Tags

Type your tag names separated by a space and hit enter

Investigation of common risk factors between polycystic ovary syndrome and Alzheimer's disease: a narrative review.
Reprod Health. 2021 Jul 26; 18(1):156.RH

Abstract

BACKGROUND

The most common endocrine and metabolic disorders in premenopausal women is polycystic ovary syndrome (PCOS), characterized by hyperandrogenism, chronic anovulation, and/or ultrasound evidence of small ovarian cysts. Obesity and insulin resistance are also the main factors influencing the clinical manifestations of this syndrome. Alzheimer's disease (AD) is the most typical progressive neurodegenerative disorder of the brain, and recent studies suggest a relationship between endocrinal dysregulation and neuronal loss during AD pathology.

AIM

This study aimed to evaluate the common risk factors for Alzheimer's and PCOS based on previous studies. Knowing the common risk factors and eliminating them may prevent neurodegenerative Alzheimer's disease in the future.

METHOD

In this narrative review, international databases, including Google Scholar, Scopus, PubMed, and the Web of Science, were searched to retrieve the relevant studies. The relevant studies' summaries were categorized to discuss the possible pathways that may explain the association between Alzheimer's and PCOS signs/symptoms and complications.

RESULTS

According to our research, the factors involved in Alzheimer's and PCOS disorders may share some common risk factors. In patients with PCOS, increased LH to FSH ratio, decreased vitamin D, insulin resistance, and obesity are some of the most important factors that may increase the risk of Alzheimer's disease.

Links

PMC Free PDF

Authors+Show Affiliations

Sarahian N
Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Sarvazad H
Clinical Research Development Center, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Sajadi E
Department of Basic Science, School of Veterinary Medicine, Shiraz University, Shiraz, Iran.
Rahnejat N
Faculty of Nursing and Midwifery, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Eskandari Roozbahani N
Clinical Research Development Center, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran. neskandari32@gmail.com.

MeSH

Alzheimer DiseaseAnovulationFemaleHumansHyperandrogenismInsulin ResistancePolycystic Ovary SyndromeRisk Factors

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

34311759

Citation

Sarahian, Nahid, et al. "Investigation of Common Risk Factors Between Polycystic Ovary Syndrome and Alzheimer's Disease: a Narrative Review." Reproductive Health, vol. 18, no. 1, 2021, p. 156.
Sarahian N, Sarvazad H, Sajadi E, et al. Investigation of common risk factors between polycystic ovary syndrome and Alzheimer's disease: a narrative review. Reprod Health. 2021;18(1):156.
Sarahian, N., Sarvazad, H., Sajadi, E., Rahnejat, N., & Eskandari Roozbahani, N. (2021). Investigation of common risk factors between polycystic ovary syndrome and Alzheimer's disease: a narrative review. Reproductive Health, 18(1), 156. https://doi.org/10.1186/s12978-021-01203-x
Sarahian N, et al. Investigation of Common Risk Factors Between Polycystic Ovary Syndrome and Alzheimer's Disease: a Narrative Review. Reprod Health. 2021 Jul 26;18(1):156. PubMed PMID: 34311759.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Investigation of common risk factors between polycystic ovary syndrome and Alzheimer's disease: a narrative review. AU - Sarahian,Nahid, AU - Sarvazad,Hosna, AU - Sajadi,Elham, AU - Rahnejat,Nasrin, AU - Eskandari Roozbahani,Narges, Y1 - 2021/07/26/ PY - 2021/04/01/received PY - 2021/07/13/accepted PY - 2021/7/27/entrez PY - 2021/7/28/pubmed PY - 2021/7/29/medline KW - Alzheimer disease KW - Hyperandrogenism KW - Insulin resistance KW - Polycystic ovary syndrome KW - Review SP - 156 EP - 156 JF - Reproductive health JO - Reprod Health VL - 18 IS - 1 N2 - BACKGROUND: The most common endocrine and metabolic disorders in premenopausal women is polycystic ovary syndrome (PCOS), characterized by hyperandrogenism, chronic anovulation, and/or ultrasound evidence of small ovarian cysts. Obesity and insulin resistance are also the main factors influencing the clinical manifestations of this syndrome. Alzheimer's disease (AD) is the most typical progressive neurodegenerative disorder of the brain, and recent studies suggest a relationship between endocrinal dysregulation and neuronal loss during AD pathology. AIM: This study aimed to evaluate the common risk factors for Alzheimer's and PCOS based on previous studies. Knowing the common risk factors and eliminating them may prevent neurodegenerative Alzheimer's disease in the future. METHOD: In this narrative review, international databases, including Google Scholar, Scopus, PubMed, and the Web of Science, were searched to retrieve the relevant studies. The relevant studies' summaries were categorized to discuss the possible pathways that may explain the association between Alzheimer's and PCOS signs/symptoms and complications. RESULTS: According to our research, the factors involved in Alzheimer's and PCOS disorders may share some common risk factors. In patients with PCOS, increased LH to FSH ratio, decreased vitamin D, insulin resistance, and obesity are some of the most important factors that may increase the risk of Alzheimer's disease. SN - 1742-4755 UR - https://www.unboundmedicine.com/medline/citation/34311759/Investigation_of_common_risk_factors_between_polycystic_ovary_syndrome_and_Alzheimer's_disease:_a_narrative_review_ DB - PRIME DP - Unbound Medicine ER -