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Genetic characterisation for Yan'an Han population in Northern Shaanxi Province, China, via 38Y-STRs using Yfiler™ Platinum.
Ann Hum Biol. 2021 Jun; 48(4):327-334.AH

Abstract

BACKGROUND

Haplotype/allele frequency data of Y-chromosomal STR loci in ethnically diverse populations are essential for forensics, anthropology and genealogy. However, genetic structure and forensic characterisation of the Chinese Han population residing in Yan'an, in the Northern Shaanxi Province, remain unclear.

AIM

To assess forensic efficiency for 38 Y-Chromosomal STR loci in Yan'an Han population and reveal the population genetic relationships between Yan'an Han and other populations at a nationwide and worldwide level.

SUBJECTS AND METHODS

719 healthy unrelated males were genotyped using the Yfiler™ Platinum system. Haplotype/allele frequencies and forensic parameters were calculated. Multi-dimensional scaling plots (MDS) and neighbor-joining (N-J) tree were used to explore the population structure based on the pairwise gene distances (Rst).

RESULTS

A total of 707 haplotypes were identified, among which 697 unique haplotypes were observed (98.59%). The overall haplotype diversity (HD) and discrimination capacity (DC) were 0.9999 and 0.9833, respectively. Comprehensive population comparisons showed Yan'an Han is genetically closer to linguistically similar populations in China, and more related to East Asian populations around the world.

CONCLUSION

The present results give a unique insight into the Yan'an Han population via the set of 38 Y-STRs, which can be used for forensic practice and human genetics research.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Department of Pathology, The First Affiliated Hospital of Xi'an Jiaotong University, Shaanxi, China.

Key Laboratory of Cell Engineering in Guizhou Province, Affiliated Hospital of Zunyi Medical University, Guizhou, China. Center of Forensic Expertise, Affiliated hospital of Zunyi Medical University, Guizhou, China.

Department of Pathology, The First Affiliated Hospital of Xi'an Jiaotong University, Shaanxi, China.

Key Laboratory of Cell Engineering in Guizhou Province, Affiliated Hospital of Zunyi Medical University, Guizhou, China. Center of Forensic Expertise, Affiliated hospital of Zunyi Medical University, Guizhou, China.

Department of Pathology, The First Affiliated Hospital of Xi'an Jiaotong University, Shaanxi, China.

Department of Pathology, The First Affiliated Hospital of Xi'an Jiaotong University, Shaanxi, China.

Department of Pathology, The First Affiliated Hospital of Xi'an Jiaotong University, Shaanxi, China.

Institute of Forensic medicine, West China School of Basic Science and Forensic Medicine, Sichuan University, Sichuan, China.

Department of Forensic Medicine, Inner Mongolia Medical University, Inner Mongolia Autonomous Region, Hohhot, China.

Key Laboratory of Cell Engineering in Guizhou Province, Affiliated Hospital of Zunyi Medical University, Guizhou, China. Center of Forensic Expertise, Affiliated hospital of Zunyi Medical University, Guizhou, China.

MeSH

ChinaChromosomes, Human, YEthnicityGene FrequencyGenetics, PopulationHaplotypesHumansMaleMicrosatellite RepeatsPlatinum

Pub Type(s)

Journal Article

Language

eng

PubMed ID

34308740

Citation

Li, Luyao, et al. "Genetic Characterisation for Yan'an Han Population in Northern Shaanxi Province, China, Via 38Y-STRs Using Yfiler™ Platinum." Annals of Human Biology, vol. 48, no. 4, 2021, pp. 327-334.

Li L, Yao L, Gong H, et al. Genetic characterisation for Yan'an Han population in Northern Shaanxi Province, China, via 38Y-STRs using Yfiler™ Platinum. Ann Hum Biol. 2021;48(4):327-334.

Li, L., Yao, L., Gong, H., Luo, L., Liang, H., Zhang, J., Wang, Y., He, G., Jia, F., & Chen, P. (2021). Genetic characterisation for Yan'an Han population in Northern Shaanxi Province, China, via 38Y-STRs using Yfiler™ Platinum. Annals of Human Biology, 48(4), 327-334. https://doi.org/10.1080/03014460.2021.1951350

Li L, et al. Genetic Characterisation for Yan'an Han Population in Northern Shaanxi Province, China, Via 38Y-STRs Using Yfiler™ Platinum. Ann Hum Biol. 2021;48(4):327-334. PubMed PMID: 34308740.

* Article titles in AMA citation format should be in sentence-case

TY - JOUR T1 - Genetic characterisation for Yan'an Han population in Northern Shaanxi Province, China, via 38Y-STRs using Yfiler™ Platinum. AU - Li,Luyao, AU - Yao,Lilan, AU - Gong,Huilin, AU - Luo,Li, AU - Liang,Hau, AU - Zhang,Jiaojiao, AU - Wang,Yuanyuan, AU - He,Guanglin, AU - Jia,Fuquan, AU - Chen,Pengyu, Y1 - 2021/07/26/ PY - 2021/7/27/pubmed PY - 2021/12/15/medline PY - 2021/7/26/entrez KW - Haplotype diversity KW - Y-chromosomal STR KW - Yan’an Han KW - Yfiler™ Platinum SP - 327 EP - 334 JF - Annals of human biology JO - Ann Hum Biol VL - 48 IS - 4 N2 - BACKGROUND: Haplotype/allele frequency data of Y-chromosomal STR loci in ethnically diverse populations are essential for forensics, anthropology and genealogy. However, genetic structure and forensic characterisation of the Chinese Han population residing in Yan'an, in the Northern Shaanxi Province, remain unclear. AIM: To assess forensic efficiency for 38 Y-Chromosomal STR loci in Yan'an Han population and reveal the population genetic relationships between Yan'an Han and other populations at a nationwide and worldwide level. SUBJECTS AND METHODS: 719 healthy unrelated males were genotyped using the Yfiler™ Platinum system. Haplotype/allele frequencies and forensic parameters were calculated. Multi-dimensional scaling plots (MDS) and neighbor-joining (N-J) tree were used to explore the population structure based on the pairwise gene distances (Rst). RESULTS: A total of 707 haplotypes were identified, among which 697 unique haplotypes were observed (98.59%). The overall haplotype diversity (HD) and discrimination capacity (DC) were 0.9999 and 0.9833, respectively. Comprehensive population comparisons showed Yan'an Han is genetically closer to linguistically similar populations in China, and more related to East Asian populations around the world. CONCLUSION: The present results give a unique insight into the Yan'an Han population via the set of 38 Y-STRs, which can be used for forensic practice and human genetics research. SN - 1464-5033 UR - https://www.unboundmedicine.com/medline/citation/34308740/Genetic_characterisation_for_Yan'an_Han_population_in_Northern_Shaanxi_Province_China_via_38Y_STRs_using_Yfiler™_Platinum_ DB - PRIME DP - Unbound Medicine ER -