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The use of urinary biomarkers in the diagnosis of overactive bladder in female patients. A systematic review and meta-analysis.
Int Urogynecol J. 2021 Dec; 32(12):3143-3155.IU

Abstract

INTRODUCTION AND HYPOTHESIS

Nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and other proteins are related to overactive bladder (OAB) syndrome, as their urinary concentrations are significantly different from those of the general non-OAB population. This review aims to systematically assess whether NGF, BDNF, and other urinary by-products can be used as potential biomarkers to manage women with OAB.

METHODS

This was a systematic review and metanalysis that was conducted according to PRISMA guidelines. Studies were identified by electronic search of Medline, Scopus, ScienceDirect, Embase, and Cochrane Register until October 2020. The included studies investigated the correlation of OAB with NGF, BDNF, and other potential biomarkers in symptomatic women and their controls.

RESULTS

Twelve studies (581 female OAB patients and 394 female controls) were included. Urinary NGF, NGF/Cr, BDNF/Cr, ATP/Cr, and PGE2/Cr ratios were identified as potential biomarkers in female OAB patients. Results of the meta-analysis indicated that uNGF [standard mean difference (SMD) 1.45, 95% CI 0.53-2.36], NGF/Cr ratio (SMD 1.23, 95% CI 0.67-1.78), BDNF/Cr ratio (SMD 0.78, 95% CI 0.006-1.50), and BDNF/Cr ratio (RR 0.78, 95% CI 0.006-1.50) were increased in female OAB patients compared to healthy controls, whereas no difference was found for the PGE2/Cr and ATP/Cr ratios. Current data are inadequate to assess any other potential biomarkers, such as urinary MDA, ATP, and cytokines, in the management of OAB in female patients.

CONCLUSIONS

uNGF, NGF/Cr, and BDNF/Cr ratio could be used in the assessment of female OAB patients. Further studies are needed to specify OAB urinary titer levels in OAB subgroups and healthy women and their potential as diagnostic and management tools in OAB women.

Authors+Show Affiliations

1st Department of Obstetrics and Gynecology, "Papageorgiou" General Hospital, Aristotle University of Thessaloniki, Ring Road, Nea Efkarpia, 56403, Thessaloniki, Greece.2nd Department of Urology, Papageorgiou Hospital and Centre for Study of Continence and Pelvic Floor Dysfunctions, Aristotle University of Thessaloniki, Thessaloniki, Greece.2nd Department of Obstetrics and Gynecology, "Hippokrateio" General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.1st Department of Obstetrics and Gynecology, "Papageorgiou" General Hospital, Aristotle University of Thessaloniki, Ring Road, Nea Efkarpia, 56403, Thessaloniki, Greece.1st Department of Obstetrics and Gynecology, "Papageorgiou" General Hospital, Aristotle University of Thessaloniki, Ring Road, Nea Efkarpia, 56403, Thessaloniki, Greece. themis.mikos@gmail.com.

Pub Type(s)

Journal Article
Meta-Analysis
Review
Systematic Review

Language

eng

PubMed ID

34363496

Citation

Tsiapakidou, Sofia, et al. "The Use of Urinary Biomarkers in the Diagnosis of Overactive Bladder in Female Patients. a Systematic Review and Meta-analysis." International Urogynecology Journal, vol. 32, no. 12, 2021, pp. 3143-3155.
Tsiapakidou S, Apostolidis A, Pantazis K, et al. The use of urinary biomarkers in the diagnosis of overactive bladder in female patients. A systematic review and meta-analysis. Int Urogynecol J. 2021;32(12):3143-3155.
Tsiapakidou, S., Apostolidis, A., Pantazis, K., Grimbizis, G. F., & Mikos, T. (2021). The use of urinary biomarkers in the diagnosis of overactive bladder in female patients. A systematic review and meta-analysis. International Urogynecology Journal, 32(12), 3143-3155. https://doi.org/10.1007/s00192-021-04945-1
Tsiapakidou S, et al. The Use of Urinary Biomarkers in the Diagnosis of Overactive Bladder in Female Patients. a Systematic Review and Meta-analysis. Int Urogynecol J. 2021;32(12):3143-3155. PubMed PMID: 34363496.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The use of urinary biomarkers in the diagnosis of overactive bladder in female patients. A systematic review and meta-analysis. AU - Tsiapakidou,Sofia, AU - Apostolidis,Apostolos, AU - Pantazis,Konstantinos, AU - Grimbizis,Grigoris F, AU - Mikos,Themistoklis, Y1 - 2021/08/07/ PY - 2021/04/15/received PY - 2021/07/18/accepted PY - 2021/8/8/pubmed PY - 2021/12/15/medline PY - 2021/8/7/entrez KW - BDNF KW - Biomarker KW - Brain-derived neurotrophic factor KW - NGF KW - Nerve growth factor KW - OAB KW - Overactive bladder SP - 3143 EP - 3155 JF - International urogynecology journal JO - Int Urogynecol J VL - 32 IS - 12 N2 - INTRODUCTION AND HYPOTHESIS: Nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and other proteins are related to overactive bladder (OAB) syndrome, as their urinary concentrations are significantly different from those of the general non-OAB population. This review aims to systematically assess whether NGF, BDNF, and other urinary by-products can be used as potential biomarkers to manage women with OAB. METHODS: This was a systematic review and metanalysis that was conducted according to PRISMA guidelines. Studies were identified by electronic search of Medline, Scopus, ScienceDirect, Embase, and Cochrane Register until October 2020. The included studies investigated the correlation of OAB with NGF, BDNF, and other potential biomarkers in symptomatic women and their controls. RESULTS: Twelve studies (581 female OAB patients and 394 female controls) were included. Urinary NGF, NGF/Cr, BDNF/Cr, ATP/Cr, and PGE2/Cr ratios were identified as potential biomarkers in female OAB patients. Results of the meta-analysis indicated that uNGF [standard mean difference (SMD) 1.45, 95% CI 0.53-2.36], NGF/Cr ratio (SMD 1.23, 95% CI 0.67-1.78), BDNF/Cr ratio (SMD 0.78, 95% CI 0.006-1.50), and BDNF/Cr ratio (RR 0.78, 95% CI 0.006-1.50) were increased in female OAB patients compared to healthy controls, whereas no difference was found for the PGE2/Cr and ATP/Cr ratios. Current data are inadequate to assess any other potential biomarkers, such as urinary MDA, ATP, and cytokines, in the management of OAB in female patients. CONCLUSIONS: uNGF, NGF/Cr, and BDNF/Cr ratio could be used in the assessment of female OAB patients. Further studies are needed to specify OAB urinary titer levels in OAB subgroups and healthy women and their potential as diagnostic and management tools in OAB women. SN - 1433-3023 UR - https://www.unboundmedicine.com/medline/citation/34363496/The_use_of_urinary_biomarkers_in_the_diagnosis_of_overactive_bladder_in_female_patients__A_systematic_review_and_meta_analysis_ L2 - https://dx.doi.org/10.1007/s00192-021-04945-1 DB - PRIME DP - Unbound Medicine ER -