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Pharmacotherapy in Coronavirus Disease 2019 and Risk of Secondary Infections: A Single-Center Case Series and Narrative Review.
Crit Care Explor. 2021 Jul; 3(7):e0492.CC

Abstract

Since the onset of the coronavirus disease 2019 pandemic, immune modulators have been considered front-line candidates for the management of patients presenting with clinical symptoms secondary to severe acute respiratory syndrome coronavirus 2 infection. Although heavy emphasis has been placed on early clinical efficacy, we sought to evaluate the impact of pharmacologic approach to coronavirus disease 2019 within the ICU on secondary infections and clinical outcomes.

DATA SOURCES

PubMed (inception to March 2021) database search and manual selection of bibliographies from selected articles.

STUDY SELECTION AND DATA EXTRACTION

Articles relevant to coronavirus disease 2019, management of severe acute respiratory syndrome coronavirus 2-associated respiratory failure, and prevalence of secondary infections with pharmacotherapies were selected. The MeSH terms "COVID-19," "secondary infection," "SARS-CoV-2," "tocilizumab," and "corticosteroids" were used for article identification. Articles were narratively synthesized for this review.

DATA SYNTHESIS

Current data surrounding the use of tocilizumab and/or corticosteroids for coronavirus disease 2019 management are limited given the short follow-up period and conflicting results between studies. Further complicating the understanding of immune modulator role is the lack of definitive understanding of clinical impact of the immune response in coronavirus disease 2019.

CONCLUSIONS

Based on the current available literature, we suggest prolonged trials and follow-up intervals for those patients managed with immune modulating agents for the management of coronavirus disease 2019.

Authors+Show Affiliations

Department of Pharmacy Practice, University of Kentucky, College of Pharmacy, Lexington, KY.Department of Pharmacy Practice, University of Kentucky, College of Pharmacy, Lexington, KY.Department of Pharmacy Practice, University of Kentucky, College of Pharmacy, Lexington, KY.Department of Pharmacy Practice, University of Kentucky, College of Pharmacy, Lexington, KY.Department of Pharmacy Practice, University of Kentucky, College of Pharmacy, Lexington, KY.Department of Pharmacy Practice, University of Kentucky, College of Pharmacy, Lexington, KY.Department of Pharmacy Practice, University of Kentucky, College of Pharmacy, Lexington, KY. Department of Pulmonary, Critical Care, and Sleep Medicine, University of Kentucky, College of Medicine, Lexington, KY.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

34278319

Citation

Behal, Michael, et al. "Pharmacotherapy in Coronavirus Disease 2019 and Risk of Secondary Infections: a Single-Center Case Series and Narrative Review." Critical Care Explorations, vol. 3, no. 7, 2021, pp. e0492.
Behal M, Barlow B, Mefford B, et al. Pharmacotherapy in Coronavirus Disease 2019 and Risk of Secondary Infections: A Single-Center Case Series and Narrative Review. Crit Care Explor. 2021;3(7):e0492.
Behal, M., Barlow, B., Mefford, B., Thompson Bastin, M. L., Donaldson, J. C., Laine, M., & Bissell, B. D. (2021). Pharmacotherapy in Coronavirus Disease 2019 and Risk of Secondary Infections: A Single-Center Case Series and Narrative Review. Critical Care Explorations, 3(7), e0492. https://doi.org/10.1097/CCE.0000000000000492
Behal M, et al. Pharmacotherapy in Coronavirus Disease 2019 and Risk of Secondary Infections: a Single-Center Case Series and Narrative Review. Crit Care Explor. 2021;3(7):e0492. PubMed PMID: 34278319.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pharmacotherapy in Coronavirus Disease 2019 and Risk of Secondary Infections: A Single-Center Case Series and Narrative Review. AU - Behal,Michael, AU - Barlow,Brooke, AU - Mefford,Breanne, AU - Thompson Bastin,Melissa L, AU - Donaldson,J Chris, AU - Laine,Melanie, AU - Bissell,Brittany D, Y1 - 2021/07/13/ PY - 2021/7/19/entrez PY - 2021/7/20/pubmed PY - 2021/7/20/medline KW - acute respiratory failure KW - coronavirus disease 2019 KW - immunomodulation KW - infectious disease KW - secondary infections SP - e0492 EP - e0492 JF - Critical care explorations JO - Crit Care Explor VL - 3 IS - 7 N2 - : Since the onset of the coronavirus disease 2019 pandemic, immune modulators have been considered front-line candidates for the management of patients presenting with clinical symptoms secondary to severe acute respiratory syndrome coronavirus 2 infection. Although heavy emphasis has been placed on early clinical efficacy, we sought to evaluate the impact of pharmacologic approach to coronavirus disease 2019 within the ICU on secondary infections and clinical outcomes. DATA SOURCES: PubMed (inception to March 2021) database search and manual selection of bibliographies from selected articles. STUDY SELECTION AND DATA EXTRACTION: Articles relevant to coronavirus disease 2019, management of severe acute respiratory syndrome coronavirus 2-associated respiratory failure, and prevalence of secondary infections with pharmacotherapies were selected. The MeSH terms "COVID-19," "secondary infection," "SARS-CoV-2," "tocilizumab," and "corticosteroids" were used for article identification. Articles were narratively synthesized for this review. DATA SYNTHESIS: Current data surrounding the use of tocilizumab and/or corticosteroids for coronavirus disease 2019 management are limited given the short follow-up period and conflicting results between studies. Further complicating the understanding of immune modulator role is the lack of definitive understanding of clinical impact of the immune response in coronavirus disease 2019. CONCLUSIONS: Based on the current available literature, we suggest prolonged trials and follow-up intervals for those patients managed with immune modulating agents for the management of coronavirus disease 2019. SN - 2639-8028 UR - https://www.unboundmedicine.com/medline/citation/34278319/Pharmacotherapy_in_Coronavirus_Disease_2019_and_Risk_of_Secondary_Infections:_A_Single-Center_Case_Series_and_Narrative_Review. L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=34278319.ui DB - PRIME DP - Unbound Medicine ER -