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Severe acquired haemophilia associated with asymptomatic SARS-CoV-2 infection.
BMJ Case Rep. 2021 Jul 20; 14(7)BC

Abstract

A 65-year-old man presented with symptoms of severe subcutaneous bleeding in his arm, which led to compartment syndrome requiring fasciotomy and massive blood transfusion protocol. Medical history was significant for history of autoimmune thyroid disease. Workup revealed elevated partial thromboplastin time, decreased factor VIII levels and elevated factor VIII inhibitor levels. He was worked up for causes of acquired haemophilia A and was found to have an elevated SARS-CoV-2 antibody level. Given his negative workup for other secondary aetiologies, we suspect that the cause of his haemophilia A was from his SARS-CoV-2 infection, which has been observed previously in various case reports.

Authors+Show Affiliations

Department of Internal Medicine, NSLIJ Health System, New Hyde Park, New York, USA Kevwangyu@gmail.com.Department of Internal Medicine, NSLIJ Health System, New Hyde Park, New York, USA.Department of Internal Medicine, Northwell Health, New Hyde Park, New York, USA.Department of Hematology Oncology, Northwell Health, New Hyde Park, New York, USA.

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

34285024

Citation

Wang, Kevin Y., et al. "Severe Acquired Haemophilia Associated With Asymptomatic SARS-CoV-2 Infection." BMJ Case Reports, vol. 14, no. 7, 2021.
Wang KY, Shah P, Roarke DT, et al. Severe acquired haemophilia associated with asymptomatic SARS-CoV-2 infection. BMJ Case Rep. 2021;14(7).
Wang, K. Y., Shah, P., Roarke, D. T., & Shakil, S. A. (2021). Severe acquired haemophilia associated with asymptomatic SARS-CoV-2 infection. BMJ Case Reports, 14(7). https://doi.org/10.1136/bcr-2021-242884
Wang KY, et al. Severe Acquired Haemophilia Associated With Asymptomatic SARS-CoV-2 Infection. BMJ Case Rep. 2021 Jul 20;14(7) PubMed PMID: 34285024.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Severe acquired haemophilia associated with asymptomatic SARS-CoV-2 infection. AU - Wang,Kevin Y, AU - Shah,Pratik, AU - Roarke,Dennis T, AU - Shakil,Shams A, Y1 - 2021/07/20/ PY - 2021/7/21/entrez PY - 2021/7/22/pubmed PY - 2021/7/23/medline KW - COVID-19 KW - Haematology (drugs and medicines) JF - BMJ case reports JO - BMJ Case Rep VL - 14 IS - 7 N2 - A 65-year-old man presented with symptoms of severe subcutaneous bleeding in his arm, which led to compartment syndrome requiring fasciotomy and massive blood transfusion protocol. Medical history was significant for history of autoimmune thyroid disease. Workup revealed elevated partial thromboplastin time, decreased factor VIII levels and elevated factor VIII inhibitor levels. He was worked up for causes of acquired haemophilia A and was found to have an elevated SARS-CoV-2 antibody level. Given his negative workup for other secondary aetiologies, we suspect that the cause of his haemophilia A was from his SARS-CoV-2 infection, which has been observed previously in various case reports. SN - 1757-790X UR - https://www.unboundmedicine.com/medline/citation/34285024/Severe_acquired_haemophilia_associated_with_asymptomatic_SARS-CoV-2_infection. L2 - https://casereports.bmj.com/lookup/pmidlookup?view=long&pmid=34285024 DB - PRIME DP - Unbound Medicine ER -