Tags

Type your tag names separated by a space and hit enter

Thrombotic risk in children with COVID-19 infection: A systematic review of the literature.
Thromb Res. 2021 09; 205:92-98.TR

Abstract

OBJECTIVE

Coagulation and inflammatory parameters are mildly altered in children with SARS-CoV-2 (COVID-19) infection, and laboratory evidence of a proinflammatory and procoagulant state has been noted in multisystem inflammatory syndrome in children (MIS-C). It is not clear whether this pediatric condition is related to thrombotic events. With this study we reviewed the literature for thrombotic complications in children with COVID-19 infection and MIS-C.

DATA SOURCES

We searched the Medline PubMed Advanced Search Builder, Scopus, Web Of Science, and Google Scholar electronic databases (until 1 January 2021) using the medical subject headings (MeSH) terms and text words (their combinations and truncated synonyms): (THROMBOSIS OR THROMBOPHILIA) AND (CHILD OR CHILDREN OR INFANT) AND (COVID-19 OR SARS-CoV-2).

STUDY ELIGIBILITY CRITERIA

Inclusion criteria were children with COVID-19 or SARS-COV-2 infection. The search was limited to articles published in English. Exclusion criteria were: reviews of published studies, studies published only as abstracts, letters or conference proceedings, discussion papers, animal studies, or editorials.

RESULTS

After screening for duplicates, the initial search yielded 86 records: 12 were case reports involving 19 children; comorbidities were absent or mild in 73.7%. The most common site of thrombosis the lung (21%); the most often used drug was heparin (42%). Two studies were an international survey (n = 337 patients) and a large multicenter study (n = 186 patients with MIS-C). The risk of ischemic stroke in SARS-CoV-2 infection (0.82%) and deep venous thrombosis in MIS-C (4.3%) was lower in children than in adults.

CONCLUSIONS

Thrombodic or thromboembolic events are rare in pediatric patients with COVID-19 infection and MIS-C. Nonetheless, as in adults, a high index of suspicion should be maintained in children with COVID-19 infection or MIS-C, particularly in those with comorbidities predisposing to thrombotic events.

Authors+Show Affiliations

Department of Surgical Sciences, Dentistry, Gynecology and Pediatrics, University of Verona, Verona, Italy. Electronic address: marco.zaffanello@univr.it.Department of Surgical Sciences, Dentistry, Gynecology and Pediatrics, University of Verona, Verona, Italy. Electronic address: giorgio.piacentini@univr.it.Lombardy Regional SIDS Center, Division of Pediatrics, F. Del Ponte Hospital, University of Insubria, Varese, Italy. Electronic address: luana.nosetti@uninsubria.it.Pediatric Division, University of Verona, Azienda Ospedaliera Universitaria Integrata, Verona, Italy. Electronic address: stefania.ganzarolli@aovr.veneto.it.Department of Hematology and Transfusion Medicine, Carlo Poma Hospital, Mantova, Italy. Electronic address: massimo.franchini@asst-mantova.it.

Pub Type(s)

Journal Article
Review
Systematic Review

Language

eng

PubMed ID

34293539

Citation

Zaffanello, Marco, et al. "Thrombotic Risk in Children With COVID-19 Infection: a Systematic Review of the Literature." Thrombosis Research, vol. 205, 2021, pp. 92-98.
Zaffanello M, Piacentini G, Nosetti L, et al. Thrombotic risk in children with COVID-19 infection: A systematic review of the literature. Thromb Res. 2021;205:92-98.
Zaffanello, M., Piacentini, G., Nosetti, L., Ganzarolli, S., & Franchini, M. (2021). Thrombotic risk in children with COVID-19 infection: A systematic review of the literature. Thrombosis Research, 205, 92-98. https://doi.org/10.1016/j.thromres.2021.07.011
Zaffanello M, et al. Thrombotic Risk in Children With COVID-19 Infection: a Systematic Review of the Literature. Thromb Res. 2021;205:92-98. PubMed PMID: 34293539.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Thrombotic risk in children with COVID-19 infection: A systematic review of the literature. AU - Zaffanello,Marco, AU - Piacentini,Giorgio, AU - Nosetti,Luana, AU - Ganzarolli,Stefania, AU - Franchini,Massimo, Y1 - 2021/07/16/ PY - 2021/03/17/received PY - 2021/07/09/revised PY - 2021/07/13/accepted PY - 2021/7/23/pubmed PY - 2021/8/13/medline PY - 2021/7/22/entrez KW - COVID-19 KW - Childhood KW - Children KW - SARS-CoV-2 KW - Thrombophilia KW - Thrombosis SP - 92 EP - 98 JF - Thrombosis research JO - Thromb Res VL - 205 N2 - OBJECTIVE: Coagulation and inflammatory parameters are mildly altered in children with SARS-CoV-2 (COVID-19) infection, and laboratory evidence of a proinflammatory and procoagulant state has been noted in multisystem inflammatory syndrome in children (MIS-C). It is not clear whether this pediatric condition is related to thrombotic events. With this study we reviewed the literature for thrombotic complications in children with COVID-19 infection and MIS-C. DATA SOURCES: We searched the Medline PubMed Advanced Search Builder, Scopus, Web Of Science, and Google Scholar electronic databases (until 1 January 2021) using the medical subject headings (MeSH) terms and text words (their combinations and truncated synonyms): (THROMBOSIS OR THROMBOPHILIA) AND (CHILD OR CHILDREN OR INFANT) AND (COVID-19 OR SARS-CoV-2). STUDY ELIGIBILITY CRITERIA: Inclusion criteria were children with COVID-19 or SARS-COV-2 infection. The search was limited to articles published in English. Exclusion criteria were: reviews of published studies, studies published only as abstracts, letters or conference proceedings, discussion papers, animal studies, or editorials. RESULTS: After screening for duplicates, the initial search yielded 86 records: 12 were case reports involving 19 children; comorbidities were absent or mild in 73.7%. The most common site of thrombosis the lung (21%); the most often used drug was heparin (42%). Two studies were an international survey (n = 337 patients) and a large multicenter study (n = 186 patients with MIS-C). The risk of ischemic stroke in SARS-CoV-2 infection (0.82%) and deep venous thrombosis in MIS-C (4.3%) was lower in children than in adults. CONCLUSIONS: Thrombodic or thromboembolic events are rare in pediatric patients with COVID-19 infection and MIS-C. Nonetheless, as in adults, a high index of suspicion should be maintained in children with COVID-19 infection or MIS-C, particularly in those with comorbidities predisposing to thrombotic events. SN - 1879-2472 UR - https://www.unboundmedicine.com/medline/citation/34293539/Thrombotic_risk_in_children_with_COVID-19_infection:_A_systematic_review_of_the_literature. L2 - https://linkinghub.elsevier.com/retrieve/pii/S0049-3848(21)00404-7 DB - PRIME DP - Unbound Medicine ER -