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Using Ozone Therapy as an Option for Treatment of COVID-19 Patients: A Scoping Review.
Adv Exp Med Biol. 2021; 1327:151-160.AE

Abstract

Recent investigations are seeking a novel treatment to control the new pandemic of coronavirus 19 (COVID-19). The aim of this systematic review was to study the effect of ozone therapy on COVID-19 patients and the available supporting evidence. Electronic databases including MEDLINE (via PubMed), EMBASE, Cochrane Library (CENTRAL), and TRIP, clinical trial registries, and preprint sources were searched for published evidence-based articles. In addition, manual searching was conducted for articles published up to April 6, 2020, using MeSH and free text keywords with no language limitation. Articles were screened, categorized, and extracted for relative data. Data were reported in a descriptive manner. Among 234 articles, 9 were selected for review of the inclusion criteria. No published original articles were found regarding the efficacy of ozone therapy on COVID-19. Five review studies were found in which the potential role of systemic ozone therapy was concluded to be effective in controlling COVID-19 because of its antiviral, oxygenation, anti-inflammatory, oxidation balancing, and immunomodulation effects. Three ongoing clinical trials were registered in China. A preliminary report of an ongoing study in Italy on 46 patients (11 intubated and 35 non-intubated) showed that in 39 (84%) of the patients, an improvement was seen. In spite of the promising background data, as well as the expert opinions and a preliminary report indicating the effectiveness of ozone, there is still not enough evidence to confirm this as a viable treatment option for COVID-19.

Authors+Show Affiliations

Research Center for Evidence-based- medicine, Iranian EBM Center: A Joanna Briggs Institute Affiliated Group, Tabriz University of Medical Sciences, Tabriz, Iran. Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.Student Research Committee, Gonabad University of Medical Sciences, Gonabad, Iran. Sepidehshayan76@gmail.com.Student Research Committee, Gonabad University of Medical Sciences, Gonabad, Iran.Student Research Committee, Gonabad University of Medical Sciences, Gonabad, Iran.Research Center for Evidence-based- medicine, Iranian EBM Center: A Joanna Briggs Institute Affiliated Group, Tabriz University of Medical Sciences, Tabriz, Iran.Research Center for Evidence-based- medicine, Iranian EBM Center: A Joanna Briggs Institute Affiliated Group, Tabriz University of Medical Sciences, Tabriz, Iran. Department of physical medicine and rehabilitation, faculty of medicine, Tabriz University of medical sciences, Tabriz, Iran.Research Center for Evidence-based- medicine, Iranian EBM Center: A Joanna Briggs Institute Affiliated Group, Tabriz University of Medical Sciences, Tabriz, Iran.Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran. amir_saheb2000@yahoo.com. Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. amir_saheb2000@yahoo.com. School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. amir_saheb2000@yahoo.com.

Pub Type(s)

Journal Article
Systematic Review

Language

eng

PubMed ID

34279836

Citation

Radvar, Sarvin, et al. "Using Ozone Therapy as an Option for Treatment of COVID-19 Patients: a Scoping Review." Advances in Experimental Medicine and Biology, vol. 1327, 2021, pp. 151-160.
Radvar S, Karkon-Shayan S, Motamed-Sanaye A, et al. Using Ozone Therapy as an Option for Treatment of COVID-19 Patients: A Scoping Review. Adv Exp Med Biol. 2021;1327:151-160.
Radvar, S., Karkon-Shayan, S., Motamed-Sanaye, A., Majidi, M., Hajebrahimi, S., Taleschian-Tabrizi, N., Pashazadeh, F., & Sahebkar, A. (2021). Using Ozone Therapy as an Option for Treatment of COVID-19 Patients: A Scoping Review. Advances in Experimental Medicine and Biology, 1327, 151-160. https://doi.org/10.1007/978-3-030-71697-4_12
Radvar S, et al. Using Ozone Therapy as an Option for Treatment of COVID-19 Patients: a Scoping Review. Adv Exp Med Biol. 2021;1327:151-160. PubMed PMID: 34279836.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Using Ozone Therapy as an Option for Treatment of COVID-19 Patients: A Scoping Review. AU - Radvar,Sarvin, AU - Karkon-Shayan,Sepideh, AU - Motamed-Sanaye,Ali, AU - Majidi,Mohammadreza, AU - Hajebrahimi,Sakineh, AU - Taleschian-Tabrizi,Negar, AU - Pashazadeh,Fariba, AU - Sahebkar,Amirhossein, PY - 2021/7/19/entrez PY - 2021/7/20/pubmed PY - 2021/7/22/medline KW - Autohemotherapy KW - COVID-19 KW - Ozone therapy KW - SARS-CoV-2 KW - Systematic review SP - 151 EP - 160 JF - Advances in experimental medicine and biology JO - Adv Exp Med Biol VL - 1327 N2 - Recent investigations are seeking a novel treatment to control the new pandemic of coronavirus 19 (COVID-19). The aim of this systematic review was to study the effect of ozone therapy on COVID-19 patients and the available supporting evidence. Electronic databases including MEDLINE (via PubMed), EMBASE, Cochrane Library (CENTRAL), and TRIP, clinical trial registries, and preprint sources were searched for published evidence-based articles. In addition, manual searching was conducted for articles published up to April 6, 2020, using MeSH and free text keywords with no language limitation. Articles were screened, categorized, and extracted for relative data. Data were reported in a descriptive manner. Among 234 articles, 9 were selected for review of the inclusion criteria. No published original articles were found regarding the efficacy of ozone therapy on COVID-19. Five review studies were found in which the potential role of systemic ozone therapy was concluded to be effective in controlling COVID-19 because of its antiviral, oxygenation, anti-inflammatory, oxidation balancing, and immunomodulation effects. Three ongoing clinical trials were registered in China. A preliminary report of an ongoing study in Italy on 46 patients (11 intubated and 35 non-intubated) showed that in 39 (84%) of the patients, an improvement was seen. In spite of the promising background data, as well as the expert opinions and a preliminary report indicating the effectiveness of ozone, there is still not enough evidence to confirm this as a viable treatment option for COVID-19. SN - 0065-2598 UR - https://www.unboundmedicine.com/medline/citation/34279836/Using_Ozone_Therapy_as_an_Option_for_Treatment_of_COVID-19_Patients:_A_Scoping_Review. L2 - https://dx.doi.org/10.1007/978-3-030-71697-4_12 DB - PRIME DP - Unbound Medicine ER -