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Pneumonia Caused by Severe Acute Respiratory Syndrome Coronavirus 2 and Influenza Virus: A Multicenter Comparative Study.
Open Forum Infect Dis. 2021 Jul; 8(7):ofab282.OF

Abstract

Background

Detailed differences in clinical information between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia (CP), which is the main phenotype of SARS-CoV-2 disease, and influenza pneumonia (IP) are still unclear.

Methods

A prospective, multicenter cohort study was conducted by including patients with CP who were hospitalized between January and June 2020 and a retrospective cohort of patients with IP hospitalized from 2009 to 2020. We compared the clinical presentations and studied the prognostic factors of CP and IP.

Results

Compared with the IP group (n = 66), in the multivariate analysis, the CP group (n = 362) had a lower percentage of patients with underlying asthma or chronic obstructive pulmonary disease (P < .01), lower neutrophil-to-lymphocyte ratio (P < .01), lower systolic blood pressure (P < .01), higher diastolic blood pressure (P < .01), lower aspartate aminotransferase level (P < .05), higher serum sodium level (P < .05), and more frequent multilobar infiltrates (P < .05). The diagnostic scoring system based on these findings showed excellent differentiation between CP and IP (area under the receiver operating characteristic curve, 0.889). Moreover, the prognostic predictors were different between CP and IP.

Conclusions

Comprehensive differences between CP and IP were revealed, highlighting the need for early differentiation between these 2 pneumonias in clinical settings.

Authors+Show Affiliations

Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan. Department of Internal Medicine, Sugita Genpaku Memorial Obama Municipal Hospital, Obama, Japan.Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan. Department of Internal Medicine, Sugita Genpaku Memorial Obama Municipal Hospital, Obama, Japan.Department of Respiratory Medicine, Hyogo Prefectural Amagasaki General Medical Center, Amagasaki, Japan.Department of Respiratory Medicine, Hyogo Prefectural Amagasaki General Medical Center, Amagasaki, Japan.Department of Respiratory Medicine, Kyoto City Hospital, Kyoto, Japan.Department of Respiratory Medicine, Fukui Prefectural Hospital, Fukui, Japan.Department of Respiratory Medicine, Fukui Prefectural Hospital, Fukui, Japan.Department of Respiratory Medicine, Kobe City Medical Center General Hospital, Kobe, Japan.Department of Respiratory Medicine, Kobe City Medical Center General Hospital, Kobe, Japan.Department of Respiratory Medicine, Shinko Hospital, Kobe, Japan.Department of Respiratory Medicine, Japanese Red Cross Fukui Hospital, Fukui, Japan.Department of Respiratory Medicine, Japanese Red Cross Fukui Hospital, Fukui, Japan.Department of Respiratory Medicine, Japan Red Cross Wakayama Medical Center, Wakayama, Japan.Respiratory Disease Center, Kitano Hospital, Tazuke Kofukai Medical Research Institute, Osaka, Japan.Respiratory Disease Center, Kitano Hospital, Tazuke Kofukai Medical Research Institute, Osaka, Japan.Department of Respiratory Medicine, Osaka Saiseikai Nakatsu Hospital, Osaka, Japan.Department of Respiratory Medicine, Kishiwada City Hospital, Kishiwaada, Japan.Department of Internal Medicine, Horikawa Hospital, Kyoto, Japan.Division of Respiratory Medicine, Center for Respiratory Disease, National Hospital Organization Kyoto Medical Center, Kyoto, Japan.Department of Respiratory Medicine, Ohara Healthcare Foundation, Kurashiki Central Hospital, Kurashiki, Japan.Department of Respiratory Medicine, Ohara Healthcare Foundation, Kurashiki Central Hospital, Kurashiki, Japan.Department of Respiratory Medicine, Takatsuki Red Cross Hospital, Takatsuki, Japan.Department of Respiratory Medicine, Tenri Hospital, Tenri, Japan.Department of Respiratory Medicine, Rakuwakai Otowa Hospital, Kyoto, Japan.Department of Respiratory Medicine, Kobe City Medical Center West Hospital, Kobe, Japan.Department of Respiratory Medicine, Shizuoka City Shizuoka Hospital, Shizuoka, Japan.Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan. Respiratory Medicine and General Practice, Terada Clinic, Himeji, Japan.Department of Respiratory Medicine, Toyooka Hospital, Toyooka, Japan.Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan. Department of Internal Medicine, Sugita Genpaku Memorial Obama Municipal Hospital, Obama, Japan.Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan. Department of Respiratory Medicine, Osaka Saiseikai Nakatsu Hospital, Osaka, Japan.Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan. Respiratory Disease Center, Kitano Hospital, Tazuke Kofukai Medical Research Institute, Osaka, Japan.Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan. Department of Respiratory Medicine, Kishiwada City Hospital, Kishiwaada, Japan.Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan. Department of Respiratory Medicine, Kishiwada City Hospital, Kishiwaada, Japan.Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan. Department of Respiratory Medicine, Rakuwakai Otowa Hospital, Kyoto, Japan.Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan. Department of Respiratory Medicine, Toyooka Hospital, Toyooka, Japan.Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

