Tags

Type your tag names separated by a space and hit enter

Severe reinfection with severe acute respiratory syndrome coronavirus 2 in a nursing home resident: a case report.
J Med Case Rep. 2021 Jul 20; 15(1):392.JM

Abstract

BACKGROUND

The topic of natural immunity related to severe acute respiratory syndrome coronavirus 2 remains controversial. Although evidence suggests postinfection immunity can be achieved, there have been reported cases of reinfection with similar or milder symptoms. Information on severe disease manifestation during reinfection is not known. We present a case of reinfection with a more severe presentation as compared with the initial infection.

CASE REPORT

We describe a white male patient from a nursing home who was reinfected with severe acute respiratory syndrome coronavirus 2 with severe disease manifesting as dyspnea, fevers, and encephalopathy with hypoxemic respiratory failure requiring intubation, elevated inflammatory markers, and lung infiltrates on imaging, after initially testing positive with mild symptoms 2 months prior to presentation. Notably, severe acute respiratory syndrome coronavirus 2 antibodies were detected, which indicated this was a coronavirus disease 2019 reinfection. After treatment with remdesivir, dexamethasone, and convalescent plasma, he was subsequently extubated and discharged home after 2 weeks.

CONCLUSION

It is not clear whether an initial infection with severe acute respiratory syndrome coronavirus 2 and recovery provides prolonged immunity beyond 2 months. Furthermore, even if antibodies are present, it does not guarantee an attenuated course during reinfection. Therefore, vaccination plays an important role in prevention. Long-term cohort studies will be needed to study the factors behind reinfection.

Authors+Show Affiliations

Department of Internal Medicine, University of Oklahoma Health Sciences Center, 800 Stanton L Young Blvd, Suite 6300, Oklahoma City, OK, 73104, USA. Nimrah.bader@gmail.com.Department of Internal Medicine, University of Oklahoma Health Sciences Center, 800 Stanton L Young Blvd, Suite 6300, Oklahoma City, OK, 73104, USA.Baylor Scott & White, Heart and Vascular Hospital, 7100 Oakmont Blvd, Suite 201, Fort Worth, Dallas, TX, 76132, USA.

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

34284812

Citation

Bader, Nimrah, et al. "Severe Reinfection With Severe Acute Respiratory Syndrome Coronavirus 2 in a Nursing Home Resident: a Case Report." Journal of Medical Case Reports, vol. 15, no. 1, 2021, p. 392.
Bader N, Khattab M, Farah F. Severe reinfection with severe acute respiratory syndrome coronavirus 2 in a nursing home resident: a case report. J Med Case Rep. 2021;15(1):392.
Bader, N., Khattab, M., & Farah, F. (2021). Severe reinfection with severe acute respiratory syndrome coronavirus 2 in a nursing home resident: a case report. Journal of Medical Case Reports, 15(1), 392. https://doi.org/10.1186/s13256-021-02958-4
Bader N, Khattab M, Farah F. Severe Reinfection With Severe Acute Respiratory Syndrome Coronavirus 2 in a Nursing Home Resident: a Case Report. J Med Case Rep. 2021 Jul 20;15(1):392. PubMed PMID: 34284812.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Severe reinfection with severe acute respiratory syndrome coronavirus 2 in a nursing home resident: a case report. AU - Bader,Nimrah, AU - Khattab,Mahmood, AU - Farah,Fahmi, Y1 - 2021/07/20/ PY - 2021/02/02/received PY - 2021/06/14/accepted PY - 2021/7/21/entrez PY - 2021/7/22/pubmed PY - 2021/7/23/medline KW - COVID-19 KW - Immunity KW - Reinfection KW - SARS-CoV-2 SP - 392 EP - 392 JF - Journal of medical case reports JO - J Med Case Rep VL - 15 IS - 1 N2 - BACKGROUND: The topic of natural immunity related to severe acute respiratory syndrome coronavirus 2 remains controversial. Although evidence suggests postinfection immunity can be achieved, there have been reported cases of reinfection with similar or milder symptoms. Information on severe disease manifestation during reinfection is not known. We present a case of reinfection with a more severe presentation as compared with the initial infection. CASE REPORT: We describe a white male patient from a nursing home who was reinfected with severe acute respiratory syndrome coronavirus 2 with severe disease manifesting as dyspnea, fevers, and encephalopathy with hypoxemic respiratory failure requiring intubation, elevated inflammatory markers, and lung infiltrates on imaging, after initially testing positive with mild symptoms 2 months prior to presentation. Notably, severe acute respiratory syndrome coronavirus 2 antibodies were detected, which indicated this was a coronavirus disease 2019 reinfection. After treatment with remdesivir, dexamethasone, and convalescent plasma, he was subsequently extubated and discharged home after 2 weeks. CONCLUSION: It is not clear whether an initial infection with severe acute respiratory syndrome coronavirus 2 and recovery provides prolonged immunity beyond 2 months. Furthermore, even if antibodies are present, it does not guarantee an attenuated course during reinfection. Therefore, vaccination plays an important role in prevention. Long-term cohort studies will be needed to study the factors behind reinfection. SN - 1752-1947 UR - https://www.unboundmedicine.com/medline/citation/34284812/Severe_reinfection_with_severe_acute_respiratory_syndrome_coronavirus_2_in_a_nursing_home_resident:_a_case_report. L2 - https://jmedicalcasereports.biomedcentral.com/articles/10.1186/s13256-021-02958-4 DB - PRIME DP - Unbound Medicine ER -