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Potential Mechanisms of the SARS-CoV-2-induced AKI Progression to CKD: A Forward-Looking Perspective.
Iran J Kidney Dis. 2021 07; 15(4):243-255.IJ

Abstract

Coronavirus disease 2019 (COVID‑19) was identified in December 2019 and is still expanding in most parts of the world. The wide variety of affected organs is likely based upon the shared expression of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) important entry-receptor angiotensin-converting enzyme 2 (ACE2). For this reason, the broad distribution of ACE2 receptors in different tissues plays a crucial role in the multi-organ dysfunction and fatality due to COVID-19. Because of the high prevalence of acute kidney injury (AKI) in patients with COVID-19, we review the molecular understanding into viral infection mechanisms and implications for AKI. Furthermore, mechanisms of the AKI to chronic kidney disease (CKD) progression, such as the relative contribution of immune cell reaction, fibroblasts activation, endothelial dysfunction, and subsequent hypoxia may contribute to the association of AKI with worse outcomes during this virus pandemic. We highlight the state of the knowledge on SARS-CoV-2-dependent mechanisms for AKI and list the potential management choices for the prevention of AKI aggravation and the impending possibility of CKD. Finally, we intend to provide a much better understanding of why Coronavirus induces AKI and its subsequent progression to CKD in the coming years and further discuss the acute and long-term renal consequences.

Authors+Show Affiliations

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableShiraz Nephro-Urology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. roozbehj@sums.ac.ir.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

34278995

Citation

Karimi, Zeinab, et al. "Potential Mechanisms of the SARS-CoV-2-induced AKI Progression to CKD: a Forward-Looking Perspective." Iranian Journal of Kidney Diseases, vol. 15, no. 4, 2021, pp. 243-255.
Karimi Z, Masjedi F, Malekmakan L, et al. Potential Mechanisms of the SARS-CoV-2-induced AKI Progression to CKD: A Forward-Looking Perspective. Iran J Kidney Dis. 2021;15(4):243-255.
Karimi, Z., Masjedi, F., Malekmakan, L., Doostkam, A., Roozbeh, J., & Ghahramani, N. (2021). Potential Mechanisms of the SARS-CoV-2-induced AKI Progression to CKD: A Forward-Looking Perspective. Iranian Journal of Kidney Diseases, 15(4), 243-255.
Karimi Z, et al. Potential Mechanisms of the SARS-CoV-2-induced AKI Progression to CKD: a Forward-Looking Perspective. Iran J Kidney Dis. 2021;15(4):243-255. PubMed PMID: 34278995.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Potential Mechanisms of the SARS-CoV-2-induced AKI Progression to CKD: A Forward-Looking Perspective. AU - Karimi,Zeinab, AU - Masjedi,Fatemeh, AU - Malekmakan,Leila, AU - Doostkam,Aida, AU - Roozbeh,Jamshid, AU - Ghahramani,Nasrollah, PY - 2021/01/30/received PY - 2021/05/30/accepted PY - 2021/05/30/revised PY - 2021/7/19/entrez PY - 2021/7/20/pubmed PY - 2021/8/18/medline SP - 243 EP - 255 JF - Iranian journal of kidney diseases JO - Iran J Kidney Dis VL - 15 IS - 4 N2 - Coronavirus disease 2019 (COVID‑19) was identified in December 2019 and is still expanding in most parts of the world. The wide variety of affected organs is likely based upon the shared expression of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) important entry-receptor angiotensin-converting enzyme 2 (ACE2). For this reason, the broad distribution of ACE2 receptors in different tissues plays a crucial role in the multi-organ dysfunction and fatality due to COVID-19. Because of the high prevalence of acute kidney injury (AKI) in patients with COVID-19, we review the molecular understanding into viral infection mechanisms and implications for AKI. Furthermore, mechanisms of the AKI to chronic kidney disease (CKD) progression, such as the relative contribution of immune cell reaction, fibroblasts activation, endothelial dysfunction, and subsequent hypoxia may contribute to the association of AKI with worse outcomes during this virus pandemic. We highlight the state of the knowledge on SARS-CoV-2-dependent mechanisms for AKI and list the potential management choices for the prevention of AKI aggravation and the impending possibility of CKD. Finally, we intend to provide a much better understanding of why Coronavirus induces AKI and its subsequent progression to CKD in the coming years and further discuss the acute and long-term renal consequences. SN - 1735-8604 UR - https://www.unboundmedicine.com/medline/citation/34278995/Potential_Mechanisms_of_the_SARS-CoV-2-induced_AKI_Progression_to_CKD:_A_Forward-Looking_Perspective. L2 - http://www.ijkd.org/index.php/ijkd/article/view/6708/1301 DB - PRIME DP - Unbound Medicine ER -