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Inter-subject variation in ACE2 protein expression in human airway epithelia and its relationship to SARS-CoV-2 infection.
J Infect Dis. 2021 Jul 21 [Online ahead of print]JI

Abstract

SARS-CoV-2 initiates entry into airway epithelia by binding its receptor, ACE2. To explore whether inter-individual variation in ACE2 abundance contributes to variability in COVID-19 outcomes, we measured ACE2 protein abundance in primary airway epithelial cultures derived from 58 human donor lungs. We found no evidence for sex- or age-dependent differences in ACE2 protein expression. Further, we found that variations in ACE2 abundance had minimal effects on viral replication and induction of the interferon response in airway epithelia infected with SARS-CoV-2. Our results highlight the relative importance of additional host factors, beyond viral receptor expression, in determining COVID-19 lung disease outcomes.

Authors+Show Affiliations

Department of Pediatrics, University of Iowa, Iowa City, IA 52242, USA.Department of Pediatrics, University of Iowa, Iowa City, IA 52242, USA.Department of Pediatrics, University of Iowa, Iowa City, IA 52242, USA.Department of Pediatrics and Microbiology and Immunology, University of Iowa, Iowa City, IA, 52242, USA.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

34289058

Citation

Li, Kun, et al. "Inter-subject Variation in ACE2 Protein Expression in Human Airway Epithelia and Its Relationship to SARS-CoV-2 Infection." The Journal of Infectious Diseases, 2021.
Li K, Wohlford-Lenane C, Bartlett JA, et al. Inter-subject variation in ACE2 protein expression in human airway epithelia and its relationship to SARS-CoV-2 infection. J Infect Dis. 2021.
Li, K., Wohlford-Lenane, C., Bartlett, J. A., & McCray, P. B. (2021). Inter-subject variation in ACE2 protein expression in human airway epithelia and its relationship to SARS-CoV-2 infection. The Journal of Infectious Diseases. https://doi.org/10.1093/infdis/jiab383
Li K, et al. Inter-subject Variation in ACE2 Protein Expression in Human Airway Epithelia and Its Relationship to SARS-CoV-2 Infection. J Infect Dis. 2021 Jul 21; PubMed PMID: 34289058.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Inter-subject variation in ACE2 protein expression in human airway epithelia and its relationship to SARS-CoV-2 infection. AU - Li,Kun, AU - Wohlford-Lenane,Christine, AU - Bartlett,Jennifer A, AU - McCray,Paul B, Y1 - 2021/07/21/ PY - 2021/05/18/received PY - 2021/7/21/entrez PY - 2021/7/22/pubmed PY - 2021/7/22/medline KW - ACE2 KW - COVID-19 KW - SARS-CoV-2 KW - airway epithelia KW - risk factors KW - viral receptor abundance JF - The Journal of infectious diseases JO - J Infect Dis N2 - SARS-CoV-2 initiates entry into airway epithelia by binding its receptor, ACE2. To explore whether inter-individual variation in ACE2 abundance contributes to variability in COVID-19 outcomes, we measured ACE2 protein abundance in primary airway epithelial cultures derived from 58 human donor lungs. We found no evidence for sex- or age-dependent differences in ACE2 protein expression. Further, we found that variations in ACE2 abundance had minimal effects on viral replication and induction of the interferon response in airway epithelia infected with SARS-CoV-2. Our results highlight the relative importance of additional host factors, beyond viral receptor expression, in determining COVID-19 lung disease outcomes. SN - 1537-6613 UR - https://www.unboundmedicine.com/medline/citation/34289058/Inter-subject_variation_in_ACE2_protein_expression_in_human_airway_epithelia_and_its_relationship_to_SARS-CoV-2_infection. L2 - https://academic.oup.com/jid/article-lookup/doi/10.1093/infdis/jiab383 DB - PRIME DP - Unbound Medicine ER -
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