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Simple prognostic factors and change of inflammatory markers in patients with severe coronavirus disease 2019: a single-center observational study.
Acute Med Surg. 2021 Jan-Dec; 8(1):e683.AM

Abstract

Aim

The aim of this study was to investigate the prognostic factors and evaluate the change in inflammatory markers of patients with coronavirus disease 2019 (COVID-19) requiring mechanical ventilation.

Methods

This retrospective observational study conducted from April 1, 2020, to February 18, 2021, included 97 adult patients who required mechanical ventilation for severe COVID-19 pneumonia and excluded nonintubated patients with a positive COVID-19 polymerase chain reaction test and those who had any obvious bacterial infection on admission. All patients were followed up to discharge or death. We obtained clinical information and laboratory data including levels of presepsin, interleukin-6, procalcitonin, and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibody every day. Poor outcome was defined as death or receiving a tracheostomy during hospitalization, and favorable outcome was defined as discharge after extubation.

Results

Differences (median [interquartile range]) were detected in age (76 [70-82] versus 66 [55-74] years), day from the onset of first symptoms to admission for mechanical ventilation (5 [3-7] versus 10 [8-12] days), and P/F ratio (i.e., ratio of arterial oxygen concentration to the fraction of inspired oxygen) after intubation (186 [149-251] versus 236 [180-296]) in patients with poor outcome versus those with favorable outcome on admission. Serum SARS-CoV-2 antibody levels had already increased on admission in patients with favorable outcome. We determined the day from the onset of first symptoms to admission for mechanical ventilation to be one of the independent prognostic factors of patients with COVID-19 (adjusted odds ratio 0.69, confidence interval 0.56-0.85).

Conclusion

These results may contribute to understanding the mechanism of progression in severe COVID-19 and may be helpful in devising an effective therapeutic strategy.

Authors+Show Affiliations

Osaka Prefectural Nakakawachi Emergency and Critical Care Center Higashiosaka Osaka Japan.Osaka Prefectural Nakakawachi Emergency and Critical Care Center Higashiosaka Osaka Japan.Osaka Prefectural Nakakawachi Emergency and Critical Care Center Higashiosaka Osaka Japan.Osaka Prefectural Nakakawachi Emergency and Critical Care Center Higashiosaka Osaka Japan.Osaka Prefectural Nakakawachi Emergency and Critical Care Center Higashiosaka Osaka Japan.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

34277014

Citation

Domi, Hisaya, et al. "Simple Prognostic Factors and Change of Inflammatory Markers in Patients With Severe Coronavirus Disease 2019: a Single-center Observational Study." Acute Medicine & Surgery, vol. 8, no. 1, 2021, pp. e683.
Domi H, Matsuura H, Kuroda M, et al. Simple prognostic factors and change of inflammatory markers in patients with severe coronavirus disease 2019: a single-center observational study. Acute Med Surg. 2021;8(1):e683.
Domi, H., Matsuura, H., Kuroda, M., Yoshida, M., & Yamamura, H. (2021). Simple prognostic factors and change of inflammatory markers in patients with severe coronavirus disease 2019: a single-center observational study. Acute Medicine & Surgery, 8(1), e683. https://doi.org/10.1002/ams2.683
Domi H, et al. Simple Prognostic Factors and Change of Inflammatory Markers in Patients With Severe Coronavirus Disease 2019: a Single-center Observational Study. Acute Med Surg. 2021 Jan-Dec;8(1):e683. PubMed PMID: 34277014.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Simple prognostic factors and change of inflammatory markers in patients with severe coronavirus disease 2019: a single-center observational study. AU - Domi,Hisaya, AU - Matsuura,Hiroshi, AU - Kuroda,Maiko, AU - Yoshida,Motoharu, AU - Yamamura,Hitoshi, Y1 - 2021/07/12/ PY - 2021/04/13/received PY - 2021/06/24/accepted PY - 2021/7/19/entrez PY - 2021/7/20/pubmed PY - 2021/7/20/medline KW - IL‐6 KW - SARS‐CoV‐2 antibody KW - mechanical ventilation KW - presepsin SP - e683 EP - e683 JF - Acute medicine & surgery JO - Acute Med Surg VL - 8 IS - 1 N2 - Aim: The aim of this study was to investigate the prognostic factors and evaluate the change in inflammatory markers of patients with coronavirus disease 2019 (COVID-19) requiring mechanical ventilation. Methods: This retrospective observational study conducted from April 1, 2020, to February 18, 2021, included 97 adult patients who required mechanical ventilation for severe COVID-19 pneumonia and excluded nonintubated patients with a positive COVID-19 polymerase chain reaction test and those who had any obvious bacterial infection on admission. All patients were followed up to discharge or death. We obtained clinical information and laboratory data including levels of presepsin, interleukin-6, procalcitonin, and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibody every day. Poor outcome was defined as death or receiving a tracheostomy during hospitalization, and favorable outcome was defined as discharge after extubation. Results: Differences (median [interquartile range]) were detected in age (76 [70-82] versus 66 [55-74] years), day from the onset of first symptoms to admission for mechanical ventilation (5 [3-7] versus 10 [8-12] days), and P/F ratio (i.e., ratio of arterial oxygen concentration to the fraction of inspired oxygen) after intubation (186 [149-251] versus 236 [180-296]) in patients with poor outcome versus those with favorable outcome on admission. Serum SARS-CoV-2 antibody levels had already increased on admission in patients with favorable outcome. We determined the day from the onset of first symptoms to admission for mechanical ventilation to be one of the independent prognostic factors of patients with COVID-19 (adjusted odds ratio 0.69, confidence interval 0.56-0.85). Conclusion: These results may contribute to understanding the mechanism of progression in severe COVID-19 and may be helpful in devising an effective therapeutic strategy. SN - 2052-8817 UR - https://www.unboundmedicine.com/medline/citation/34277014/Simple_prognostic_factors_and_change_of_inflammatory_markers_in_patients_with_severe_coronavirus_disease_2019:_a_single-center_observational_study. L2 - https://doi.org/10.1002/ams2.683 DB - PRIME DP - Unbound Medicine ER -
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