID-19 KW - Computed tomography KW - Magnetic resonance imaging KW - Meta-analysis KW - Neuroimaging JF - Korean journal of radiology JO - Korean J Radiol N2 - OBJECTIVE: Central nervous system involvement in coronavirus disease 2019 (COVID-19) has been increasingly reported. We performed a systematic review and meta-analysis to evaluate the incidence of radiologically demonstrated neurologic complications and detailed neuroimaging findings associated with COVID-19. MATERIALS AND METHODS: A systematic literature search of MEDLINE/PubMed and EMBASE databases was performed up to September 17, 2020, and studies evaluating neuroimaging findings of COVID-19 using brain CT or MRI were included. Several cohort-based outcomes, including the proportion of patients with abnormal neuroimaging findings related to COVID-19 were evaluated. The proportion of patients showing specific neuroimaging findings was also assessed. Subgroup analyses were also conducted focusing on critically ill COVID-19 patients and results from studies that used MRI as the only imaging modality. RESULTS: A total of 1394 COVID-19 patients who underwent neuroimaging from 17 studies were included; among them, 3.4% of the patients demonstrated COVID-19-related neuroimaging findings. Olfactory bulb abnormalities were the most commonly observed (23.1%). The predominant cerebral neuroimaging finding was white matter abnormality (17.6%), followed by acute/subacute ischemic infarction (16.0%), and encephalopathy (13.0%). Significantly more critically ill patients had COVID-19-related neuroimaging findings than other patients (9.1% vs. 1.6%; p = 0.029). The type of imaging modality used did not significantly affect the proportion of COVID-19-related neuroimaging findings. CONCLUSION: Abnormal neuroimaging findings were occasionally observed in COVID-19 patients. Olfactory bulb abnormalities were the most commonly observed finding. Critically ill patients showed abnormal neuroimaging findings more frequently than the other patient groups. White matter abnormalities, ischemic infarctions, and encephalopathies were the common cerebral neuroimaging findings. SN - 2005-8330 UR - https://www.unboundmedicine.com/medline/citation/34269530/Neuroimaging_Findings_in_Patients_with_COVID-19:_A_Systematic_Review_and_Meta-Analysis. L2 - https://www.kjronline.org/DOIx.php?id=10.3348/kjr.2021.0127 DB - PRIME DP - Unbound Medicine ER -
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