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Potential Therapeutic Targets and Vaccine Development for SARS-CoV-2/COVID-19 Pandemic Management: A Review on the Recent Update.
Front Immunol. 2021; 12:658519.FI

Abstract

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a highly pathogenic novel virus that has caused a massive pandemic called coronavirus disease 2019 (COVID-19) worldwide. Wuhan, a city in China became the epicenter of the outbreak of COVID-19 in December 2019. The disease was declared a pandemic globally by the World Health Organization (WHO) on 11 March 2020. SARS-CoV-2 is a beta CoV of the Coronaviridae family which usually causes respiratory symptoms that resemble common cold. Multiple countries have experienced multiple waves of the disease and scientific experts are consistently working to find answers to several unresolved questions, with the aim to find the most suitable ways to contain the virus. Furthermore, potential therapeutic strategies and vaccine development for COVID-19 management are also considered. Currently, substantial efforts have been made to develop successful and safe treatments and SARS-CoV-2 vaccines. Some vaccines, such as inactivated vaccines, nucleic acid-based, and vector-based vaccines, have entered phase 3 clinical trials. Additionally, diverse small molecule drugs, peptides and antibodies are being developed to treat COVID-19. We present here an overview of the virus interaction with the host and environment and anti-CoV therapeutic strategies; including vaccines and other methodologies, designed for prophylaxis and treatment of SARS-CoV-2 infection with the hope that this integrative analysis could help develop novel therapeutic approaches against COVID-19.

Authors+Show Affiliations

Department of Life Sciences, National Institute for Biotechnology in the Negev, Ben-Gurion University of the Negev, Beer-Sheva, Israel.Discipline of Biosciences and Biomedical Engineering, Indian Institute of Technology Indore, Indore, India.Discipline of Biosciences and Biomedical Engineering, Indian Institute of Technology Indore, Indore, India.Discipline of Biosciences and Biomedical Engineering, Indian Institute of Technology Indore, Indore, India.Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St. John's University, Queens, NY, United States.Department of Molecular and Cellular Engineering, Jacob Institute of Biotechnology and Bioengineering, Sam Higginbottom University of Agriculture, Technology and Sciences, Prayagraj, India.Instituto de Productos Naturales y Agrobiología (IPNA), Consejo Superior de Investigaciones científicas (CSIS), Santa Cruz de Tenerife, Spain.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

34276652

Citation

Anand, Uttpal, et al. "Potential Therapeutic Targets and Vaccine Development for SARS-CoV-2/COVID-19 Pandemic Management: a Review On the Recent Update." Frontiers in Immunology, vol. 12, 2021, p. 658519.
Anand U, Jakhmola S, Indari O, et al. Potential Therapeutic Targets and Vaccine Development for SARS-CoV-2/COVID-19 Pandemic Management: A Review on the Recent Update. Front Immunol. 2021;12:658519.
Anand, U., Jakhmola, S., Indari, O., Jha, H. C., Chen, Z. S., Tripathi, V., & Pérez de la Lastra, J. M. (2021). Potential Therapeutic Targets and Vaccine Development for SARS-CoV-2/COVID-19 Pandemic Management: A Review on the Recent Update. Frontiers in Immunology, 12, 658519. https://doi.org/10.3389/fimmu.2021.658519
Anand U, et al. Potential Therapeutic Targets and Vaccine Development for SARS-CoV-2/COVID-19 Pandemic Management: a Review On the Recent Update. Front Immunol. 2021;12:658519. PubMed PMID: 34276652.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Potential Therapeutic Targets and Vaccine Development for SARS-CoV-2/COVID-19 Pandemic Management: A Review on the Recent Update. AU - Anand,Uttpal, AU - Jakhmola,Shweta, AU - Indari,Omkar, AU - Jha,Hem Chandra, AU - Chen,Zhe-Sheng, AU - Tripathi,Vijay, AU - Pérez de la Lastra,José M, Y1 - 2021/06/30/ PY - 2021/01/25/received PY - 2021/06/07/accepted PY - 2021/7/19/entrez PY - 2021/7/20/pubmed PY - 2021/7/31/medline KW - COVID-19 KW - antibodies KW - peptide KW - therapeutic targets KW - treatment KW - vaccine SP - 658519 EP - 658519 JF - Frontiers in immunology JO - Front Immunol VL - 12 N2 - Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a highly pathogenic novel virus that has caused a massive pandemic called coronavirus disease 2019 (COVID-19) worldwide. Wuhan, a city in China became the epicenter of the outbreak of COVID-19 in December 2019. The disease was declared a pandemic globally by the World Health Organization (WHO) on 11 March 2020. SARS-CoV-2 is a beta CoV of the Coronaviridae family which usually causes respiratory symptoms that resemble common cold. Multiple countries have experienced multiple waves of the disease and scientific experts are consistently working to find answers to several unresolved questions, with the aim to find the most suitable ways to contain the virus. Furthermore, potential therapeutic strategies and vaccine development for COVID-19 management are also considered. Currently, substantial efforts have been made to develop successful and safe treatments and SARS-CoV-2 vaccines. Some vaccines, such as inactivated vaccines, nucleic acid-based, and vector-based vaccines, have entered phase 3 clinical trials. Additionally, diverse small molecule drugs, peptides and antibodies are being developed to treat COVID-19. We present here an overview of the virus interaction with the host and environment and anti-CoV therapeutic strategies; including vaccines and other methodologies, designed for prophylaxis and treatment of SARS-CoV-2 infection with the hope that this integrative analysis could help develop novel therapeutic approaches against COVID-19. SN - 1664-3224 UR - https://www.unboundmedicine.com/medline/citation/34276652/Potential_Therapeutic_Targets_and_Vaccine_Development_for_SARS_CoV_2/COVID_19_Pandemic_Management:_A_Review_on_the_Recent_Update_ DB - PRIME DP - Unbound Medicine ER -