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New-Onset Neurologic Symptoms and Related Neuro-Oncologic Lesions Discovered After COVID-19 Vaccination: Two Neurosurgical Cases and Review of Post-Vaccine Inflammatory Responses.
Cureus. 2021 Jun; 13(6):e15664.C

Abstract

A global effort is underway to distribute coronavirus disease 2019 (COVID-19) vaccines to limit the crisis. Although adverse events related to vaccination are rare, there have been cases of new-onset neurologic symptoms following vaccination. We present two cases of new-onset neurologic symptoms post-vaccination that, upon further workup, revealed two different neuro-oncologic processes requiring neurosurgical intervention and further treatment. We hypothesize that despite these processes being unrelated to vaccination, the COVID-19 vaccines may induce an inflammatory cascade with the ability to uncover underlying sinister pathology. Our report therefore emphasizes the need for careful evaluation in the setting of new-onset neurologic symptoms after COVID-19 vaccination.

Authors+Show Affiliations

Neurosurgery, Lenox Hill Hospital/Donald and Barbara Zucker School of Medicine, New York, USA.Neurosurgery, Lenox Hill Hospital/Donald and Barbara Zucker School of Medicine, New York, USA.Neurosurgery, Lenox Hill Hospital/Donald and Barbara Zucker School of Medicine, New York, USA.Neurosurgery, Lenox Hill Hospital/Donald and Barbara Zucker School of Medicine, New York, USA.Neurosurgery, Lenox Hill Hospital/Donald and Barbara Zucker School of Medicine, New York, USA.Neurosurgery, Lenox Hill Hospital/Donald and Barbara Zucker School of Medicine, New York, USA.

Pub Type(s)

Case Reports

Language

eng

PubMed ID

34277256

Citation

Einstein, Evan H., et al. "New-Onset Neurologic Symptoms and Related Neuro-Oncologic Lesions Discovered After COVID-19 Vaccination: Two Neurosurgical Cases and Review of Post-Vaccine Inflammatory Responses." Cureus, vol. 13, no. 6, 2021, pp. e15664.
Einstein EH, Shahzadi A, Desir L, et al. New-Onset Neurologic Symptoms and Related Neuro-Oncologic Lesions Discovered After COVID-19 Vaccination: Two Neurosurgical Cases and Review of Post-Vaccine Inflammatory Responses. Cureus. 2021;13(6):e15664.
Einstein, E. H., Shahzadi, A., Desir, L., Katz, J., Boockvar, J., & D'Amico, R. (2021). New-Onset Neurologic Symptoms and Related Neuro-Oncologic Lesions Discovered After COVID-19 Vaccination: Two Neurosurgical Cases and Review of Post-Vaccine Inflammatory Responses. Cureus, 13(6), e15664. https://doi.org/10.7759/cureus.15664
Einstein EH, et al. New-Onset Neurologic Symptoms and Related Neuro-Oncologic Lesions Discovered After COVID-19 Vaccination: Two Neurosurgical Cases and Review of Post-Vaccine Inflammatory Responses. Cureus. 2021;13(6):e15664. PubMed PMID: 34277256.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - New-Onset Neurologic Symptoms and Related Neuro-Oncologic Lesions Discovered After COVID-19 Vaccination: Two Neurosurgical Cases and Review of Post-Vaccine Inflammatory Responses. AU - Einstein,Evan H, AU - Shahzadi,Andia, AU - Desir,Likowsky, AU - Katz,Joshua, AU - Boockvar,John, AU - D'Amico,Randy, Y1 - 2021/06/15/ PY - 2021/06/15/accepted PY - 2021/7/19/entrez PY - 2021/7/20/pubmed PY - 2021/7/20/medline KW - covid-19 vaccine KW - glioma KW - inflammation KW - melanoma KW - neurological symptoms SP - e15664 EP - e15664 JF - Cureus JO - Cureus VL - 13 IS - 6 N2 - A global effort is underway to distribute coronavirus disease 2019 (COVID-19) vaccines to limit the crisis. Although adverse events related to vaccination are rare, there have been cases of new-onset neurologic symptoms following vaccination. We present two cases of new-onset neurologic symptoms post-vaccination that, upon further workup, revealed two different neuro-oncologic processes requiring neurosurgical intervention and further treatment. We hypothesize that despite these processes being unrelated to vaccination, the COVID-19 vaccines may induce an inflammatory cascade with the ability to uncover underlying sinister pathology. Our report therefore emphasizes the need for careful evaluation in the setting of new-onset neurologic symptoms after COVID-19 vaccination. SN - 2168-8184 UR - https://www.unboundmedicine.com/medline/citation/34277256/New-Onset_Neurologic_Symptoms_and_Related_Neuro-Oncologic_Lesions_Discovered_After_COVID-19_Vaccination:_Two_Neurosurgical_Cases_and_Review_of_Post-Vaccine_Inflammatory_Responses. L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/34277256/ DB - PRIME DP - Unbound Medicine ER -
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