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Genetic and Chemical Capsid Modifications of Adenovirus Vectors to Modulate Vector-Host Interactions.
Viruses. 2021 07 02; 13(7)V

Abstract

Adenovirus-based vectors are playing an important role as efficacious genetic vaccines to fight the current COVID-19 pandemic. Furthermore, they have an enormous potential as oncolytic vectors for virotherapy and as vectors for classic gene therapy. However, numerous vector-host interactions on a cellular and noncellular level, including specific components of the immune system, must be modulated in order to generate safe and efficacious vectors for virotherapy or classic gene therapy. Importantly, the current widespread use of Ad vectors as vaccines against COVID-19 will induce antivector immunity in many humans. This requires the development of strategies and techniques to enable Ad-based vectors to evade pre-existing immunity. In this review article, we discuss the current status of genetic and chemical capsid modifications as means to modulate the vector-host interactions of Ad-based vectors.

Authors+Show Affiliations

Chair of Biochemistry and Molecular Medicine, Center for Biomedical Education and Research (ZBAF), Witten/Herdecke University, Stockumer Street 10, 58453 Witten, Germany.Chair of Biochemistry and Molecular Medicine, Center for Biomedical Education and Research (ZBAF), Witten/Herdecke University, Stockumer Street 10, 58453 Witten, Germany.Chair of Biochemistry and Molecular Medicine, Center for Biomedical Education and Research (ZBAF), Witten/Herdecke University, Stockumer Street 10, 58453 Witten, Germany.Chair of Biochemistry and Molecular Medicine, Center for Biomedical Education and Research (ZBAF), Witten/Herdecke University, Stockumer Street 10, 58453 Witten, Germany.Chair of Biochemistry and Molecular Medicine, Center for Biomedical Education and Research (ZBAF), Witten/Herdecke University, Stockumer Street 10, 58453 Witten, Germany.Chair of Biochemistry and Molecular Medicine, Center for Biomedical Education and Research (ZBAF), Witten/Herdecke University, Stockumer Street 10, 58453 Witten, Germany.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

34372506

Citation

Weklak, Denice, et al. "Genetic and Chemical Capsid Modifications of Adenovirus Vectors to Modulate Vector-Host Interactions." Viruses, vol. 13, no. 7, 2021.
Weklak D, Pembaur D, Koukou G, et al. Genetic and Chemical Capsid Modifications of Adenovirus Vectors to Modulate Vector-Host Interactions. Viruses. 2021;13(7).
Weklak, D., Pembaur, D., Koukou, G., Jönsson, F., Hagedorn, C., & Kreppel, F. (2021). Genetic and Chemical Capsid Modifications of Adenovirus Vectors to Modulate Vector-Host Interactions. Viruses, 13(7). https://doi.org/10.3390/v13071300
Weklak D, et al. Genetic and Chemical Capsid Modifications of Adenovirus Vectors to Modulate Vector-Host Interactions. Viruses. 2021 07 2;13(7) PubMed PMID: 34372506.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Genetic and Chemical Capsid Modifications of Adenovirus Vectors to Modulate Vector-Host Interactions. AU - Weklak,Denice, AU - Pembaur,Daniel, AU - Koukou,Georgia, AU - Jönsson,Franziska, AU - Hagedorn,Claudia, AU - Kreppel,Florian, Y1 - 2021/07/02/ PY - 2021/05/26/received PY - 2021/06/25/revised PY - 2021/06/27/accepted PY - 2021/8/10/entrez PY - 2021/8/11/pubmed PY - 2021/8/31/medline KW - COVID-19 vaccine KW - HPMA KW - PEGylation KW - adenovirus KW - capsid modification KW - chemical modification JF - Viruses JO - Viruses VL - 13 IS - 7 N2 - Adenovirus-based vectors are playing an important role as efficacious genetic vaccines to fight the current COVID-19 pandemic. Furthermore, they have an enormous potential as oncolytic vectors for virotherapy and as vectors for classic gene therapy. However, numerous vector-host interactions on a cellular and noncellular level, including specific components of the immune system, must be modulated in order to generate safe and efficacious vectors for virotherapy or classic gene therapy. Importantly, the current widespread use of Ad vectors as vaccines against COVID-19 will induce antivector immunity in many humans. This requires the development of strategies and techniques to enable Ad-based vectors to evade pre-existing immunity. In this review article, we discuss the current status of genetic and chemical capsid modifications as means to modulate the vector-host interactions of Ad-based vectors. SN - 1999-4915 UR - https://www.unboundmedicine.com/medline/citation/34372506/Genetic_and_Chemical_Capsid_Modifications_of_Adenovirus_Vectors_to_Modulate_Vector_Host_Interactions_ L2 - https://www.mdpi.com/resolver?pii=v13071300 DB - PRIME DP - Unbound Medicine ER -