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SARS-CoV-2 anti-spike antibody titres after vaccination with BNT162b2 in naïve and previously infected individuals.
J Infect Public Health. 2021 08; 14(8):1120-1122.JI

Abstract

Great expectations are placed in vaccines against COVID-19 to control the pandemic. We reviewed the antibody titres in a cohort of healthcare workers (HCWs) vaccinated with BNT162b2 to assess the influence of a previous infection on them. We stratified the results according to the individual history of nasopharyngeal swab (NPS) and symptoms. Among 3475 HCWs the highest titres were recorded among those infected more than 6 months before vaccination, independently of symptoms, followed by those infected less than 6 months before vaccination, especially in those with symptoms, and by uninfected HCWs. Vaccination with BNT162b2 can boost immunity acquired through infection, particularly in those infected more than 6 months before vaccination.

Authors+Show Affiliations

Infectious Diseases Unit, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy; Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy. Electronic address: andrea.lombardi@unimi.it.Epidemiology Unit, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.Clinical Laboratory, Foundation IRCCS Ca' Granda Ospedale Maggiore, Milan, Italy.Clinical Laboratory, Foundation IRCCS Ca' Granda Ospedale Maggiore, Milan, Italy.Clinical Laboratory, Foundation IRCCS Ca' Granda Ospedale Maggiore, Milan, Italy.Medical Direction, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.Epidemiology Unit, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy; Department of Clinical Sciences and Community Health, University of Milano, Milan, Italy.Department Biomedical Sciences for Health, University of Milan, Milan, Italy; Quality and Internal Audit Privacy Unit, University of Milan, Milan, Italy.Infectious Diseases Unit, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.Occupational Health Unit, Foundation IRCCS Ca' Granda Ospedale MaggiorePoliclinico, Milan, Italy.Clinical Laboratory, Foundation IRCCS Ca' Granda Ospedale Maggiore, Milan, Italy.Infectious Diseases Unit, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy; Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy; Centre for Multidisciplinary Research in Health Science (MACH), University of Milan, Milan, Italy.Infectious Diseases Unit, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy; Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy; Centre for Multidisciplinary Research in Health Science (MACH), University of Milan, Milan, Italy.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

34293641

Citation

Lombardi, Andrea, et al. "SARS-CoV-2 Anti-spike Antibody Titres After Vaccination With BNT162b2 in Naïve and Previously Infected Individuals." Journal of Infection and Public Health, vol. 14, no. 8, 2021, pp. 1120-1122.
Lombardi A, Consonni D, Oggioni M, et al. SARS-CoV-2 anti-spike antibody titres after vaccination with BNT162b2 in naïve and previously infected individuals. J Infect Public Health. 2021;14(8):1120-1122.
Lombardi, A., Consonni, D., Oggioni, M., Bono, P., Uceda Renteria, S., Piatti, A., Pesatori, A. C., Castaldi, S., Muscatello, A., Riboldi, L., Ceriotti, F., Bandera, A., & Gori, A. (2021). SARS-CoV-2 anti-spike antibody titres after vaccination with BNT162b2 in naïve and previously infected individuals. Journal of Infection and Public Health, 14(8), 1120-1122. https://doi.org/10.1016/j.jiph.2021.07.005
Lombardi A, et al. SARS-CoV-2 Anti-spike Antibody Titres After Vaccination With BNT162b2 in Naïve and Previously Infected Individuals. J Infect Public Health. 2021;14(8):1120-1122. PubMed PMID: 34293641.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - SARS-CoV-2 anti-spike antibody titres after vaccination with BNT162b2 in naïve and previously infected individuals. AU - Lombardi,Andrea, AU - Consonni,Dario, AU - Oggioni,Massimo, AU - Bono,Patrizia, AU - Uceda Renteria,Sara, AU - Piatti,Alessandra, AU - Pesatori,Angela C, AU - Castaldi,Silvana, AU - Muscatello,Antonio, AU - Riboldi,Luciano, AU - Ceriotti,Ferruccio, AU - Bandera,Alessandra, AU - Gori,Andrea, Y1 - 2021/07/17/ PY - 2021/05/24/received PY - 2021/07/03/revised PY - 2021/07/07/accepted PY - 2021/7/23/pubmed PY - 2021/8/4/medline PY - 2021/7/22/entrez KW - BNT162b2 KW - COVID-19 KW - Healthcare workers KW - Vaccination SP - 1120 EP - 1122 JF - Journal of infection and public health JO - J Infect Public Health VL - 14 IS - 8 N2 - Great expectations are placed in vaccines against COVID-19 to control the pandemic. We reviewed the antibody titres in a cohort of healthcare workers (HCWs) vaccinated with BNT162b2 to assess the influence of a previous infection on them. We stratified the results according to the individual history of nasopharyngeal swab (NPS) and symptoms. Among 3475 HCWs the highest titres were recorded among those infected more than 6 months before vaccination, independently of symptoms, followed by those infected less than 6 months before vaccination, especially in those with symptoms, and by uninfected HCWs. Vaccination with BNT162b2 can boost immunity acquired through infection, particularly in those infected more than 6 months before vaccination. SN - 1876-035X UR - https://www.unboundmedicine.com/medline/citation/34293641/SARS-CoV-2_anti-spike_antibody_titres_after_vaccination_with_BNT162b2_in_naïve_and_previously_infected_individuals. L2 - https://linkinghub.elsevier.com/retrieve/pii/S1876-0341(21)00192-1 DB - PRIME DP - Unbound Medicine ER -