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Estimation of the antral and duodenal gastrin cell population removed by gastrectomy from patients with peptic ulcer.
Surg Gynecol Obstet. 1978 Mar; 146(3):400-6.SG

Abstract

The total number of gastric and duodenal gastrin cells was determined in the gastrectomy specimens from eight patients with peptic ulcer. Planimetry was used to determine the antral and duodenal surface. The immunoperoxydase method with specific antigastrin antibodies was used for staining gastrin cells, and the mean concentration of nucleated gastrin cells per square millimeter of antral and duodenal surface was determined by light microscopy. The mean number of duodenal gastrin cells in the resected duodenum was 4.8 per cent of the total gastric gastrin cell mass. The concentration of gastrin cells in the antrum was quite variable from one mucosal site to another. The degree of extension of the antral gastritic areas was a major factor influencing the mean concentration value. The total number of gastrin cells in the stomach varied from approximately 7 to 74 million cells. Our data indicate that hyperplasia of gastrin cells cannot be demonstrated by studies performed in small specimens taken for biopsy.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

343279

Citation

Keuppens, F, et al. "Estimation of the Antral and Duodenal Gastrin Cell Population Removed By Gastrectomy From Patients With Peptic Ulcer." Surgery, Gynecology & Obstetrics, vol. 146, no. 3, 1978, pp. 400-6.
Keuppens F, Willems G, Vansteenkiste Y, et al. Estimation of the antral and duodenal gastrin cell population removed by gastrectomy from patients with peptic ulcer. Surg Gynecol Obstet. 1978;146(3):400-6.
Keuppens, F., Willems, G., Vansteenkiste, Y., & Woussen-Colle, M. C. (1978). Estimation of the antral and duodenal gastrin cell population removed by gastrectomy from patients with peptic ulcer. Surgery, Gynecology & Obstetrics, 146(3), 400-6.
Keuppens F, et al. Estimation of the Antral and Duodenal Gastrin Cell Population Removed By Gastrectomy From Patients With Peptic Ulcer. Surg Gynecol Obstet. 1978;146(3):400-6. PubMed PMID: 343279.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Estimation of the antral and duodenal gastrin cell population removed by gastrectomy from patients with peptic ulcer. AU - Keuppens,F, AU - Willems,G, AU - Vansteenkiste,Y, AU - Woussen-Colle,M C, PY - 1978/3/1/pubmed PY - 1978/3/1/medline PY - 1978/3/1/entrez SP - 400 EP - 6 JF - Surgery, gynecology & obstetrics JO - Surg Gynecol Obstet VL - 146 IS - 3 N2 - The total number of gastric and duodenal gastrin cells was determined in the gastrectomy specimens from eight patients with peptic ulcer. Planimetry was used to determine the antral and duodenal surface. The immunoperoxydase method with specific antigastrin antibodies was used for staining gastrin cells, and the mean concentration of nucleated gastrin cells per square millimeter of antral and duodenal surface was determined by light microscopy. The mean number of duodenal gastrin cells in the resected duodenum was 4.8 per cent of the total gastric gastrin cell mass. The concentration of gastrin cells in the antrum was quite variable from one mucosal site to another. The degree of extension of the antral gastritic areas was a major factor influencing the mean concentration value. The total number of gastrin cells in the stomach varied from approximately 7 to 74 million cells. Our data indicate that hyperplasia of gastrin cells cannot be demonstrated by studies performed in small specimens taken for biopsy. SN - 0039-6087 UR - https://www.unboundmedicine.com/medline/citation/343279/Estimation_of_the_antral_and_duodenal_gastrin_cell_population_removed_by_gastrectomy_from_patients_with_peptic_ulcer_ L2 - https://medlineplus.gov/pepticulcer.html DB - PRIME DP - Unbound Medicine ER -