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Paricalcitol versus Calcitriol + Cinacalcet for the Treatment of Secondary Hyperparathyroidism in Chronic Kidney Disease in China: A Cost-Effectiveness Analysis.
Front Public Health. 2021; 9:712027.FP

Abstract

Background: Chronic Kidney Disease (CKD) is a global chronic disease with increasing prevalence in recent years, particularly CKD accompanied by Secondary Hyperparathyroidism (SHPT) leads to reduced quality of life, increased mortality, a considerable economic burden for patients and society. The aim of this study was to investigate the cost-effectiveness analysis of paricalcitol vs. calcitriol + cinacalcet for CKD patients with SHPT in China in 2020. Methods: A Markov model was conducted employing data derived from published literature, clinical trials, official sources, and tertiary public hospital data in China, based on a 10-year horizon from the perspective of the healthcare system. Calcitriol + Cinacalcet was used as the reference group. CKD stage 5 (CKD-5) dialysis patients suffering from SHPT were included in the study. Effectiveness was measured in quality-adjusted life years (QALYs). The discount rate (5%) was applied to costs and effectiveness. Sensitivity analysis was performed to confirm the robustness of the findings. Results: The base case analysis demonstrated that Patients treated with paricalcitol could gain an increase in utility (0.183 QALYs) and require fewer expenditures (6925.612 yuan). One-way sensitivity analysis was performed to showed that impact factors were the price of cinacalcet, the hospitalization costs of patients with paricalcitol and calcitriol, the costs and utilities of hemodialysis and the costs of calcitriol, the costs of paricalcitol regardless of period. Probabilistic simulation analysis displayed when willingness-to-pay was ¥217113, the probability that Paricalcitol was dominant is 96.20%. Conclusion: The results showed that paricalcitol administrated to treat patients diagnosed with Secondary hyperparathyroidism in Chronic Kidney Disease, compared to calcitriol and cinacalcet, might be dominant in China.

Authors+Show Affiliations

Department of Clinical Pharmacy, School of Pharmacy, Nanjing Medical University, Nanjing, China.Department of Clinical Pharmacy, School of Pharmacy, Nanjing Medical University, Nanjing, China.Department of Clinical Pharmacy, School of Pharmacy, Nanjing Medical University, Nanjing, China. Department of Pharmacy, Lianyungang Second People's Hospital, Lianyungang, China.Department of Clinical Pharmacy, School of Pharmacy, Nanjing Medical University, Nanjing, China.Department of Health Policy, School of Health Policy and Management, Nanjing Medical University, Nanjing, China.Department of Health Policy, School of Health Policy and Management, Nanjing Medical University, Nanjing, China.Department of Health Policy, School of Health Policy and Management, Nanjing Medical University, Nanjing, China.Department of Clinical Pharmacy, School of Pharmacy, Nanjing Medical University, Nanjing, China. Department of Health Policy, School of Health Policy and Management, Nanjing Medical University, Nanjing, China. Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

34368073

Citation

Zhang, Zhuolin, et al. "Paricalcitol Versus Calcitriol + Cinacalcet for the Treatment of Secondary Hyperparathyroidism in Chronic Kidney Disease in China: a Cost-Effectiveness Analysis." Frontiers in Public Health, vol. 9, 2021, p. 712027.
Zhang Z, Cai L, Wu H, et al. Paricalcitol versus Calcitriol + Cinacalcet for the Treatment of Secondary Hyperparathyroidism in Chronic Kidney Disease in China: A Cost-Effectiveness Analysis. Front Public Health. 2021;9:712027.
Zhang, Z., Cai, L., Wu, H., Xu, X., Fang, W., He, X., Wang, X., & Li, X. (2021). Paricalcitol versus Calcitriol + Cinacalcet for the Treatment of Secondary Hyperparathyroidism in Chronic Kidney Disease in China: A Cost-Effectiveness Analysis. Frontiers in Public Health, 9, 712027. https://doi.org/10.3389/fpubh.2021.712027
Zhang Z, et al. Paricalcitol Versus Calcitriol + Cinacalcet for the Treatment of Secondary Hyperparathyroidism in Chronic Kidney Disease in China: a Cost-Effectiveness Analysis. Front Public Health. 2021;9:712027. PubMed PMID: 34368073.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Paricalcitol versus Calcitriol + Cinacalcet for the Treatment of Secondary Hyperparathyroidism in Chronic Kidney Disease in China: A Cost-Effectiveness Analysis. AU - Zhang,Zhuolin, AU - Cai,Lele, AU - Wu,Hong, AU - Xu,Xinglu, AU - Fang,Wenqing, AU - He,Xuan, AU - Wang,Xiao, AU - Li,Xin, Y1 - 2021/07/21/ PY - 2021/05/19/received PY - 2021/06/25/accepted PY - 2021/8/9/entrez PY - 2021/8/10/pubmed PY - 2021/8/12/medline KW - calcitriol KW - chronic kidney disease KW - cinacalcet KW - cost-effectiveness analysis KW - paricalcitol KW - secondary hyperparathyroidism SP - 712027 EP - 712027 JF - Frontiers in public health JO - Front Public Health VL - 9 N2 - Background: Chronic Kidney Disease (CKD) is a global chronic disease with increasing prevalence in recent years, particularly CKD accompanied by Secondary Hyperparathyroidism (SHPT) leads to reduced quality of life, increased mortality, a considerable economic burden for patients and society. The aim of this study was to investigate the cost-effectiveness analysis of paricalcitol vs. calcitriol + cinacalcet for CKD patients with SHPT in China in 2020. Methods: A Markov model was conducted employing data derived from published literature, clinical trials, official sources, and tertiary public hospital data in China, based on a 10-year horizon from the perspective of the healthcare system. Calcitriol + Cinacalcet was used as the reference group. CKD stage 5 (CKD-5) dialysis patients suffering from SHPT were included in the study. Effectiveness was measured in quality-adjusted life years (QALYs). The discount rate (5%) was applied to costs and effectiveness. Sensitivity analysis was performed to confirm the robustness of the findings. Results: The base case analysis demonstrated that Patients treated with paricalcitol could gain an increase in utility (0.183 QALYs) and require fewer expenditures (6925.612 yuan). One-way sensitivity analysis was performed to showed that impact factors were the price of cinacalcet, the hospitalization costs of patients with paricalcitol and calcitriol, the costs and utilities of hemodialysis and the costs of calcitriol, the costs of paricalcitol regardless of period. Probabilistic simulation analysis displayed when willingness-to-pay was ¥217113, the probability that Paricalcitol was dominant is 96.20%. Conclusion: The results showed that paricalcitol administrated to treat patients diagnosed with Secondary hyperparathyroidism in Chronic Kidney Disease, compared to calcitriol and cinacalcet, might be dominant in China. SN - 2296-2565 UR - https://www.unboundmedicine.com/medline/citation/34368073/Paricalcitol_versus_Calcitriol_+_Cinacalcet_for_the_Treatment_of_Secondary_Hyperparathyroidism_in_Chronic_Kidney_Disease_in_China:_A_Cost_Effectiveness_Analysis_ L2 - https://doi.org/10.3389/fpubh.2021.712027 DB - PRIME DP - Unbound Medicine ER -