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Clinical characteristics and risk factors for mortality in COVID-19 inpatients in Birjand, Iran: a single-center retrospective study.
Eur J Med Res. 2021 Jul 21; 26(1):79.EJ

Abstract

BACKGROUND

The coronavirus disease 2019(COVID-19) has affected mortality worldwide. The Cox proportional hazard (CPH) model is becoming more popular in time-to-event data analysis. This study aimed to evaluate the clinical characteristics in COVID-19 inpatients including (survivor and non-survivor); thus helping clinicians give the right treatment and assess prognosis and guide the treatment.

METHODS

This single-center study was conducted at Hospital for COVID-19 patients in Birjand. Inpatients with confirmed COVID-19 were included. Patients were classified as the discharged or survivor group and the death or non-survivor group based on their outcome (improvement or death). Clinical, epidemiological characteristics, as well as laboratory parameters, were extracted from electronic medical records. Independent sample T test and the Chi-square test or Fisher's exact test were used to evaluate the association of interested variables. The CPH model was used for survival analysis in the COVID-19 death patients. Significant level was set as 0.05 in all analyses.

RESULTS

The results showed that the mortality rate was about (17.4%). So that, 62(17%) patients had died due to COVID-19, and 298 (83.6%) patients had recovered and discharged. Clinical parameters and comorbidities such as oxygen saturation, lymphocyte and platelet counts, hemoglobin levels, C-reactive protein, and liver and kidney function, were statistically significant between both studied groups. The results of the CPH model showed that comorbidities, hypertension, lymphocyte counts, platelet count, and C-reactive protein level, may increase the risk of death due to the COVID-19 as risk factors in inpatients cases.

CONCLUSIONS

Patients with, lower lymphocyte counts in hemogram, platelet count and serum albumin, and high C-reactive protein level, and also patients with comorbidities may have more risk for death. So, it should be given more attention to risk management in the progression of COVID-19 disease.

Authors+Show Affiliations

Department of Biostatistics and Epidemiology, Faculty of Health, Birjand University of Medical Sciences, Birjand, Iran.Department of Biostatistics and Epidemiology, Faculty of Health, Birjand University of Medical Sciences, Birjand, Iran. dr.osmani68@gmail.com. Infectious Disease Research Center, Birjand University of Medical Sciences, Birjand, Iran. dr.osmani68@gmail.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

34289910

Citation

Azarkar, Ghodsiyeh, and Freshteh Osmani. "Clinical Characteristics and Risk Factors for Mortality in COVID-19 Inpatients in Birjand, Iran: a Single-center Retrospective Study." European Journal of Medical Research, vol. 26, no. 1, 2021, p. 79.
Azarkar G, Osmani F. Clinical characteristics and risk factors for mortality in COVID-19 inpatients in Birjand, Iran: a single-center retrospective study. Eur J Med Res. 2021;26(1):79.
Azarkar, G., & Osmani, F. (2021). Clinical characteristics and risk factors for mortality in COVID-19 inpatients in Birjand, Iran: a single-center retrospective study. European Journal of Medical Research, 26(1), 79. https://doi.org/10.1186/s40001-021-00553-3
Azarkar G, Osmani F. Clinical Characteristics and Risk Factors for Mortality in COVID-19 Inpatients in Birjand, Iran: a Single-center Retrospective Study. Eur J Med Res. 2021 Jul 21;26(1):79. PubMed PMID: 34289910.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical characteristics and risk factors for mortality in COVID-19 inpatients in Birjand, Iran: a single-center retrospective study. AU - Azarkar,Ghodsiyeh, AU - Osmani,Freshteh, Y1 - 2021/07/21/ PY - 2021/05/11/received PY - 2021/07/13/accepted PY - 2021/7/22/entrez PY - 2021/7/23/pubmed PY - 2021/7/29/medline KW - COVID-19 KW - Cox model KW - Risk factors of death KW - Survival model SP - 79 EP - 79 JF - European journal of medical research JO - Eur J Med Res VL - 26 IS - 1 N2 - BACKGROUND: The coronavirus disease 2019(COVID-19) has affected mortality worldwide. The Cox proportional hazard (CPH) model is becoming more popular in time-to-event data analysis. This study aimed to evaluate the clinical characteristics in COVID-19 inpatients including (survivor and non-survivor); thus helping clinicians give the right treatment and assess prognosis and guide the treatment. METHODS: This single-center study was conducted at Hospital for COVID-19 patients in Birjand. Inpatients with confirmed COVID-19 were included. Patients were classified as the discharged or survivor group and the death or non-survivor group based on their outcome (improvement or death). Clinical, epidemiological characteristics, as well as laboratory parameters, were extracted from electronic medical records. Independent sample T test and the Chi-square test or Fisher's exact test were used to evaluate the association of interested variables. The CPH model was used for survival analysis in the COVID-19 death patients. Significant level was set as 0.05 in all analyses. RESULTS: The results showed that the mortality rate was about (17.4%). So that, 62(17%) patients had died due to COVID-19, and 298 (83.6%) patients had recovered and discharged. Clinical parameters and comorbidities such as oxygen saturation, lymphocyte and platelet counts, hemoglobin levels, C-reactive protein, and liver and kidney function, were statistically significant between both studied groups. The results of the CPH model showed that comorbidities, hypertension, lymphocyte counts, platelet count, and C-reactive protein level, may increase the risk of death due to the COVID-19 as risk factors in inpatients cases. CONCLUSIONS: Patients with, lower lymphocyte counts in hemogram, platelet count and serum albumin, and high C-reactive protein level, and also patients with comorbidities may have more risk for death. So, it should be given more attention to risk management in the progression of COVID-19 disease. SN - 2047-783X UR - https://www.unboundmedicine.com/medline/citation/34289910/Clinical_characteristics_and_risk_factors_for_mortality_in_COVID-19_inpatients_in_Birjand,_Iran:_a_single-center_retrospective_study. L2 - https://eurjmedres.biomedcentral.com/articles/10.1186/s40001-021-00553-3 DB - PRIME DP - Unbound Medicine ER -