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Erythema nodosum-like eruption in coronavirus disease 2019: A case report and literature review of Asian countries.
J Dermatol. 2021 Jul 21 [Online ahead of print]JD

Abstract

In the worldwide coronavirus disease 2019 (COVID-19) outbreak, skin manifestations were seen in COVID-19 patients. We report a case in which a COVID-19 patient developed cutaneous lesions that were diagnosed as erythema nodosum-like lesions, which were associated with COVID-19. Nasopharyngeal swab polymerase chain reaction (PCR) confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Histopathologically, extensive inflammation was seen from the epidermis to the fat tissue. An organized thrombus and disrupted inner elastic lamina were seen in an intradermal vessel. These findings suggest septal panniculitis with cutaneous polyarteritis nodosa. The results of PCR using the specimen of skin lesion was negative. The patient took non-steroidal anti-inflammatory drugs and the skin lesion improved in 3 weeks. To characterize the skin eruption, we reviewed previous reports on COVID-19 (confirmed by the detection of SARS-CoV-2 infection) from Asian countries. The type of eruption and timing of its appearance in this case seemed rare. Differences in skin manifestations between Western and Asian countries were noted.

Authors+Show Affiliations

Department of Dermatology, Gunma University Graduate School of Medicine, Maebashi, Japan.Department of Dermatology, Gunma University Graduate School of Medicine, Maebashi, Japan. Department of Dermatology, Kanazawa Medical University, Kahoku-gun, Japan.Department of Neurology, Gunma University Graduate School of Medicine, Maebashi, Japan.Department of Neurology, Gunma University Graduate School of Medicine, Maebashi, Japan.Department of Neurology, Gunma University Graduate School of Medicine, Maebashi, Japan.Department of Diagnostic Pathology, Gunma University Hospital, Maebashi, Japan.Department of Infection Control and Prevention Center, Gunma University Hospital, Maebashi, Japan.Department of Infection Control and Prevention Center, Gunma University Hospital, Maebashi, Japan.Gunma Prefectural Institute of Public Health and Environmental Sciences, Maebashi, Japan.Department of Dermatology, Gunma University Graduate School of Medicine, Maebashi, Japan.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

34289146

Citation

Kuriyama, Yuko, et al. "Erythema Nodosum-like Eruption in Coronavirus Disease 2019: a Case Report and Literature Review of Asian Countries." The Journal of Dermatology, 2021.
Kuriyama Y, Shimizu A, Oka H, et al. Erythema nodosum-like eruption in coronavirus disease 2019: A case report and literature review of Asian countries. J Dermatol. 2021.
Kuriyama, Y., Shimizu, A., Oka, H., Sato, M., Makioka, K., Ikota, H., Yanagisawa, K., Tokue, Y., Tsukagoshi, H., & Motegi, S. I. (2021). Erythema nodosum-like eruption in coronavirus disease 2019: A case report and literature review of Asian countries. The Journal of Dermatology. https://doi.org/10.1111/1346-8138.16071
Kuriyama Y, et al. Erythema Nodosum-like Eruption in Coronavirus Disease 2019: a Case Report and Literature Review of Asian Countries. J Dermatol. 2021 Jul 21; PubMed PMID: 34289146.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Erythema nodosum-like eruption in coronavirus disease 2019: A case report and literature review of Asian countries. AU - Kuriyama,Yuko, AU - Shimizu,Akira, AU - Oka,Hironori, AU - Sato,Masayuki, AU - Makioka,Koki, AU - Ikota,Hayato, AU - Yanagisawa,Kunio, AU - Tokue,Yutaka, AU - Tsukagoshi,Hiroyuki, AU - Motegi,Sei-Ichiro, Y1 - 2021/07/21/ PY - 2021/05/03/received PY - 2021/07/03/accepted PY - 2021/7/21/entrez PY - 2021/7/22/pubmed PY - 2021/7/22/medline KW - coronavirus disease 2019 KW - erythema nodosum KW - race KW - severe acute respiratory syndrome coronavirus 2 KW - thrombosis JF - The Journal of dermatology JO - J Dermatol N2 - In the worldwide coronavirus disease 2019 (COVID-19) outbreak, skin manifestations were seen in COVID-19 patients. We report a case in which a COVID-19 patient developed cutaneous lesions that were diagnosed as erythema nodosum-like lesions, which were associated with COVID-19. Nasopharyngeal swab polymerase chain reaction (PCR) confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Histopathologically, extensive inflammation was seen from the epidermis to the fat tissue. An organized thrombus and disrupted inner elastic lamina were seen in an intradermal vessel. These findings suggest septal panniculitis with cutaneous polyarteritis nodosa. The results of PCR using the specimen of skin lesion was negative. The patient took non-steroidal anti-inflammatory drugs and the skin lesion improved in 3 weeks. To characterize the skin eruption, we reviewed previous reports on COVID-19 (confirmed by the detection of SARS-CoV-2 infection) from Asian countries. The type of eruption and timing of its appearance in this case seemed rare. Differences in skin manifestations between Western and Asian countries were noted. SN - 1346-8138 UR - https://www.unboundmedicine.com/medline/citation/34289146/Erythema_nodosum-like_eruption_in_coronavirus_disease_2019:_A_case_report_and_literature_review_of_Asian_countries. L2 - https://doi.org/10.1111/1346-8138.16071 DB - PRIME DP - Unbound Medicine ER -
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