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Results of an open clinical trial of brofaromine (CGP 11 305 A), a competitive, selective, and short-acting inhibitor of MAO-A in major endogenous depression.
Pharmacopsychiatry. 1987 Nov; 20(6):262-9.P

Abstract

In an open clinical trial the authors treated 18 hospitalized patients suffering from endogenous depression with brofaromine (CGP 11305A), a competitive, selective, and short-acting inhibitor of type A monoamine oxidase (MAO). Four patients were defined as good responders, as they had a final HAMD score of between 0 and 7 points. Four patients were judged as improved, with final HAMD scores of between 8 and 15 points, while the remaining eight patients failed to respond (final HAMD score greater than or equal to 16 points). The major observations were a beneficial influence on drive in most patients, while paranoid symptoms worsened markedly, rendering the substance contraindicated in psychotic depression. Brofaromine appears to be safe and well tolerated and largely free of side effects. As objectified by the tyramine pressor test, dietary restrictions during brofaromine treatment require less stringency than is the case with conventional MAO inhibitors. The specificity of brofaromine to inhibit deamination is limited to MAO-A, since no reduction in platelet MAO activity was measurable. Sleep EEG recordings in a subset of patients reveals that the amount of rapid eye movement (REM) sleep is significantly reduced during brofaromine treatment.

Authors+Show Affiliations

Department of Psychiatry, University of Mainz, FRG.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

3432361

Citation

Steiger, A, et al. "Results of an Open Clinical Trial of Brofaromine (CGP 11 305 A), a Competitive, Selective, and Short-acting Inhibitor of MAO-A in Major Endogenous Depression." Pharmacopsychiatry, vol. 20, no. 6, 1987, pp. 262-9.
Steiger A, Holsboer F, Gerken A, et al. Results of an open clinical trial of brofaromine (CGP 11 305 A), a competitive, selective, and short-acting inhibitor of MAO-A in major endogenous depression. Pharmacopsychiatry. 1987;20(6):262-9.
Steiger, A., Holsboer, F., Gerken, A., Demisch, L., & Benkert, O. (1987). Results of an open clinical trial of brofaromine (CGP 11 305 A), a competitive, selective, and short-acting inhibitor of MAO-A in major endogenous depression. Pharmacopsychiatry, 20(6), 262-9.
Steiger A, et al. Results of an Open Clinical Trial of Brofaromine (CGP 11 305 A), a Competitive, Selective, and Short-acting Inhibitor of MAO-A in Major Endogenous Depression. Pharmacopsychiatry. 1987;20(6):262-9. PubMed PMID: 3432361.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Results of an open clinical trial of brofaromine (CGP 11 305 A), a competitive, selective, and short-acting inhibitor of MAO-A in major endogenous depression. AU - Steiger,A, AU - Holsboer,F, AU - Gerken,A, AU - Demisch,L, AU - Benkert,O, PY - 1987/11/1/pubmed PY - 1987/11/1/medline PY - 1987/11/1/entrez SP - 262 EP - 9 JF - Pharmacopsychiatry JO - Pharmacopsychiatry VL - 20 IS - 6 N2 - In an open clinical trial the authors treated 18 hospitalized patients suffering from endogenous depression with brofaromine (CGP 11305A), a competitive, selective, and short-acting inhibitor of type A monoamine oxidase (MAO). Four patients were defined as good responders, as they had a final HAMD score of between 0 and 7 points. Four patients were judged as improved, with final HAMD scores of between 8 and 15 points, while the remaining eight patients failed to respond (final HAMD score greater than or equal to 16 points). The major observations were a beneficial influence on drive in most patients, while paranoid symptoms worsened markedly, rendering the substance contraindicated in psychotic depression. Brofaromine appears to be safe and well tolerated and largely free of side effects. As objectified by the tyramine pressor test, dietary restrictions during brofaromine treatment require less stringency than is the case with conventional MAO inhibitors. The specificity of brofaromine to inhibit deamination is limited to MAO-A, since no reduction in platelet MAO activity was measurable. Sleep EEG recordings in a subset of patients reveals that the amount of rapid eye movement (REM) sleep is significantly reduced during brofaromine treatment. SN - 0176-3679 UR - https://www.unboundmedicine.com/medline/citation/3432361/Results_of_an_open_clinical_trial_of_brofaromine__CGP_11_305_A__a_competitive_selective_and_short_acting_inhibitor_of_MAO_A_in_major_endogenous_depression_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-2007-1017119 DB - PRIME DP - Unbound Medicine ER -