Tags

Type your tag names separated by a space and hit enter

Glycan Nanostructures of Human Coronaviruses.
Int J Nanomedicine. 2021; 16:4813-4830.IJ

Abstract

Human coronaviruses present a substantial global disease burden, causing damage to populations' health, economy, and social well-being. Glycans are one of the main structural components of all microbes and organismic structures, including viruses-playing multiple essential roles in virus infection and immunity. Studying and understanding virus glycans at the nanoscale provide new insights into the diagnosis and treatment of viruses. Glycan nanostructures are considered potential targets for molecular diagnosis, antiviral therapeutics, and the development of vaccines. This review article describes glycan nanostructures (eg, glycoproteins and glycolipids) that exist in cells, subcellular structures, and microbes. We detail the structure, characterization, synthesis, and functions of virus glycans. Furthermore, we describe the glycan nanostructures of different human coronaviruses, such as human coronavirus 229E (HCoV-229E), human coronavirus OC43 (HCoV-OC43), severe acute respiratory syndrome-associated coronavirus (SARS-CoV), human coronavirus NL63 (HCoV-NL63), human coronavirus HKU1 (HCoV-HKU1), the Middle East respiratory syndrome-associated coronavirus (MERS-CoV), and how glycan nanotechnology can be useful to prevent and combat human coronaviruses infections, along with possibilities that are not yet explored.

Authors+Show Affiliations

State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, People's Republic of China.Department of Pathology and Molecular Pathology, University of Zurich and University Hospital Zurich, Zurich, Switzerland.Division of Gastroenterology and Liver Diseases, Case Western Reserve University School of Medicine, Cleveland, OH, USA. Digestive Health Research Institute, Case Western Reserve University, Cleveland, OH, USA. Germ-Free and Gut Microbiome Core, Cleveland Digestive Diseases Research Core Center, Case Western Reserve University, Cleveland, OH, USA. University Hospitals Research and Education Institute, University Hospital Cleveland Medical Center, Cleveland, OH, USA.Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH, USA.State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, People's Republic of China.Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH, USA.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

34290504

Citation

Guo, Wanru, et al. "Glycan Nanostructures of Human Coronaviruses." International Journal of Nanomedicine, vol. 16, 2021, pp. 4813-4830.
Guo W, Lakshminarayanan H, Rodriguez-Palacios A, et al. Glycan Nanostructures of Human Coronaviruses. Int J Nanomedicine. 2021;16:4813-4830.
Guo, W., Lakshminarayanan, H., Rodriguez-Palacios, A., Salata, R. A., Xu, K., & Draz, M. S. (2021). Glycan Nanostructures of Human Coronaviruses. International Journal of Nanomedicine, 16, 4813-4830. https://doi.org/10.2147/IJN.S302516
Guo W, et al. Glycan Nanostructures of Human Coronaviruses. Int J Nanomedicine. 2021;16:4813-4830. PubMed PMID: 34290504.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Glycan Nanostructures of Human Coronaviruses. AU - Guo,Wanru, AU - Lakshminarayanan,Harini, AU - Rodriguez-Palacios,Alex, AU - Salata,Robert A, AU - Xu,Kaijin, AU - Draz,Mohamed S, Y1 - 2021/07/15/ PY - 2021/01/20/received PY - 2021/05/22/accepted PY - 2021/7/22/entrez PY - 2021/7/23/pubmed PY - 2021/9/15/medline KW - SARS-CoV-2 KW - coronaviruses KW - diagnostics KW - glycan KW - glycolipids KW - glycoproteins KW - nanotechnology KW - vaccine SP - 4813 EP - 4830 JF - International journal of nanomedicine JO - Int J Nanomedicine VL - 16 N2 - Human coronaviruses present a substantial global disease burden, causing damage to populations' health, economy, and social well-being. Glycans are one of the main structural components of all microbes and organismic structures, including viruses-playing multiple essential roles in virus infection and immunity. Studying and understanding virus glycans at the nanoscale provide new insights into the diagnosis and treatment of viruses. Glycan nanostructures are considered potential targets for molecular diagnosis, antiviral therapeutics, and the development of vaccines. This review article describes glycan nanostructures (eg, glycoproteins and glycolipids) that exist in cells, subcellular structures, and microbes. We detail the structure, characterization, synthesis, and functions of virus glycans. Furthermore, we describe the glycan nanostructures of different human coronaviruses, such as human coronavirus 229E (HCoV-229E), human coronavirus OC43 (HCoV-OC43), severe acute respiratory syndrome-associated coronavirus (SARS-CoV), human coronavirus NL63 (HCoV-NL63), human coronavirus HKU1 (HCoV-HKU1), the Middle East respiratory syndrome-associated coronavirus (MERS-CoV), and how glycan nanotechnology can be useful to prevent and combat human coronaviruses infections, along with possibilities that are not yet explored. SN - 1178-2013 UR - https://www.unboundmedicine.com/medline/citation/34290504/Glycan_Nanostructures_of_Human_Coronaviruses. L2 - https://dx.doi.org/10.2147/IJN.S302516 DB - PRIME DP - Unbound Medicine ER -