Citation
Zhang, Jialu, et al. "Boosting With Heterologous Vaccines Effectively Improves Protective Immune Responses of the Inactivated SARS-CoV-2 Vaccine." Emerging Microbes & Infections, vol. 10, no. 1, 2021, pp. 1598-1608.
Zhang J, He Q, An C, et al. Boosting with heterologous vaccines effectively improves protective immune responses of the inactivated SARS-CoV-2 vaccine. Emerg Microbes Infect. 2021;10(1):1598-1608.
Zhang, J., He, Q., An, C., Mao, Q., Gao, F., Bian, L., Wu, X., Wang, Q., Liu, P., Song, L., Huo, Y., Liu, S., Yan, X., Yang, J., Cui, B., Li, C., Wang, J., Liang, Z., & Xu, M. (2021). Boosting with heterologous vaccines effectively improves protective immune responses of the inactivated SARS-CoV-2 vaccine. Emerging Microbes & Infections, 10(1), 1598-1608. https://doi.org/10.1080/22221751.2021.1957401
Zhang J, et al. Boosting With Heterologous Vaccines Effectively Improves Protective Immune Responses of the Inactivated SARS-CoV-2 Vaccine. Emerg Microbes Infect. 2021;10(1):1598-1608. PubMed PMID: 34278956.
TY - JOUR
T1 - Boosting with heterologous vaccines effectively improves protective immune responses of the inactivated SARS-CoV-2 vaccine.
AU - Zhang,Jialu,
AU - He,Qian,
AU - An,Chaoqiang,
AU - Mao,Qunying,
AU - Gao,Fan,
AU - Bian,Lianlian,
AU - Wu,Xing,
AU - Wang,Qian,
AU - Liu,Pei,
AU - Song,Lifang,
AU - Huo,Yaqian,
AU - Liu,Siyuan,
AU - Yan,Xujia,
AU - Yang,Jinghuan,
AU - Cui,Bopei,
AU - Li,Changgui,
AU - Wang,Junzhi,
AU - Liang,Zhenglun,
AU - Xu,Miao,
PY - 2021/7/20/pubmed
PY - 2021/8/31/medline
PY - 2021/7/19/entrez
KW - Heterologous
KW - IgG subtypes
KW - SARS-CoV-2
KW - T cell response
KW - inactivated
KW - neutralizing antibody
KW - prime-boost
KW - vaccine
SP - 1598
EP - 1608
JF - Emerging microbes & infections
JO - Emerg Microbes Infect
VL - 10
IS - 1
N2 - Since the outbreak of COVID-19, a variety of vaccine platforms have been developed. Amongst these, inactivated vaccines have been authorized for emergency use or conditional marketing in many countries. To further enhance the protective immune responses in populations that have completed vaccination regimen, we investigated the immunogenic characteristics of different vaccine platforms and tried homologous or heterologous boost strategy post two doses of inactivated vaccines in a mouse model. Our results showed that the humoral and cellular immune responses induced by different vaccines when administered individually differ significantly. In particular, inactivated vaccines showed relatively lower level of neutralizing antibody and T cell responses, but a higher IgG2a/IgG1 ratio compared with other vaccines. Boosting with either recombinant subunit, adenovirus vectored or mRNA vaccine after two-doses of inactivated vaccine further improved both neutralizing antibody and Spike-specific Th1-type T cell responses compared to boosting with a third dose of inactivated vaccine. Our results provide new ideas for prophylactic inoculation strategy of SARS-CoV-2 vaccines.
SN - 2222-1751
UR - https://www.unboundmedicine.com/medline/citation/34278956/Boosting_with_heterologous_vaccines_effectively_improves_protective_immune_responses_of_the_inactivated_SARS_CoV_2_vaccine_
DB - PRIME
DP - Unbound Medicine
ER -
