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Nationwide population-based surveys of Iranian COVID-19 Serological Surveillance (ICS) program: The surveys protocol.
Med J Islam Repub Iran. 2021; 35:61.MJ

Abstract

Background: Serological surveillance of COVID-19 through conducting repetitive population-based surveys can be useful in estimating and monitoring changes in the prevalence of infection across the country. This paper presents the protocol of nationwide population-based surveys of the Iranian COVID-19 Serological Surveillance (ICS) program. Methods: The target population of the surveys is all individuals ≥6 years in Iran. Stratified random sampling will be used to select participants from those registered in the primary health care electronic record systems in Iran. The strata are the 31 provinces of the country, in which sampling will be done through simple random sampling. The sample size is estimated 858 individuals for each province (except for Tehran province, which is 2574) at the first survey. It will be recalculated for the next surveys based on the findings of the first survey. The participants will be invited by the community health workers to the safe blood sampling centers at the district level. After obtaining written informed consent, 10 mL of venous blood will be taken from the participants. The blood samples will be transferred to selected reference laboratories in order to test IgG and IgM antibodies against COVID-19 using an Iranian SARS-CoV-2 ELISA Kit (Pishtaz Teb). A serologically positive test is defined as a positive IgG, IgM, or both. After adjusting for the measurement error of the laboratory test, nonresponse bias, and sampling design, the prevalence of COVID-19 will be estimated at the provincial and national levels. Also, the approximate incidence rate of infection will be calculated based on the data of both consecutive surveys. Conclusion: The implementation of these surveys will provide a comprehensive and clear picture of the magnitude of COVID-19 infection and its trend over time for health policymakers at the national and subnational levels.

Authors+Show Affiliations

Osteoporosis Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.Department of Epidemiology and Biostatistics, Research Centre for Emerging and Reemerging Infectious Diseases, Pasteur Institute of Iran, Tehran, Iran.Prevention of Metabolic Disorders Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Department of Biostatistics and Epidemiology, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Reference Health Laboratory, Ministry of Health and Medical Education, Tehran, Iran.Departments of Immunology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Deputy of Health, Ministry of Health and Medical Education, Tehran, Iran.Reference Health Laboratory, Ministry of Health and Medical Education, Tehran, Iran.National HIV/AIDS care and treatment advisor, Center for Communicable Disease Control, Ministry of Health and Medical Education, Tehran, Iran.HIV/STI Control Department, Center for Communicable Disease Control, Ministry of Health and Medical Education, Tehran, Iran.Virology Deportment, Pasteur Institute of Iran, Tehran, Iran.Tabriz Health Services Management Research Center, Iranian Center of Excellence in Health Management, Tabriz University of Medical Sciences, Tabriz, Iran.Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.Department of Epidemiology and Biostatistics, Pasteur Institute of Iran, Tehran, Iran.Endocrinology Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.Departments of Immunology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.Osteoporosis Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

34277498

Citation

Khalagi, Kazem, et al. "Nationwide Population-based Surveys of Iranian COVID-19 Serological Surveillance (ICS) Program: the Surveys Protocol." Medical Journal of the Islamic Republic of Iran, vol. 35, 2021, p. 61.
Khalagi K, Gharibzadeh S, Khalili D, et al. Nationwide population-based surveys of Iranian COVID-19 Serological Surveillance (ICS) program: The surveys protocol. Med J Islam Repub Iran. 2021;35:61.
Khalagi, K., Gharibzadeh, S., Khalili, D., Mirab Samiee, S., Hashemi, S. M., Aghamohamadi, S., Mir-Mohammad-Ali Roodaki, M., Tayeri, K., Namdari Tabar, H., Azadmanesh, K., Tabrizi, J. S., Mohammad, K., Goudarzi, S., Hajipour, F., Namaki, S., Raeisi, A., & Ostovar, A. (2021). Nationwide population-based surveys of Iranian COVID-19 Serological Surveillance (ICS) program: The surveys protocol. Medical Journal of the Islamic Republic of Iran, 35, 61. https://doi.org/10.47176/mjiri.35.61
Khalagi K, et al. Nationwide Population-based Surveys of Iranian COVID-19 Serological Surveillance (ICS) Program: the Surveys Protocol. Med J Islam Repub Iran. 2021;35:61. PubMed PMID: 34277498.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nationwide population-based surveys of Iranian COVID-19 Serological Surveillance (ICS) program: The surveys protocol. AU - Khalagi,Kazem, AU - Gharibzadeh,Safoora, AU - Khalili,Davood, AU - Mirab Samiee,Siamak, AU - Hashemi,Seyed Mahmoud, AU - Aghamohamadi,Saeide, AU - Mir-Mohammad-Ali Roodaki,Maryam, AU - Tayeri,Katayoun, AU - Namdari Tabar,Hengameh, AU - Azadmanesh,Kayhan, AU - Tabrizi,Jafar Sadegh, AU - Mohammad,Kazem, AU - Goudarzi,Samira, AU - Hajipour,Firoozeh, AU - Namaki,Saeid, AU - Raeisi,Alireza, AU - Ostovar,Afshin, Y1 - 2021/05/12/ PY - 2021/01/14/received PY - 2021/7/19/entrez PY - 2021/7/20/pubmed PY - 2021/7/20/medline KW - Antibody tests KW - COVID-19 KW - Iran KW - Nationwide KW - Population-based KW - Sero-prevalence KW - Serological KW - Surveillance KW - Survey SP - 61 EP - 61 JF - Medical journal of the Islamic Republic of Iran JO - Med J Islam Repub Iran VL - 35 N2 - Background: Serological surveillance of COVID-19 through conducting repetitive population-based surveys can be useful in estimating and monitoring changes in the prevalence of infection across the country. This paper presents the protocol of nationwide population-based surveys of the Iranian COVID-19 Serological Surveillance (ICS) program. Methods: The target population of the surveys is all individuals ≥6 years in Iran. Stratified random sampling will be used to select participants from those registered in the primary health care electronic record systems in Iran. The strata are the 31 provinces of the country, in which sampling will be done through simple random sampling. The sample size is estimated 858 individuals for each province (except for Tehran province, which is 2574) at the first survey. It will be recalculated for the next surveys based on the findings of the first survey. The participants will be invited by the community health workers to the safe blood sampling centers at the district level. After obtaining written informed consent, 10 mL of venous blood will be taken from the participants. The blood samples will be transferred to selected reference laboratories in order to test IgG and IgM antibodies against COVID-19 using an Iranian SARS-CoV-2 ELISA Kit (Pishtaz Teb). A serologically positive test is defined as a positive IgG, IgM, or both. After adjusting for the measurement error of the laboratory test, nonresponse bias, and sampling design, the prevalence of COVID-19 will be estimated at the provincial and national levels. Also, the approximate incidence rate of infection will be calculated based on the data of both consecutive surveys. Conclusion: The implementation of these surveys will provide a comprehensive and clear picture of the magnitude of COVID-19 infection and its trend over time for health policymakers at the national and subnational levels. SN - 1016-1430 UR - https://www.unboundmedicine.com/medline/citation/34277498/Nationwide_population-based_surveys_of_Iranian_COVID-19_Serological_Surveillance_(ICS)_program:_The_surveys_protocol. L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/34277498/ DB - PRIME DP - Unbound Medicine ER -