34291119

Citation

Oi, Issei, et al. "Pneumonia Caused By Severe Acute Respiratory Syndrome Coronavirus 2 and Influenza Virus: a Multicenter Comparative Study." Open Forum Infectious Diseases, vol. 8, no. 7, 2021, pp. ofab282.
Oi I, Ito I, Hirabayashi M, et al. Pneumonia Caused by Severe Acute Respiratory Syndrome Coronavirus 2 and Influenza Virus: A Multicenter Comparative Study. Open Forum Infect Dis. 2021;8(7):ofab282.
Oi, I., Ito, I., Hirabayashi, M., Endo, K., Emura, M., Kojima, T., Tsukao, H., Tomii, K., Nakagawa, A., Otsuka, K., Akai, M., Oi, M., Sugita, T., Fukui, M., Inoue, D., Hasegawa, Y., Takahashi, K., Yasui, H., Fujita, K., ... Hirai, T. (2021). Pneumonia Caused by Severe Acute Respiratory Syndrome Coronavirus 2 and Influenza Virus: A Multicenter Comparative Study. Open Forum Infectious Diseases, 8(7), ofab282. https://doi.org/10.1093/ofid/ofab282
Oi I, et al. Pneumonia Caused By Severe Acute Respiratory Syndrome Coronavirus 2 and Influenza Virus: a Multicenter Comparative Study. Open Forum Infect Dis. 2021;8(7):ofab282. PubMed PMID: 34291119.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pneumonia Caused by Severe Acute Respiratory Syndrome Coronavirus 2 and Influenza Virus: A Multicenter Comparative Study. AU - Oi,Issei, AU - Ito,Isao, AU - Hirabayashi,Masataka, AU - Endo,Kazuo, AU - Emura,Masahito, AU - Kojima,Toru, AU - Tsukao,Hitokazu, AU - Tomii,Keisuke, AU - Nakagawa,Atsushi, AU - Otsuka,Kojiro, AU - Akai,Masaya, AU - Oi,Masahiro, AU - Sugita,Takakazu, AU - Fukui,Motonari, AU - Inoue,Daiki, AU - Hasegawa,Yoshinori, AU - Takahashi,Kenichi, AU - Yasui,Hiroaki, AU - Fujita,Kohei, AU - Ishida,Tadashi, AU - Ito,Akihiro, AU - Kita,Hideo, AU - Kaji,Yusuke, AU - Tsuchiya,Michiko, AU - Tomioka,Hiromi, AU - Yamada,Takashi, AU - Terada,Satoru, AU - Nakaji,Hitoshi, AU - Hamao,Nobuyoshi, AU - Shirata,Masahiro, AU - Nishioka,Kensuke, AU - Yamazoe,Masatoshi, AU - Shiraishi,Yusuke, AU - Ogimoto,Tatsuya, AU - Hosoya,Kazutaka, AU - Ajimizu,Hitomi, AU - Shima,Hiroshi, AU - Matsumoto,Hisako, AU - Tanabe,Naoya, AU - Hirai,Toyohiro, Y1 - 2021/05/29/ PY - 2021/02/17/received PY - 2021/05/28/accepted PY - 2021/7/22/entrez PY - 2021/7/23/pubmed PY - 2021/7/23/medline KW - COVID-19 KW - influenza KW - multicenter study KW - pneumonia SP - ofab282 EP - ofab282 JF - Open forum infectious diseases JO - Open Forum Infect Dis VL - 8 IS - 7 N2 - Background: Detailed differences in clinical information between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia (CP), which is the main phenotype of SARS-CoV-2 disease, and influenza pneumonia (IP) are still unclear. Methods: A prospective, multicenter cohort study was conducted by including patients with CP who were hospitalized between January and June 2020 and a retrospective cohort of patients with IP hospitalized from 2009 to 2020. We compared the clinical presentations and studied the prognostic factors of CP and IP. Results: Compared with the IP group (n = 66), in the multivariate analysis, the CP group (n = 362) had a lower percentage of patients with underlying asthma or chronic obstructive pulmonary disease (P < .01), lower neutrophil-to-lymphocyte ratio (P < .01), lower systolic blood pressure (P < .01), higher diastolic blood pressure (P < .01), lower aspartate aminotransferase level (P < .05), higher serum sodium level (P < .05), and more frequent multilobar infiltrates (P < .05). The diagnostic scoring system based on these findings showed excellent differentiation between CP and IP (area under the receiver operating characteristic curve, 0.889). Moreover, the prognostic predictors were different between CP and IP. Conclusions: Comprehensive differences between CP and IP were revealed, highlighting the need for early differentiation between these 2 pneumonias in clinical settings. SN - 2328-8957 UR - https://www.unboundmedicine.com/medline/citation/34291119/Pneumonia_Caused_by_Severe_Acute_Respiratory_Syndrome_Coronavirus_2_and_Influenza_Virus:_A_Multicenter_Comparative_Study. L2 - https://academic.oup.com/ofid/article-lookup/doi/10.1093/ofid/ofab282 DB - PRIME DP - Unbound Medicine ER -
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