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The effect of soy protein containing soy isoflavones on serum concentration of cell adhesion molecules: A systematic review and meta-analysis of randomized controlled trials.
Complement Ther Med. 2021 Sep; 61:102764.CT

Abstract

BACKGROUND

Soy protein in combination with soy isoflavones might reduce the serum concentration of inflammatory mediators. In this study, we attempted to summarize the effect of soy protein combined with soy isoflavones on circulating E-selectin, intercellular adhesion molecule-1 (ICAM-1), and vascular cell adhesion molecule-1 (VCAM-1) in adults.

METHODS

Clinicaltrials.gov, Web of Science, Cochrane Library, PubMed, and Scopus were searched for English articles with no time limit regarding publication up to December 2020. Thereafter, the mean changes from baseline and their standard deviations (SDs) for both intervention and comparison groups were used to calculate the effect size. We used DerSimonian and Laird random-effects model if the heterogeneity test was statistically significant. Cochran's Q test and I-squared statistic were also used to calculate the statistical heterogeneity of the intervention effects.

RESULTS

Eight articles were found as eligible for this study. The treatment duration was between 6 and 24 weeks. Soy isoflavones dose was in a range of 30-112 mg/day and soy protein dose was in a range of 11.25-52 g/day. Overall, taking soy protein supplements containing soy isoflavones was not associated with changes in cell adhesion molecules, E-selectin, ICAM-1, or VCAM-1 (WMD = 0.65, 95 % CI: -2.58, 3.89; p = 0.692; WMD = 2.68, 95 % CI: -0.98, 6.34; p = 0.151; WMD = 2.66, 95 % CI: -6.28, 11.61; p = 0.559, respectively).

CONCLUSION

The combination of soy protein and soy isoflavones was not significantly associated with changes in levels of E-selectin, ICAM-1, and VCAM-1. However, we need more studies with a large sample size and more participants with different age categories in this regard.

Authors+Show Affiliations

Noncommunicable Diseases Research Center, Neyshabur University of Medical Sciences, Neyshabur, Iran; Healthy Ageing Research Centre, Neyshabur University of Medical Sciences, Neyshabur, Iran.Department of Epidemiology, School of Public Health, Iran University of Medical Sciences, Tehran, Iran; Ageing Clinical and Experimental Research Team, Institute of Applied Health Sciences, School of Medicine, Medical Sciences and Nutrition University of Aberdeen, Aberdeen, UK.Noncommunicable Diseases Research Center, Neyshabur University of Medical Sciences, Neyshabur, Iran; Department of Epidemiology and Biostatistics, School of Public Health, Neyshabur University of Medical Sciences, Neyshabur, Iran. Electronic address: Gholamia1@nums.ac.ir.

Pub Type(s)

Journal Article
Meta-Analysis
Review
Systematic Review

Language

eng

PubMed ID

34333131

Citation

Hariri, Mitra, et al. "The Effect of Soy Protein Containing Soy Isoflavones On Serum Concentration of Cell Adhesion Molecules: a Systematic Review and Meta-analysis of Randomized Controlled Trials." Complementary Therapies in Medicine, vol. 61, 2021, p. 102764.
Hariri M, Baradaran HR, Gholami A. The effect of soy protein containing soy isoflavones on serum concentration of cell adhesion molecules: A systematic review and meta-analysis of randomized controlled trials. Complement Ther Med. 2021;61:102764.
Hariri, M., Baradaran, H. R., & Gholami, A. (2021). The effect of soy protein containing soy isoflavones on serum concentration of cell adhesion molecules: A systematic review and meta-analysis of randomized controlled trials. Complementary Therapies in Medicine, 61, 102764. https://doi.org/10.1016/j.ctim.2021.102764
Hariri M, Baradaran HR, Gholami A. The Effect of Soy Protein Containing Soy Isoflavones On Serum Concentration of Cell Adhesion Molecules: a Systematic Review and Meta-analysis of Randomized Controlled Trials. Complement Ther Med. 2021;61:102764. PubMed PMID: 34333131.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of soy protein containing soy isoflavones on serum concentration of cell adhesion molecules: A systematic review and meta-analysis of randomized controlled trials. AU - Hariri,Mitra, AU - Baradaran,Hamid Reza, AU - Gholami,Ali, Y1 - 2021/07/29/ PY - 2020/11/23/received PY - 2021/07/28/revised PY - 2021/07/28/accepted PY - 2021/8/2/pubmed PY - 2021/11/25/medline PY - 2021/8/1/entrez KW - E-selectin KW - Intercellular adhesion molecule-1 KW - Isoflavones KW - Soy foods KW - Vascular cell adhesion molecule-1 SP - 102764 EP - 102764 JF - Complementary therapies in medicine JO - Complement Ther Med VL - 61 N2 - BACKGROUND: Soy protein in combination with soy isoflavones might reduce the serum concentration of inflammatory mediators. In this study, we attempted to summarize the effect of soy protein combined with soy isoflavones on circulating E-selectin, intercellular adhesion molecule-1 (ICAM-1), and vascular cell adhesion molecule-1 (VCAM-1) in adults. METHODS: Clinicaltrials.gov, Web of Science, Cochrane Library, PubMed, and Scopus were searched for English articles with no time limit regarding publication up to December 2020. Thereafter, the mean changes from baseline and their standard deviations (SDs) for both intervention and comparison groups were used to calculate the effect size. We used DerSimonian and Laird random-effects model if the heterogeneity test was statistically significant. Cochran's Q test and I-squared statistic were also used to calculate the statistical heterogeneity of the intervention effects. RESULTS: Eight articles were found as eligible for this study. The treatment duration was between 6 and 24 weeks. Soy isoflavones dose was in a range of 30-112 mg/day and soy protein dose was in a range of 11.25-52 g/day. Overall, taking soy protein supplements containing soy isoflavones was not associated with changes in cell adhesion molecules, E-selectin, ICAM-1, or VCAM-1 (WMD = 0.65, 95 % CI: -2.58, 3.89; p = 0.692; WMD = 2.68, 95 % CI: -0.98, 6.34; p = 0.151; WMD = 2.66, 95 % CI: -6.28, 11.61; p = 0.559, respectively). CONCLUSION: The combination of soy protein and soy isoflavones was not significantly associated with changes in levels of E-selectin, ICAM-1, and VCAM-1. However, we need more studies with a large sample size and more participants with different age categories in this regard. SN - 1873-6963 UR - https://www.unboundmedicine.com/medline/citation/34333131/The_effect_of_soy_protein_containing_soy_isoflavones_on_serum_concentration_of_cell_adhesion_molecules:_A_systematic_review_and_meta_analysis_of_randomized_controlled_trials_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0965-2299(21)00105-9 DB - PRIME DP - Unbound Medicine ER -