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Re-infection with a different SARS-CoV-2 clade and prolonged viral shedding in a hematopoietic stem cell transplantation patient.
Int J Infect Dis. 2021 Sep; 110:267-271.IJ

Abstract

Immunocompromised patients who have a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection pose many clinical and public health challenges. We describe the case of a hematopoietic stem cell transplantation patient with lymphoma who had a protracted illness requiring three consecutive hospital admissions. Whole genome sequencing confirmed two different SARS-CoV-2 clades. Clinical management issues and the unanswered questions arising from this case are discussed.

Authors+Show Affiliations

Department of Medicine, King Faisal Specialist Hospital and Research Center, Jeddah, Saudi Arabia.Special Infectious Agents Unit-BSL3, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia; Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia.Department of Pathology and Laboratory Medicine, King Faisal Specialist Hospital and Research Center, Jeddah, Saudi Arabia.Special Infectious Agents Unit-BSL3, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia; Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia.Department of Medicine, King Faisal Specialist Hospital and Research Center, Jeddah, Saudi Arabia.Department of Medicine, King Faisal Specialist Hospital and Research Center, Jeddah, Saudi Arabia.Department of Medicine, King Faisal Specialist Hospital and Research Center, Jeddah, Saudi Arabia; Department of Internal Medicine, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.Adult Hematology and Bone Marrow Transplant Section, Oncology Department, King Faisal Specialist Hospital and Research Center, Jeddah, Saudi Arabia.Department of Medicine, College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia.Computational Bioscience Research Centre, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia.Computational Bioscience Research Centre, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia.Computational Bioscience Research Centre, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia.Special Infectious Agents Unit-BSL3, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia; Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia.Special Infectious Agents Unit-BSL3, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia.Special Infectious Agents Unit-BSL3, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia.Special Infectious Agents Unit-BSL3, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia.Special Infectious Agents Unit-BSL3, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia.Infectious Disease Unit, Specialty Internal Medicine, Johns Hopkins Aramco Healthcare, Dhahran, Saudi Arabia; Infectious Disease Division, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA; Infectious Disease Division, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.Division of Infection and Immunity, Centre for Clinical Microbiology, University College London Royal Free Campus, London, UK; NIHR Biomedical Research Centre, UCL Hospitals NHS Foundation Trust, London, UK.Special Infectious Agents Unit-BSL3, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia; Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia. Electronic address: eazhar@kau.edu.sa.

Pub Type(s)

Case Reports

Language

eng

PubMed ID

34289407

Citation

Alshukairi, Abeer N., et al. "Re-infection With a Different SARS-CoV-2 Clade and Prolonged Viral Shedding in a Hematopoietic Stem Cell Transplantation Patient." International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases, vol. 110, 2021, pp. 267-271.
Alshukairi AN, El-Kafrawy SA, Dada A, et al. Re-infection with a different SARS-CoV-2 clade and prolonged viral shedding in a hematopoietic stem cell transplantation patient. Int J Infect Dis. 2021;110:267-271.
Alshukairi, A. N., El-Kafrawy, S. A., Dada, A., Yasir, M., Yamani, A. H., Saeedi, M. F., Aljohaney, A., AlJohani, N. I., Bahaudden, H. A., Alam, I., Gojobori, T., Radovanovic, A., Alandijany, T. A., Othman, N. A., Alsubhi, T. L., Hassan, A. M., Tolah, A. M., Al-Tawfiq, J. A., Zumla, A., & Azhar, E. I. (2021). Re-infection with a different SARS-CoV-2 clade and prolonged viral shedding in a hematopoietic stem cell transplantation patient. International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases, 110, 267-271. https://doi.org/10.1016/j.ijid.2021.07.036
Alshukairi AN, et al. Re-infection With a Different SARS-CoV-2 Clade and Prolonged Viral Shedding in a Hematopoietic Stem Cell Transplantation Patient. Int J Infect Dis. 2021;110:267-271. PubMed PMID: 34289407.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Re-infection with a different SARS-CoV-2 clade and prolonged viral shedding in a hematopoietic stem cell transplantation patient. AU - Alshukairi,Abeer N, AU - El-Kafrawy,Sherif A, AU - Dada,Ashraf, AU - Yasir,Muhammad, AU - Yamani,Amani H, AU - Saeedi,Mohammed F, AU - Aljohaney,Ahmed, AU - AlJohani,Naif I, AU - Bahaudden,Husam A, AU - Alam,Intikhab, AU - Gojobori,Takashi, AU - Radovanovic,Aleksandar, AU - Alandijany,Thamir A, AU - Othman,Norah A, AU - Alsubhi,Tagreed L, AU - Hassan,Ahmed M, AU - Tolah,Ahmed M, AU - Al-Tawfiq,Jaffar A, AU - Zumla,Alimuddin, AU - Azhar,Esam I, Y1 - 2021/07/18/ PY - 2021/05/22/received PY - 2021/07/12/revised PY - 2021/07/14/accepted PY - 2021/7/22/pubmed PY - 2021/7/22/medline PY - 2021/7/21/entrez KW - COVID-19 KW - Hematological stem cell transplant KW - Immunocompromised KW - Prolonged viral shedding KW - Re-infection KW - SARS-CoV-2 SP - 267 EP - 271 JF - International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases JO - Int J Infect Dis VL - 110 N2 - Immunocompromised patients who have a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection pose many clinical and public health challenges. We describe the case of a hematopoietic stem cell transplantation patient with lymphoma who had a protracted illness requiring three consecutive hospital admissions. Whole genome sequencing confirmed two different SARS-CoV-2 clades. Clinical management issues and the unanswered questions arising from this case are discussed. SN - 1878-3511 UR - https://www.unboundmedicine.com/medline/citation/34289407/Re-infection_with_different_SARS-CoV-2_clade_and_prolonged_viral_shedding_in_a_patient_with_hematopoietic_stem_cell_transplantation:_SARS-CoV-2_Re-infection_with_different_clade. L2 - https://linkinghub.elsevier.com/retrieve/pii/S1201-9712(21)00592-0 DB - PRIME DP - Unbound Medicine ER -