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How is the iceberg of COVID-19? Results from a rapid literature review.
Med J Islam Repub Iran. 2021; 35:77.MJ

Abstract

Background: Given the various reports of the clinical spectrum of the disease, the aim of the present study was to determine possible scenarios of Coronavirus 2019 (COVID-19) iceberg using published articles. Methods: The present study was a rapid review of all international databases, including PubMed (Medline), Scopus, Web of Sciences, Embase, and Cochrane Library from January 1 to October 30, 2020. Results: In this review, 7 scenarios were considered for COVID-19 iceberg, in which the range of fatality percentage was estimated to be 0.5% to 7%, the range of asymptomatic cases 1% to 88.6%, the range of cases with mild symptoms 8% to 78%, no symptoms 1 % to 90 %, the range of intensive care unit (ICU) admission was 0.5% to 14.2%, and finally the intubation percentage was estimated to be 0.2% to 12.2%. The Scenarios Diamond Princess Cruise Ship and Iceland are closer to the reality of the clinical spectrum of COVID-19 around the world, which represent 0.6% and 0.5% of deaths, 0.7% and 1% of intubations, 2.5% and 9.7% of ICU admissions, 1.1% and 6% of hospitalizations, 15% and 31% of cases with mild symptoms, and finally 56.9% and 75% of asymptomatic cases of COVID-19, respectively, which should now be considered as the basis of the clinical knowledge of the disease. Conclusion: Understanding the clinical spectrum and natural knowledge of the disease and paying attention to asymptomatic or mild-symptom cases can help to make better decisions and develop more effective interventions to control COVID-19.

Authors+Show Affiliations

Social Determinants of Health Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran. Department of Epidemiology and Biostatistics, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran.Department of Epidemiology, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.Social Determinants of Health Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran.Urology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Social Determinants of Health Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran. Department of Epidemiology and Biostatistics, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

34291001

Citation

Moradi, Ghobad, et al. "How Is the Iceberg of COVID-19? Results From a Rapid Literature Review." Medical Journal of the Islamic Republic of Iran, vol. 35, 2021, p. 77.
Moradi G, Gholami F, Rasouli MA, et al. How is the iceberg of COVID-19? Results from a rapid literature review. Med J Islam Repub Iran. 2021;35:77.
Moradi, G., Gholami, F., Rasouli, M. A., Bagheri Amiri, F., & Moradi, Y. (2021). How is the iceberg of COVID-19? Results from a rapid literature review. Medical Journal of the Islamic Republic of Iran, 35, 77. https://doi.org/10.47176/mjiri.35.77
Moradi G, et al. How Is the Iceberg of COVID-19? Results From a Rapid Literature Review. Med J Islam Repub Iran. 2021;35:77. PubMed PMID: 34291001.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - How is the iceberg of COVID-19? Results from a rapid literature review. AU - Moradi,Ghobad, AU - Gholami,Fatemeh, AU - Rasouli,Mohammad Aziz, AU - Bagheri Amiri,Fahimeh, AU - Moradi,Yousef, Y1 - 2021/06/16/ PY - 2020/12/15/received PY - 2021/7/22/entrez PY - 2021/7/23/pubmed PY - 2021/7/23/medline KW - Best Estimates KW - COVID 19 KW - Clinical Spectrum KW - Iceberg KW - Natural Knowledge KW - Rapid Review SP - 77 EP - 77 JF - Medical journal of the Islamic Republic of Iran JO - Med J Islam Repub Iran VL - 35 N2 - Background: Given the various reports of the clinical spectrum of the disease, the aim of the present study was to determine possible scenarios of Coronavirus 2019 (COVID-19) iceberg using published articles. Methods: The present study was a rapid review of all international databases, including PubMed (Medline), Scopus, Web of Sciences, Embase, and Cochrane Library from January 1 to October 30, 2020. Results: In this review, 7 scenarios were considered for COVID-19 iceberg, in which the range of fatality percentage was estimated to be 0.5% to 7%, the range of asymptomatic cases 1% to 88.6%, the range of cases with mild symptoms 8% to 78%, no symptoms 1 % to 90 %, the range of intensive care unit (ICU) admission was 0.5% to 14.2%, and finally the intubation percentage was estimated to be 0.2% to 12.2%. The Scenarios Diamond Princess Cruise Ship and Iceland are closer to the reality of the clinical spectrum of COVID-19 around the world, which represent 0.6% and 0.5% of deaths, 0.7% and 1% of intubations, 2.5% and 9.7% of ICU admissions, 1.1% and 6% of hospitalizations, 15% and 31% of cases with mild symptoms, and finally 56.9% and 75% of asymptomatic cases of COVID-19, respectively, which should now be considered as the basis of the clinical knowledge of the disease. Conclusion: Understanding the clinical spectrum and natural knowledge of the disease and paying attention to asymptomatic or mild-symptom cases can help to make better decisions and develop more effective interventions to control COVID-19. SN - 1016-1430 UR - https://www.unboundmedicine.com/medline/citation/34291001/How_is_the_iceberg_of_COVID-19_Results_from_a_rapid_literature_review. L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/34291001/ DB - PRIME DP - Unbound Medicine ER -
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