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Impacts of diabetes mellitus on clinical and para-clinical parameters among COVID-19 patients.
J Diabetes Metab Disord. 2021 Jul 14 [Online ahead of print]JD

Abstract

Purpose

Diabetes has several adverse effects on patients with coronavirus disease 2019 (COVID-19); however, the determinants of this effect are still poorly understood. It is tried in current study to evaluate impacts of type 2 diabetes, with and without other comorbidities, on the clinical, para-clinical, and outcome parameters among COVID-19 patients.

Methods

A case series was applied, which involved 406 COVID-19 patients admitted in the city of Shiraz, south-central Iran, from February 20 to April 29, 2020. Demographic data, medical history, laboratory finding, chest computed tomography (CT) scan reports, and clinical outcomes of patients with and without type 2 diabetes were compared.

Results

Results of the above-mentioned comparison showed that comorbidities such as HTN (35.5% vs. 13.7%, p < 0.001) and CVDs (26.2% vs. 13.4%, P = 0.002) were significantly more prevalent among the diabetic patients. Also, there was not any considerable difference between the chest CT severity parameters of both groups. After excluding all of the comorbidities except diabetes, it was found that the diabetic COVID-19 patients without other comorbidities had lower oxygen saturation level (P < 0.001), higher AST level (P = 0.037), higher BUN (P = 0.005), higher WBC counts (P = 0.025), lower lymphocyte counts (P = 0.029), and longer ICU admission duration (0.72 ± 2.83 vs. 1.71 ± 4.68, P = 0.046).

Conclusion

The diabetic COVID patients are at higher risks of hypoxemia, longer ICU stays, and more renal and hepatic dysfunction. These achievements could be useful in order to prevent the deterioration of clinical conditions among diabetic COVID-19 patients; also, they have to be considered in the management strategies.

Authors+Show Affiliations

Health Policy Research Center, Institute of Heath, Shiraz University of Medical Sciences, Shiraz, Fars Iran.Endocrinology and Metabolism Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.Health Policy Research Center, Institute of Heath, Shiraz University of Medical Sciences, Shiraz, Fars Iran.Radiology Department, Shiraz University of Medical Sciences, Shiraz, Iran.Endocrinology and Metabolism Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

34277497

Citation

Estedlal, AliReza, et al. "Impacts of Diabetes Mellitus On Clinical and Para-clinical Parameters Among COVID-19 Patients." Journal of Diabetes and Metabolic Disorders, 2021, pp. 1-9.
Estedlal A, Jeddi M, Heydari ST, et al. Impacts of diabetes mellitus on clinical and para-clinical parameters among COVID-19 patients. J Diabetes Metab Disord. 2021.
Estedlal, A., Jeddi, M., Heydari, S. T., Jahromi, M. G., & Dabbaghmanesh, M. H. (2021). Impacts of diabetes mellitus on clinical and para-clinical parameters among COVID-19 patients. Journal of Diabetes and Metabolic Disorders, 1-9. https://doi.org/10.1007/s40200-021-00844-w
Estedlal A, et al. Impacts of Diabetes Mellitus On Clinical and Para-clinical Parameters Among COVID-19 Patients. J Diabetes Metab Disord. 2021 Jul 14;1-9. PubMed PMID: 34277497.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impacts of diabetes mellitus on clinical and para-clinical parameters among COVID-19 patients. AU - Estedlal,AliReza, AU - Jeddi,Marjan, AU - Heydari,Seyed Taghi, AU - Jahromi,Mehdi Ghaderian, AU - Dabbaghmanesh,Mohammad Hossein, Y1 - 2021/07/14/ PY - 2021/02/01/received PY - 2021/06/21/accepted PY - 2021/7/19/entrez PY - 2021/7/20/pubmed PY - 2021/7/20/medline KW - COVID-19 KW - Comorbidity KW - Diabetes Mellitus KW - Hypoxemia SP - 1 EP - 9 JF - Journal of diabetes and metabolic disorders JO - J Diabetes Metab Disord N2 - Purpose: Diabetes has several adverse effects on patients with coronavirus disease 2019 (COVID-19); however, the determinants of this effect are still poorly understood. It is tried in current study to evaluate impacts of type 2 diabetes, with and without other comorbidities, on the clinical, para-clinical, and outcome parameters among COVID-19 patients. Methods: A case series was applied, which involved 406 COVID-19 patients admitted in the city of Shiraz, south-central Iran, from February 20 to April 29, 2020. Demographic data, medical history, laboratory finding, chest computed tomography (CT) scan reports, and clinical outcomes of patients with and without type 2 diabetes were compared. Results: Results of the above-mentioned comparison showed that comorbidities such as HTN (35.5% vs. 13.7%, p < 0.001) and CVDs (26.2% vs. 13.4%, P = 0.002) were significantly more prevalent among the diabetic patients. Also, there was not any considerable difference between the chest CT severity parameters of both groups. After excluding all of the comorbidities except diabetes, it was found that the diabetic COVID-19 patients without other comorbidities had lower oxygen saturation level (P < 0.001), higher AST level (P = 0.037), higher BUN (P = 0.005), higher WBC counts (P = 0.025), lower lymphocyte counts (P = 0.029), and longer ICU admission duration (0.72 ± 2.83 vs. 1.71 ± 4.68, P = 0.046). Conclusion: The diabetic COVID patients are at higher risks of hypoxemia, longer ICU stays, and more renal and hepatic dysfunction. These achievements could be useful in order to prevent the deterioration of clinical conditions among diabetic COVID-19 patients; also, they have to be considered in the management strategies. SN - 2251-6581 UR - https://www.unboundmedicine.com/medline/citation/34277497/Impacts_of_diabetes_mellitus_on_clinical_and_para-clinical_parameters_among_COVID-19_patients. L2 - https://jdmdonline.biomedcentral.com/articles/10.1007/s40200-021-00844-w DB - PRIME DP - Unbound Medicine ER -
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