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Hyperhydration with glycerol solutions.
J Appl Physiol (1985). 1987 Dec; 63(6):2262-8.JA

Abstract

Glycerol was tested as an agent to promote hyperhydration of male and female subjects. Series I experiments involved ingesting 0.5, 1.0, or 1.5 g glycerol/kg body wt and within 40 min drinking 0.1% NaCl, 21.4 ml/kg. In series II, 1.0 g glycerol/kg body wt was ingested at time 0, and 25.7 ml/kg of 0.1% NaCl was ingested over a 3.5-h period. Experiments were of 4-h duration and included controls without glycerol as each subject served as his/her control. Blood samples were taken at 40- or 60-min intervals for hemoglobin (Hb), hematocrit (Hct), plasma osmolality, glycerol, and multiple blood chemistry analyses. Urine was collected at 60-min intervals. Glycerol ingestion increased plasma osmolality for 2 h and reduced the total 4-h urine volume. There were no significant changes in Hb or Hct as a result of the glycerol or excess fluid intake. This study demonstrates that glycerol plus excess fluid intake can produce hyperhydration for at least 4 h.

Authors+Show Affiliations

Department of Biology, University of New Mexico, Albuquerque 87131.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

3436862

Citation

Riedesel, M L., et al. "Hyperhydration With Glycerol Solutions." Journal of Applied Physiology (Bethesda, Md. : 1985), vol. 63, no. 6, 1987, pp. 2262-8.
Riedesel ML, Allen DY, Peake GT, et al. Hyperhydration with glycerol solutions. J Appl Physiol. 1987;63(6):2262-8.
Riedesel, M. L., Allen, D. Y., Peake, G. T., & Al-Qattan, K. (1987). Hyperhydration with glycerol solutions. Journal of Applied Physiology (Bethesda, Md. : 1985), 63(6), 2262-8.
Riedesel ML, et al. Hyperhydration With Glycerol Solutions. J Appl Physiol. 1987;63(6):2262-8. PubMed PMID: 3436862.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hyperhydration with glycerol solutions. AU - Riedesel,M L, AU - Allen,D Y, AU - Peake,G T, AU - Al-Qattan,K, PY - 1987/12/1/pubmed PY - 1987/12/1/medline PY - 1987/12/1/entrez SP - 2262 EP - 8 JF - Journal of applied physiology (Bethesda, Md. : 1985) JO - J. Appl. Physiol. VL - 63 IS - 6 N2 - Glycerol was tested as an agent to promote hyperhydration of male and female subjects. Series I experiments involved ingesting 0.5, 1.0, or 1.5 g glycerol/kg body wt and within 40 min drinking 0.1% NaCl, 21.4 ml/kg. In series II, 1.0 g glycerol/kg body wt was ingested at time 0, and 25.7 ml/kg of 0.1% NaCl was ingested over a 3.5-h period. Experiments were of 4-h duration and included controls without glycerol as each subject served as his/her control. Blood samples were taken at 40- or 60-min intervals for hemoglobin (Hb), hematocrit (Hct), plasma osmolality, glycerol, and multiple blood chemistry analyses. Urine was collected at 60-min intervals. Glycerol ingestion increased plasma osmolality for 2 h and reduced the total 4-h urine volume. There were no significant changes in Hb or Hct as a result of the glycerol or excess fluid intake. This study demonstrates that glycerol plus excess fluid intake can produce hyperhydration for at least 4 h. SN - 8750-7587 UR - https://www.unboundmedicine.com/medline/citation/3436862/Hyperhydration_with_glycerol_solutions_ L2 - http://journals.physiology.org/doi/full/10.1152/jappl.1987.63.6.2262?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -