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Genetic Aspects and Immune Responses in Covid-19: Important Organ Involvement.
Adv Exp Med Biol. 2021; 1327:3-22.AE

Abstract

In the last two decades, the world has experienced outbreaks of three major coronaviruses with high morbidity and mortality rates. The most recent of these started in the form of an unusual viral pneumonia in Wuhan, China, and now the world is facing a serious pandemic. This new disease has been called COVID-19 and is caused by the SARS-CoV-2 virus. Understanding the specific genetic and phenotypic structure of SARS-CoV-2 in COVID-19 pathogenesis is vital in finding appropriate drugs and vaccines. With this in mind, this review sheds light on the virology, genetics, immune-responses, and mechanism of action of this virus.

Authors+Show Affiliations

Department of Medical Genetics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.Department of Medical Genetics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Medical Genetics Research Center, Department of Medical Genetics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.Formerly UNICEF/UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases (TDR), World Health Organization, Geneva, Switzerland.Natural Products and Medicinal Plants Research Center, North Khorasan University of Medical Sciences, Bojnurd, Iran.Pharmaceutical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. Department of Health Information Technology, Neyshabur University of Medical Sciences, Neyshabur, Iran.Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran. amir_saheb2000@yahoo.com. Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. amir_saheb2000@yahoo.com. School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. amir_saheb2000@yahoo.com.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

34279825

Citation

Ghale-Noie, Zari Naderi, et al. "Genetic Aspects and Immune Responses in Covid-19: Important Organ Involvement." Advances in Experimental Medicine and Biology, vol. 1327, 2021, pp. 3-22.
Ghale-Noie ZN, Salmaninejad A, Bergquist R, et al. Genetic Aspects and Immune Responses in Covid-19: Important Organ Involvement. Adv Exp Med Biol. 2021;1327:3-22.
Ghale-Noie, Z. N., Salmaninejad, A., Bergquist, R., Mollazadeh, S., Hoseini, B., & Sahebkar, A. (2021). Genetic Aspects and Immune Responses in Covid-19: Important Organ Involvement. Advances in Experimental Medicine and Biology, 1327, 3-22. https://doi.org/10.1007/978-3-030-71697-4_1
Ghale-Noie ZN, et al. Genetic Aspects and Immune Responses in Covid-19: Important Organ Involvement. Adv Exp Med Biol. 2021;1327:3-22. PubMed PMID: 34279825.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Genetic Aspects and Immune Responses in Covid-19: Important Organ Involvement. AU - Ghale-Noie,Zari Naderi, AU - Salmaninejad,Arash, AU - Bergquist,Robert, AU - Mollazadeh,Samaneh, AU - Hoseini,Benyamin, AU - Sahebkar,Amirhossein, PY - 2021/7/19/entrez PY - 2021/7/20/pubmed PY - 2021/7/22/medline KW - 2019-nCoV KW - Covid-19 KW - Genetics KW - Immune-responses KW - Respiratory KW - SARS-CoV-2 SP - 3 EP - 22 JF - Advances in experimental medicine and biology JO - Adv Exp Med Biol VL - 1327 N2 - In the last two decades, the world has experienced outbreaks of three major coronaviruses with high morbidity and mortality rates. The most recent of these started in the form of an unusual viral pneumonia in Wuhan, China, and now the world is facing a serious pandemic. This new disease has been called COVID-19 and is caused by the SARS-CoV-2 virus. Understanding the specific genetic and phenotypic structure of SARS-CoV-2 in COVID-19 pathogenesis is vital in finding appropriate drugs and vaccines. With this in mind, this review sheds light on the virology, genetics, immune-responses, and mechanism of action of this virus. SN - 0065-2598 UR - https://www.unboundmedicine.com/medline/citation/34279825/Genetic_Aspects_and_Immune_Responses_in_Covid-19:_Important_Organ_Involvement. DB - PRIME DP - Unbound Medicine ER -