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Neuroprotective Potential of Limonene and Limonene Containing Natural Products.
Molecules. 2021 Jul 27; 26(15)M

Abstract

Limonene is a monoterpene confined to the family of Rutaceae, showing several biological properties such as antioxidant, anti-inflammatory, anticancer, antinociceptive and gastroprotective characteristics. Recently, there is notable interest in investigating the pharmacological effects of limonene in various chronic diseases due to its mitigating effect on oxidative stress and inflammation and regulating apoptotic cell death. There are several available studies demonstrating the neuroprotective role of limonene in neurodegenerative diseases, including Alzheimer's disease, multiple sclerosis, epilepsy, anxiety, and stroke. The high abundance of limonene in nature, its safety profile, and various mechanisms of action make this monoterpene a favorable molecule to be developed as a nutraceutical for preventive purposes and as an alternative agent or adjuvant to modern therapeutic drugs in curbing the onset and progression of neurodegenerative diseases. This manuscript presents a comprehensive review of the available scientific literature discussing the pharmacological activities of limonene or plant products containing limonene which attribute to the protective and therapeutic ability in neurodegenerative disorders. This review has been compiled based on the existing published articles confined to limonene or limonene-containing natural products investigated for their neurotherapeutic or neuroprotective potential. All the articles available in English or the abstract in English were extracted from different databases that offer an access to diverse journals. These databases are PubMed, Scopus, Google Scholar, and Science Direct. Collectively, this review emphasizes the neuroprotective potential of limonene against neurodegenerative and other neuroinflammatory diseases. The available data are indicative of the nutritional use of products containing limonene and the pharmacological actions and mechanisms of limonene and may direct future preclinical and clinical studies for the development of limonene as an alternative or complementary phytomedicine. The pharmacophore can also provide a blueprint for further drug discovery using numerous drug discovery tools.

Authors+Show Affiliations

Department of Pharmacology and Therapeutics, College of Medicine and Health Sciences, United Arab Emirates University, P.O. Box 17666, Al Ain 17666, United Arab Emirates.Department of Biotechnology, School of Engineering & Technology, Sharda University, Greater Noida, Uttar Pradesh 201310, India.Department of Pharmacology and Therapeutics, College of Medicine and Health Sciences, United Arab Emirates University, P.O. Box 17666, Al Ain 17666, United Arab Emirates.Department of Applied Physics, School of Science, Aalto University, 00076 Espoo, Finland. Department of Bioproducts and Biosystems, School of Chemical Engineering, Aalto University, 00076 Espoo, Finland.Department of Pharmacology and Therapeutics, College of Medicine and Health Sciences, United Arab Emirates University, P.O. Box 17666, Al Ain 17666, United Arab Emirates.Department of Pharmacology and Therapeutics, College of Medicine and Health Sciences, United Arab Emirates University, P.O. Box 17666, Al Ain 17666, United Arab Emirates.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

34361686

Citation

Eddin, Lujain Bader, et al. "Neuroprotective Potential of Limonene and Limonene Containing Natural Products." Molecules (Basel, Switzerland), vol. 26, no. 15, 2021.
Eddin LB, Jha NK, Meeran MFN, et al. Neuroprotective Potential of Limonene and Limonene Containing Natural Products. Molecules. 2021;26(15).
Eddin, L. B., Jha, N. K., Meeran, M. F. N., Kesari, K. K., Beiram, R., & Ojha, S. (2021). Neuroprotective Potential of Limonene and Limonene Containing Natural Products. Molecules (Basel, Switzerland), 26(15). https://doi.org/10.3390/molecules26154535
Eddin LB, et al. Neuroprotective Potential of Limonene and Limonene Containing Natural Products. Molecules. 2021 Jul 27;26(15) PubMed PMID: 34361686.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neuroprotective Potential of Limonene and Limonene Containing Natural Products. AU - Eddin,Lujain Bader, AU - Jha,Niraj Kumar, AU - Meeran,M F Nagoor, AU - Kesari,Kavindra Kumar, AU - Beiram,Rami, AU - Ojha,Shreesh, Y1 - 2021/07/27/ PY - 2021/07/01/received PY - 2021/07/17/revised PY - 2021/07/20/accepted PY - 2021/8/7/entrez PY - 2021/8/8/pubmed PY - 2021/9/25/medline KW - citrus terpenes KW - limonene KW - neurodegeneration KW - neuroprotection KW - neuroprotective KW - neurotherapeutics JF - Molecules (Basel, Switzerland) JO - Molecules VL - 26 IS - 15 N2 - Limonene is a monoterpene confined to the family of Rutaceae, showing several biological properties such as antioxidant, anti-inflammatory, anticancer, antinociceptive and gastroprotective characteristics. Recently, there is notable interest in investigating the pharmacological effects of limonene in various chronic diseases due to its mitigating effect on oxidative stress and inflammation and regulating apoptotic cell death. There are several available studies demonstrating the neuroprotective role of limonene in neurodegenerative diseases, including Alzheimer's disease, multiple sclerosis, epilepsy, anxiety, and stroke. The high abundance of limonene in nature, its safety profile, and various mechanisms of action make this monoterpene a favorable molecule to be developed as a nutraceutical for preventive purposes and as an alternative agent or adjuvant to modern therapeutic drugs in curbing the onset and progression of neurodegenerative diseases. This manuscript presents a comprehensive review of the available scientific literature discussing the pharmacological activities of limonene or plant products containing limonene which attribute to the protective and therapeutic ability in neurodegenerative disorders. This review has been compiled based on the existing published articles confined to limonene or limonene-containing natural products investigated for their neurotherapeutic or neuroprotective potential. All the articles available in English or the abstract in English were extracted from different databases that offer an access to diverse journals. These databases are PubMed, Scopus, Google Scholar, and Science Direct. Collectively, this review emphasizes the neuroprotective potential of limonene against neurodegenerative and other neuroinflammatory diseases. The available data are indicative of the nutritional use of products containing limonene and the pharmacological actions and mechanisms of limonene and may direct future preclinical and clinical studies for the development of limonene as an alternative or complementary phytomedicine. The pharmacophore can also provide a blueprint for further drug discovery using numerous drug discovery tools. SN - 1420-3049 UR - https://www.unboundmedicine.com/medline/citation/34361686/Neuroprotective_Potential_of_Limonene_and_Limonene_Containing_Natural_Products_ DB - PRIME DP - Unbound Medicine ER -