Tags

Type your tag names separated by a space and hit enter

Effects of Folic Acid Supplementation on Inflammatory Markers: A Grade-Assessed Systematic Review and Dose-Response Meta-Analysis of Randomized Controlled Trials.
Nutrients. 2021 Jul 06; 13(7)N

Abstract

It has been theorized that folic acid supplementation improves inflammation. However, its proven effects on inflammatory markers are unclear as clinical studies on this topic have produced inconsistent results. To bridge this knowledge gap, this systematic review and meta-analysis of randomized controlled trials (RCTs) aimed to evaluate the effects of folic acid supplementation on serum concentrations of the inflammatory markers C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α). Methods: To identify eligible RCTs, a systematic search up to April 2021 was completed in PubMed/Medline, Scopus, Web of Science, EMBASE, Cochrane databases, and Google Scholar using relevant keywords. A fix or random-effects model was utilized to estimate the weighted mean difference (WMD) and 95% confidence interval (95% CI). Results: Twelve RCTs were included in the present meta-analysis. The pooled analysis revealed that serum concentrations of CRP (WMD: -0.59 mg/L, 95% CI -0.85 to -0.33, p < 0.001) were significantly reduced following folic acid supplementation compared to placebo, but did not affect serum concentrations of IL-6 (WMD: -0.12, 95% CI -0.95 to 0.72 pg/mL, p = 0.780) or TNF-α (WMD: -0.18, 95% CI -0.86 to 0.49 pg/mL, p = 0.594). The dose-response analysis demonstrated a significant relationship between an elevated dosage of folic acid supplementation and lower CRP concentrations (p = 0.002). Conclusions: We found that folic acid supplementation may improve inflammation by attenuating serum concentrations of CRP but without significant effects on IL-6 and TNF-α. Future RCTs including a larger number of participants and more diverse populations are needed to confirm and expand our findings.

Authors+Show Affiliations

Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran 14167-53955, Iran.Nutrition and Metabolic Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz 61357-15794, Iran.Department of Exercise Physiology, University of Isfahan, Isfahan 81746-73441, Iran.Department of Clinical Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan 81746-73461, Iran.Student Research Committee, Lorestan University of Medical Sciences, Khorramabad 68138-33946, Iran.Department of Clinical Laboratory Sciences, Faculty of Allied Medicine, Tehran University of Medical Sciences, Tehran 14176-13151, Iran.Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan 81746-73461, Iran.Department of Health and Human Performance, Marymount University, Arlington, VA 22207, USA.CNRS, LaPSCo, Physiological and Psychosocial Stress, CHU Clermont-Ferrand, University Hospital of Clermont-Ferrand, Preventive and Occupational Medicine, Université Clermont Auvergne, WittyFit, F-63000 Clermont-Ferrand, France.Faculty of Sport Sciences, Waseda University, 2-579-15 Mikajima, Tokorozawa 359-1192, Japan.Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan 81746-73461, Iran.

Pub Type(s)

Journal Article
Meta-Analysis
Systematic Review

Language

eng

PubMed ID

34371837

Citation

Asbaghi, Omid, et al. "Effects of Folic Acid Supplementation On Inflammatory Markers: a Grade-Assessed Systematic Review and Dose-Response Meta-Analysis of Randomized Controlled Trials." Nutrients, vol. 13, no. 7, 2021.
Asbaghi O, Ashtary-Larky D, Bagheri R, et al. Effects of Folic Acid Supplementation on Inflammatory Markers: A Grade-Assessed Systematic Review and Dose-Response Meta-Analysis of Randomized Controlled Trials. Nutrients. 2021;13(7).
Asbaghi, O., Ashtary-Larky, D., Bagheri, R., Moosavian, S. P., Nazarian, B., Afrisham, R., Kelishadi, M. R., Wong, A., Dutheil, F., Suzuki, K., & Alavi Naeini, A. (2021). Effects of Folic Acid Supplementation on Inflammatory Markers: A Grade-Assessed Systematic Review and Dose-Response Meta-Analysis of Randomized Controlled Trials. Nutrients, 13(7). https://doi.org/10.3390/nu13072327
Asbaghi O, et al. Effects of Folic Acid Supplementation On Inflammatory Markers: a Grade-Assessed Systematic Review and Dose-Response Meta-Analysis of Randomized Controlled Trials. Nutrients. 2021 Jul 6;13(7) PubMed PMID: 34371837.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of Folic Acid Supplementation on Inflammatory Markers: A Grade-Assessed Systematic Review and Dose-Response Meta-Analysis of Randomized Controlled Trials. AU - Asbaghi,Omid, AU - Ashtary-Larky,Damoon, AU - Bagheri,Reza, AU - Moosavian,Seyedeh Parisa, AU - Nazarian,Behzad, AU - Afrisham,Reza, AU - Kelishadi,Mahnaz Rezaei, AU - Wong,Alexei, AU - Dutheil,Frédéric, AU - Suzuki,Katsuhiko, AU - Alavi Naeini,Amirmansour, Y1 - 2021/07/06/ PY - 2021/06/11/received PY - 2021/06/29/revised PY - 2021/07/02/accepted PY - 2021/8/10/entrez PY - 2021/8/11/pubmed PY - 2021/9/10/medline KW - folic acid KW - inflammation KW - metabolic diseases JF - Nutrients JO - Nutrients VL - 13 IS - 7 N2 - It has been theorized that folic acid supplementation improves inflammation. However, its proven effects on inflammatory markers are unclear as clinical studies on this topic have produced inconsistent results. To bridge this knowledge gap, this systematic review and meta-analysis of randomized controlled trials (RCTs) aimed to evaluate the effects of folic acid supplementation on serum concentrations of the inflammatory markers C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α). Methods: To identify eligible RCTs, a systematic search up to April 2021 was completed in PubMed/Medline, Scopus, Web of Science, EMBASE, Cochrane databases, and Google Scholar using relevant keywords. A fix or random-effects model was utilized to estimate the weighted mean difference (WMD) and 95% confidence interval (95% CI). Results: Twelve RCTs were included in the present meta-analysis. The pooled analysis revealed that serum concentrations of CRP (WMD: -0.59 mg/L, 95% CI -0.85 to -0.33, p < 0.001) were significantly reduced following folic acid supplementation compared to placebo, but did not affect serum concentrations of IL-6 (WMD: -0.12, 95% CI -0.95 to 0.72 pg/mL, p = 0.780) or TNF-α (WMD: -0.18, 95% CI -0.86 to 0.49 pg/mL, p = 0.594). The dose-response analysis demonstrated a significant relationship between an elevated dosage of folic acid supplementation and lower CRP concentrations (p = 0.002). Conclusions: We found that folic acid supplementation may improve inflammation by attenuating serum concentrations of CRP but without significant effects on IL-6 and TNF-α. Future RCTs including a larger number of participants and more diverse populations are needed to confirm and expand our findings. SN - 2072-6643 UR - https://www.unboundmedicine.com/medline/citation/34371837/Effects_of_Folic_Acid_Supplementation_on_Inflammatory_Markers:_A_Grade_Assessed_Systematic_Review_and_Dose_Response_Meta_Analysis_of_Randomized_Controlled_Trials_ DB - PRIME DP - Unbound Medicine ER -