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Regulation of Mild Moxibustion on Uterine Vascular and Prostaglandin Contents in Primary Dysmenorrhea Rat Model.
Evid Based Complement Alternat Med. 2021; 2021:9949642.EB

Abstract

OBJECTIVE

Primary dysmenorrhea (PD) is a common and high incidence disease in gynecology, which seriously affects the quality of life in young women. Our previous study found that mild moxibustion could treat abdominal pain of PD patients, but the mechanism is still unclear. Therefore, this study aims to partly investigate the treatment mechanism of moxibustion for PD, especially on uterine microcirculation.

METHODS

Forty 3-month-old Sprague Dawley female rats were randomly divided into four groups, including group A (saline control group, n = 10), group B (control plus moxibustion group, n = 10), group C (PD model group, n = 10), group D (PD. model plus moxibustion group, n = 10). The PD rat model was established by injecting estradiol benzoate and oxytocin. Mild moxibustion on Sanyinjiao (SP6) and Guanyuan (CV4) acupoints was once a day, 20 minutes per time, for 10 consecutive days. A vaginal smear was used to test the estrous cycle of rats. Uterine microvascular thickness was observed by stereomicroscope. And we detected the content of prostaglandin F2α (PGF2α) and prostaglandin E2 (PGE2) in uterine tissue by enzyme-linked immunosorbent assay.

RESULTS

Mild moxibustion can enlarge the microvessels, improve the microcirculation disturbance, and relieve the swelling of the uterus in PD rats. During the mild moxibustion intervention, the contents of PGF2α and PGE2 in uterus issues were synchronous increases or decreases and the changes of PGE2 were more obvious, but the changes of uterine microvasculature and morphology caused by the decrease of PGF2α were greater than PGE2.

CONCLUSION

Mild moxibustion at SP6 and CV4 acupoints may relax uterine microvascular obstacle by reducing the content of PGF2α in uterine tissue, improve the microcirculation disorder, and then alleviate the PD rat's uterine swelling.

Authors+Show Affiliations

Acupuncture and Tuina School/The 3rd Teaching Hospital, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.Acupuncture and Tuina School/The 3rd Teaching Hospital, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.Chengdu Pidu District Hospital of Traditional Chinese Medicine, Chengdu, Sichuan, China.Acupuncture and Tuina School/The 3rd Teaching Hospital, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.Acupuncture and Tuina School/The 3rd Teaching Hospital, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.Acupuncture and Tuina School/The 3rd Teaching Hospital, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.Acupuncture and Tuina School/The 3rd Teaching Hospital, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

34335847

Citation

Li, Xuemei, et al. "Regulation of Mild Moxibustion On Uterine Vascular and Prostaglandin Contents in Primary Dysmenorrhea Rat Model." Evidence-based Complementary and Alternative Medicine : ECAM, vol. 2021, 2021, p. 9949642.
Li X, Guo S, Chen Z, et al. Regulation of Mild Moxibustion on Uterine Vascular and Prostaglandin Contents in Primary Dysmenorrhea Rat Model. Evid Based Complement Alternat Med. 2021;2021:9949642.
Li, X., Guo, S., Chen, Z., Ren, K., Zhang, H., Yu, S., & Yang, S. (2021). Regulation of Mild Moxibustion on Uterine Vascular and Prostaglandin Contents in Primary Dysmenorrhea Rat Model. Evidence-based Complementary and Alternative Medicine : ECAM, 2021, 9949642. https://doi.org/10.1155/2021/9949642
Li X, et al. Regulation of Mild Moxibustion On Uterine Vascular and Prostaglandin Contents in Primary Dysmenorrhea Rat Model. Evid Based Complement Alternat Med. 2021;2021:9949642. PubMed PMID: 34335847.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Regulation of Mild Moxibustion on Uterine Vascular and Prostaglandin Contents in Primary Dysmenorrhea Rat Model. AU - Li,Xuemei, AU - Guo,Sha, AU - Chen,Zhaoheng, AU - Ren,Kuiyu, AU - Zhang,Hong, AU - Yu,Shuguang, AU - Yang,Sha, Y1 - 2021/07/10/ PY - 2021/04/05/received PY - 2021/05/16/revised PY - 2021/06/28/accepted PY - 2021/8/2/entrez PY - 2021/8/3/pubmed PY - 2021/8/3/medline SP - 9949642 EP - 9949642 JF - Evidence-based complementary and alternative medicine : eCAM JO - Evid Based Complement Alternat Med VL - 2021 N2 - OBJECTIVE: Primary dysmenorrhea (PD) is a common and high incidence disease in gynecology, which seriously affects the quality of life in young women. Our previous study found that mild moxibustion could treat abdominal pain of PD patients, but the mechanism is still unclear. Therefore, this study aims to partly investigate the treatment mechanism of moxibustion for PD, especially on uterine microcirculation. METHODS: Forty 3-month-old Sprague Dawley female rats were randomly divided into four groups, including group A (saline control group, n = 10), group B (control plus moxibustion group, n = 10), group C (PD model group, n = 10), group D (PD. model plus moxibustion group, n = 10). The PD rat model was established by injecting estradiol benzoate and oxytocin. Mild moxibustion on Sanyinjiao (SP6) and Guanyuan (CV4) acupoints was once a day, 20 minutes per time, for 10 consecutive days. A vaginal smear was used to test the estrous cycle of rats. Uterine microvascular thickness was observed by stereomicroscope. And we detected the content of prostaglandin F2α (PGF2α) and prostaglandin E2 (PGE2) in uterine tissue by enzyme-linked immunosorbent assay. RESULTS: Mild moxibustion can enlarge the microvessels, improve the microcirculation disturbance, and relieve the swelling of the uterus in PD rats. During the mild moxibustion intervention, the contents of PGF2α and PGE2 in uterus issues were synchronous increases or decreases and the changes of PGE2 were more obvious, but the changes of uterine microvasculature and morphology caused by the decrease of PGF2α were greater than PGE2. CONCLUSION: Mild moxibustion at SP6 and CV4 acupoints may relax uterine microvascular obstacle by reducing the content of PGF2α in uterine tissue, improve the microcirculation disorder, and then alleviate the PD rat's uterine swelling. SN - 1741-427X UR - https://www.unboundmedicine.com/medline/citation/34335847/Regulation_of_Mild_Moxibustion_on_Uterine_Vascular_and_Prostaglandin_Contents_in_Primary_Dysmenorrhea_Rat_Model_ L2 - https://doi.org/10.1155/2021/9949642 DB - PRIME DP - Unbound Medicine ER -
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