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Coinfection with severe acute respiratory syndrome coronavirus-2 and other respiratory viruses at a tertiary hospital in Korea.
J Clin Lab Anal. 2021 Aug; 35(8):e23868.JC

Abstract

BACKGROUND

Studies have reported coinfection of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the cause of coronavirus disease-2019 (COVID-19), with other viruses that cause respiratory tract infections (RTIs). We investigated the coinfection rate of SARS-CoV-2 and other RTI-causing viruses, and whether the cycle threshold (Ct) value of a real-time reverse transcriptase PCR (RT-PCR) differed when the coinfection occurred during the first wave of COVID-19 in Daegu, Republic of Korea, in 2020.

METHODS

After performing PCR for SARS-CoV-2, we additionally tested for the presence of RTI-causing viruses to check for coinfection. Subsequently, we identified the specific coexisting respiratory viruses and calculated the coinfection rate. In addition, based on the coinfection status, we compared the Ct values obtained from RT-PCR for SARS-CoV-2 in patients who tested positive for COVID-19 PCR.

RESULTS

Of 13,717 patients, 123 had positive results on COVID-19 PCR testing and six tested positive for an RTI-causing virus. Thus, the coinfection rate was 4.9%. There were no statistically significant differences in the mean Ct values of SARS-CoV-2 RT-PCR between coinfected and non-coinfected patients.

CONCLUSION

This study computed the coinfection rate of SARS-CoV-2 and RTI-causing viruses and revealed that the mean Ct values in SARS-CoV-2 real-time RT-PCR did not differ according to the coinfection status.

Authors+Show Affiliations

Department of Laboratory Medicine, Yeungnam University Medical Center, Daegu, Korea.Department of Laboratory Medicine, Yeungnam University Medical Center, Daegu, Korea. Department of Laboratory Medicine, College of Medicine, Yeungnam University, Daegu, Korea.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

34273182

Citation

Kim, Zehwan, and Jong Ho Lee. "Coinfection With Severe Acute Respiratory Syndrome Coronavirus-2 and Other Respiratory Viruses at a Tertiary Hospital in Korea." Journal of Clinical Laboratory Analysis, vol. 35, no. 8, 2021, pp. e23868.
Kim Z, Lee JH. Coinfection with severe acute respiratory syndrome coronavirus-2 and other respiratory viruses at a tertiary hospital in Korea. J Clin Lab Anal. 2021;35(8):e23868.
Kim, Z., & Lee, J. H. (2021). Coinfection with severe acute respiratory syndrome coronavirus-2 and other respiratory viruses at a tertiary hospital in Korea. Journal of Clinical Laboratory Analysis, 35(8), e23868. https://doi.org/10.1002/jcla.23868
Kim Z, Lee JH. Coinfection With Severe Acute Respiratory Syndrome Coronavirus-2 and Other Respiratory Viruses at a Tertiary Hospital in Korea. J Clin Lab Anal. 2021;35(8):e23868. PubMed PMID: 34273182.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Coinfection with severe acute respiratory syndrome coronavirus-2 and other respiratory viruses at a tertiary hospital in Korea. AU - Kim,Zehwan, AU - Lee,Jong Ho, Y1 - 2021/07/17/ PY - 2021/05/19/revised PY - 2021/04/26/received PY - 2021/05/21/accepted PY - 2021/7/18/pubmed PY - 2021/8/31/medline PY - 2021/7/17/entrez KW - COVID-19 KW - SARS-CoV-2 KW - coinfection KW - cycle threshold KW - real-time RT-PCR SP - e23868 EP - e23868 JF - Journal of clinical laboratory analysis JO - J Clin Lab Anal VL - 35 IS - 8 N2 - BACKGROUND: Studies have reported coinfection of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the cause of coronavirus disease-2019 (COVID-19), with other viruses that cause respiratory tract infections (RTIs). We investigated the coinfection rate of SARS-CoV-2 and other RTI-causing viruses, and whether the cycle threshold (Ct) value of a real-time reverse transcriptase PCR (RT-PCR) differed when the coinfection occurred during the first wave of COVID-19 in Daegu, Republic of Korea, in 2020. METHODS: After performing PCR for SARS-CoV-2, we additionally tested for the presence of RTI-causing viruses to check for coinfection. Subsequently, we identified the specific coexisting respiratory viruses and calculated the coinfection rate. In addition, based on the coinfection status, we compared the Ct values obtained from RT-PCR for SARS-CoV-2 in patients who tested positive for COVID-19 PCR. RESULTS: Of 13,717 patients, 123 had positive results on COVID-19 PCR testing and six tested positive for an RTI-causing virus. Thus, the coinfection rate was 4.9%. There were no statistically significant differences in the mean Ct values of SARS-CoV-2 RT-PCR between coinfected and non-coinfected patients. CONCLUSION: This study computed the coinfection rate of SARS-CoV-2 and RTI-causing viruses and revealed that the mean Ct values in SARS-CoV-2 real-time RT-PCR did not differ according to the coinfection status. SN - 1098-2825 UR - https://www.unboundmedicine.com/medline/citation/34273182/Coinfection_with_severe_acute_respiratory_syndrome_coronavirus-2_and_other_respiratory_viruses_at_a_tertiary_hospital_in_Korea. L2 - https://doi.org/10.1002/jcla.23868 DB - PRIME DP - Unbound Medicine ER -