Tags

Type your tag names separated by a space and hit enter

Anterior uveitis onset after bnt162b2 vaccination: is this just a coincidence?
Int J Infect Dis. 2021 Jul 18; 110:95-97.IJ

Abstract

BACKGROUND

Uveitis is a vision-threatening inflammation and is considered an ophthalmic emergency. It generally arises as a result of autoimmune conditions, infections, or ocular trauma, but it may also occur as an isolated disorder. Over the past decades, several cases of vaccine-associated uveitis have been described, with the hepatitis B virus vaccine being the leading cause.

CLINICAL CASE

A case of anterior uveitis in a 23-year-old male, with onset 14 days after the second dose of BNT162b2 COVID-19 vaccine, is reported here. Initial symptoms were pain, photophobia, and red eye. Ocular examination showed pericheratic and conjunctival hyperaemia, posterior synechiae, and anterior chamber cells ± keratic precipitates in the lower quadrants. The posterior segment did not show any alteration, and optical coherence tomography ruled out the presence of cystoid macular oedema. After a 10-day treatment course of topical steroids and cycloplegic eye drops, the ocular inflammatory signs disappeared and visual acuity was completely restored. Even if causality remains presumed, a warning should be given to physicians about the possibility of eye inflammation following SARS-CoV-2 vaccination.

Authors+Show Affiliations

Infectious Diseases Unit, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, Italy.Infectious Diseases Unit, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, Italy; Department of Pathophysiology and Transplantation, University of Milano, Milano, Italy. Electronic address: andrea.lombardi@unimi.it.Istituto Clinico Villa Aprica, Como, Italy.Department of Biomedical and Clinical Science "Luigi Sacco", Eye Clinic, Luigi Sacco Hospital, University of Milan, Milan, Italy; Save Sight Institute, University of Sydney, Sydney, New South Wales, Australia.Infectious Diseases Unit, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, Italy; Department of Pathophysiology and Transplantation, University of Milano, Milano, Italy; Centre for Multidisciplinary Research in Health Science (MACH), University of Milano, Milano, Italy.Infectious Diseases Unit, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, Italy; Department of Pathophysiology and Transplantation, University of Milano, Milano, Italy; Centre for Multidisciplinary Research in Health Science (MACH), University of Milano, Milano, Italy.

Pub Type(s)

Case Reports

Language

eng

PubMed ID

34289406

Citation

Renisi, Giulia, et al. "Anterior Uveitis Onset After Bnt162b2 Vaccination: Is This Just a Coincidence?" International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases, vol. 110, 2021, pp. 95-97.
Renisi G, Lombardi A, Stanzione M, et al. Anterior uveitis onset after bnt162b2 vaccination: is this just a coincidence? Int J Infect Dis. 2021;110:95-97.
Renisi, G., Lombardi, A., Stanzione, M., Invernizzi, A., Bandera, A., & Gori, A. (2021). Anterior uveitis onset after bnt162b2 vaccination: is this just a coincidence? International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases, 110, 95-97. https://doi.org/10.1016/j.ijid.2021.07.035
Renisi G, et al. Anterior Uveitis Onset After Bnt162b2 Vaccination: Is This Just a Coincidence. Int J Infect Dis. 2021 Jul 18;110:95-97. PubMed PMID: 34289406.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anterior uveitis onset after bnt162b2 vaccination: is this just a coincidence? AU - Renisi,Giulia, AU - Lombardi,Andrea, AU - Stanzione,Massimo, AU - Invernizzi,Alessandro, AU - Bandera,Alessandra, AU - Gori,Andrea, Y1 - 2021/07/18/ PY - 2021/06/01/received PY - 2021/07/13/revised PY - 2021/07/14/accepted PY - 2021/7/22/pubmed PY - 2021/7/22/medline PY - 2021/7/21/entrez KW - Adverse event KW - BNT162b2 vaccine KW - SARS-CoV-2 KW - Uveitis SP - 95 EP - 97 JF - International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases JO - Int J Infect Dis VL - 110 N2 - BACKGROUND: Uveitis is a vision-threatening inflammation and is considered an ophthalmic emergency. It generally arises as a result of autoimmune conditions, infections, or ocular trauma, but it may also occur as an isolated disorder. Over the past decades, several cases of vaccine-associated uveitis have been described, with the hepatitis B virus vaccine being the leading cause. CLINICAL CASE: A case of anterior uveitis in a 23-year-old male, with onset 14 days after the second dose of BNT162b2 COVID-19 vaccine, is reported here. Initial symptoms were pain, photophobia, and red eye. Ocular examination showed pericheratic and conjunctival hyperaemia, posterior synechiae, and anterior chamber cells ± keratic precipitates in the lower quadrants. The posterior segment did not show any alteration, and optical coherence tomography ruled out the presence of cystoid macular oedema. After a 10-day treatment course of topical steroids and cycloplegic eye drops, the ocular inflammatory signs disappeared and visual acuity was completely restored. Even if causality remains presumed, a warning should be given to physicians about the possibility of eye inflammation following SARS-CoV-2 vaccination. SN - 1878-3511 UR - https://www.unboundmedicine.com/medline/citation/34289406/ANTERIOR_UVEITIS_ONSET_AFTER_BNT162b2_VACCINATION:_IS_THIS_JUST_A_COINCIDENCE L2 - https://linkinghub.elsevier.com/retrieve/pii/S1201-9712(21)00591-9 DB - PRIME DP - Unbound Medicine ER -
Try the Free App:
Prime PubMed app for iOS iPhone iPad
Prime PubMed app for Android
Prime PubMed is provided
free to individuals by:
Unbound Medicine.