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Haemodynamic and metabolic consequences of reversed portal venous blood flow after side-to-side portacaval shunt in the dog.
Acta Chir Scand. 1987 Nov-Dec; 153(11-12):653-8.AC

Abstract

The immediate haemodynamic and metabolic effects of reversed portal blood flow after side-to-side portacaval shunt were studied in 9 normal anaesthetized dogs, and compared to those observed after end-to-side shunt in the same animals. Blood flow in the hepatic artery (HA) and portal vein (PV) was measured using electromagnetic flowmeters. The magnitude of the HA hyperaemic response to side-to-side shunt was similar to that found after end-to-side shunt, but approximately one-third of the flow left the liver via the PV. There was no significant correlation between the HA response and the magnitude of reversed PV flow after side-to-side shunt. Despite fairly well preserved total hepatic oxygen consumption in both groups, there was a statistically significant decrease in the side-to-side series; moreover, only 13% of the total hepatic oxygen consumption was derived from blood draining the liver via the PV. It is concluded that the substantial quantity of portally drained blood after side-to-side shunt traverses metabolically inefficient pathways in the liver, and may have a detrimental influence on long-term liver function.

Authors+Show Affiliations

Mathie RT
Department of Surgery, Royal Postgraduate Medical School, Hammersmith Hospital, London, United Kingdom.
Blumgart LH
No affiliation info available

MeSH

AnimalsBlood PressureDogsFemaleLiverLiver CirculationMaleOxygen ConsumptionPortacaval Shunt, SurgicalPortal SystemVascular Resistance

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

3434108

Citation

Mathie, R T., and L H. Blumgart. "Haemodynamic and Metabolic Consequences of Reversed Portal Venous Blood Flow After Side-to-side Portacaval Shunt in the Dog." Acta Chirurgica Scandinavica, vol. 153, no. 11-12, 1987, pp. 653-8.
Mathie RT, Blumgart LH. Haemodynamic and metabolic consequences of reversed portal venous blood flow after side-to-side portacaval shunt in the dog. Acta Chir Scand. 1987;153(11-12):653-8.
Mathie, R. T., & Blumgart, L. H. (1987). Haemodynamic and metabolic consequences of reversed portal venous blood flow after side-to-side portacaval shunt in the dog. Acta Chirurgica Scandinavica, 153(11-12), 653-8.
Mathie RT, Blumgart LH. Haemodynamic and Metabolic Consequences of Reversed Portal Venous Blood Flow After Side-to-side Portacaval Shunt in the Dog. Acta Chir Scand. 1987 Nov-Dec;153(11-12):653-8. PubMed PMID: 3434108.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Haemodynamic and metabolic consequences of reversed portal venous blood flow after side-to-side portacaval shunt in the dog. AU - Mathie,R T, AU - Blumgart,L H, PY - 1987/11/1/pubmed PY - 1987/11/1/medline PY - 1987/11/1/entrez SP - 653 EP - 8 JF - Acta chirurgica Scandinavica JO - Acta Chir Scand VL - 153 IS - 11-12 N2 - The immediate haemodynamic and metabolic effects of reversed portal blood flow after side-to-side portacaval shunt were studied in 9 normal anaesthetized dogs, and compared to those observed after end-to-side shunt in the same animals. Blood flow in the hepatic artery (HA) and portal vein (PV) was measured using electromagnetic flowmeters. The magnitude of the HA hyperaemic response to side-to-side shunt was similar to that found after end-to-side shunt, but approximately one-third of the flow left the liver via the PV. There was no significant correlation between the HA response and the magnitude of reversed PV flow after side-to-side shunt. Despite fairly well preserved total hepatic oxygen consumption in both groups, there was a statistically significant decrease in the side-to-side series; moreover, only 13% of the total hepatic oxygen consumption was derived from blood draining the liver via the PV. It is concluded that the substantial quantity of portally drained blood after side-to-side shunt traverses metabolically inefficient pathways in the liver, and may have a detrimental influence on long-term liver function. SN - 0001-5482 UR - https://www.unboundmedicine.com/medline/citation/3434108/Haemodynamic_and_metabolic_consequences_of_reversed_portal_venous_blood_flow_after_side_to_side_portacaval_shunt_in_the_dog_ DB - PRIME DP - Unbound Medicine ER -