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Gastrointestinal tissue as a "new" target of pollution exposure.
IUBMB Life. 2021 Jul 21 [Online ahead of print]IL

Abstract

Airborne pollution has become a leading cause of global death in industrialized cities and the exposure to environmental pollutants has been demonstrated to have adverse effects on human health. Among the pollutants, particulate matter (PM) is one of the most toxic and although its exposure has been more commonly correlated with respiratory diseases, gastrointestinal (GI) complications have also been reported as a consequence to PM exposure. Due to its composition, PM is able to exert on intestinal mucosa both direct damaging effects, (by reaching it either via direct ingestion of contaminated food and water or indirect inhalation and consequent macrophagic mucociliary clearance) and indirect ones via generation of systemic inflammation. The relationship between respiratory and GI conditions is well described by the lung-gut axis and more recently, has become even clearer during coronavirus disease 2019 (COVID-19) pandemic, when respiratory symptoms were associated with gastrointestinal conditions. This review aims at pointing out the mechanisms and the models used to evaluate PM induced GI tract damage.

Authors+Show Affiliations

Department of Animal Science, Plants for Human Health Institute, Kannapolis, North Carolina, USA.Department of Animal Science, Plants for Human Health Institute, Kannapolis, North Carolina, USA.Department of Animal Science, Plants for Human Health Institute, Kannapolis, North Carolina, USA. Department of Neuroscience and Rehabilitation, University of Ferrara, Ferrara, Italy. Department of Food and Nutrition, Kyung Hee University, Seoul, South Korea.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

34289226

Citation

Pambianchi, Erika, et al. "Gastrointestinal Tissue as a "new" Target of Pollution Exposure." IUBMB Life, 2021.
Pambianchi E, Pecorelli A, Valacchi G. Gastrointestinal tissue as a "new" target of pollution exposure. IUBMB Life. 2021.
Pambianchi, E., Pecorelli, A., & Valacchi, G. (2021). Gastrointestinal tissue as a "new" target of pollution exposure. IUBMB Life. https://doi.org/10.1002/iub.2530
Pambianchi E, Pecorelli A, Valacchi G. Gastrointestinal Tissue as a "new" Target of Pollution Exposure. IUBMB Life. 2021 Jul 21; PubMed PMID: 34289226.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gastrointestinal tissue as a "new" target of pollution exposure. AU - Pambianchi,Erika, AU - Pecorelli,Alessandra, AU - Valacchi,Giuseppe, Y1 - 2021/07/21/ PY - 2021/07/01/revised PY - 2021/05/31/received PY - 2021/07/01/accepted PY - 2021/7/21/entrez PY - 2021/7/22/pubmed PY - 2021/7/22/medline KW - 4HNE KW - COVID19 KW - oxidative damage KW - particulate matters JF - IUBMB life JO - IUBMB Life N2 - Airborne pollution has become a leading cause of global death in industrialized cities and the exposure to environmental pollutants has been demonstrated to have adverse effects on human health. Among the pollutants, particulate matter (PM) is one of the most toxic and although its exposure has been more commonly correlated with respiratory diseases, gastrointestinal (GI) complications have also been reported as a consequence to PM exposure. Due to its composition, PM is able to exert on intestinal mucosa both direct damaging effects, (by reaching it either via direct ingestion of contaminated food and water or indirect inhalation and consequent macrophagic mucociliary clearance) and indirect ones via generation of systemic inflammation. The relationship between respiratory and GI conditions is well described by the lung-gut axis and more recently, has become even clearer during coronavirus disease 2019 (COVID-19) pandemic, when respiratory symptoms were associated with gastrointestinal conditions. This review aims at pointing out the mechanisms and the models used to evaluate PM induced GI tract damage. SN - 1521-6551 UR - https://www.unboundmedicine.com/medline/citation/34289226/Gastrointestinal_tissue_as_a_"new"_target_of_pollution_exposure. L2 - https://doi.org/10.1002/iub.2530 DB - PRIME DP - Unbound Medicine ER -
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