Tags

Type your tag names separated by a space and hit enter

A single-center experience with giant cell tumors of sphenoid bone and clivus.
Tumori. 2021 Dec; 107(6):NP94-NP100.T

Abstract

OBJECTIVE

To present pathologic, clinical, and treatment findings for giant cell tumors (GCTs) of sphenoid bone and clivus.

METHODS

We describe the optimal treatment algorithm in patients with a histopathologic diagnosis of bone GCT by presenting the effects of denosumab treatment in both pediatric and adult patients with GCT undergoing endoscopic transnasal surgery. Clinicopathologic correlation is crucial for the differential diagnosis of GCT and the choice of treatment modality.

CONCLUSION

GCT of bone is a local aggressive tumor that accounts for about 3%-7% of all bone tumors. GCTs located in the cranium are extremely uncommon neoplasms. There are no defined guidelines for the treatment of GCTs in skull base. Following surgical resection of the tumor, the addition of denosumab treatments to radiotherapy has a significant role in preventing the recurrence of GCT and in promoting regression of residual tumor size.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Yaprak Bayrak B
Department of Pathology, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey.
Özcan E
Department of Pathology, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey.
Vural Ç
Department of Pathology, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey.
Emengen A
Department of Neurosurgery, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey.
Çabuk B
Department of Neurosurgery, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey.
Ceylan S
Department of Neurosurgery, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey.

MeSH

AdolescentAdultBiopsyBone NeoplasmsChildClinical Decision-MakingCombined Modality TherapyCranial Fossa, PosteriorDiagnosis, DifferentialDisease ManagementFemaleGiant Cell TumorsHistocytochemistryHumansMagnetic Resonance ImagingMaleSphenoid BoneSymptom AssessmentTomography, X-Ray ComputedYoung Adult

Pub Type(s)

Journal Article

Language

eng

PubMed ID

34374310

Citation

Yaprak Bayrak, Büşra, et al. "A Single-center Experience With Giant Cell Tumors of Sphenoid Bone and Clivus." Tumori, vol. 107, no. 6, 2021, pp. NP94-NP100.
Yaprak Bayrak B, Özcan E, Vural Ç, et al. A single-center experience with giant cell tumors of sphenoid bone and clivus. Tumori. 2021;107(6):NP94-NP100.
Yaprak Bayrak, B., Özcan, E., Vural, Ç., Emengen, A., Çabuk, B., & Ceylan, S. (2021). A single-center experience with giant cell tumors of sphenoid bone and clivus. Tumori, 107(6), NP94-NP100. https://doi.org/10.1177/03008916211024357
Yaprak Bayrak B, et al. A Single-center Experience With Giant Cell Tumors of Sphenoid Bone and Clivus. Tumori. 2021;107(6):NP94-NP100. PubMed PMID: 34374310.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A single-center experience with giant cell tumors of sphenoid bone and clivus. AU - Yaprak Bayrak,Büşra, AU - Özcan,Emre, AU - Vural,Çiğdem, AU - Emengen,Atakan, AU - Çabuk,Burak, AU - Ceylan,Savaş, Y1 - 2021/08/10/ PY - 2021/8/11/pubmed PY - 2021/12/15/medline PY - 2021/8/10/entrez KW - Cranium KW - denosumab KW - endoscopic transnasal surgery KW - giant cell tumor SP - NP94 EP - NP100 JF - Tumori JO - Tumori VL - 107 IS - 6 N2 - OBJECTIVE: To present pathologic, clinical, and treatment findings for giant cell tumors (GCTs) of sphenoid bone and clivus. METHODS: We describe the optimal treatment algorithm in patients with a histopathologic diagnosis of bone GCT by presenting the effects of denosumab treatment in both pediatric and adult patients with GCT undergoing endoscopic transnasal surgery. Clinicopathologic correlation is crucial for the differential diagnosis of GCT and the choice of treatment modality. CONCLUSION: GCT of bone is a local aggressive tumor that accounts for about 3%-7% of all bone tumors. GCTs located in the cranium are extremely uncommon neoplasms. There are no defined guidelines for the treatment of GCTs in skull base. Following surgical resection of the tumor, the addition of denosumab treatments to radiotherapy has a significant role in preventing the recurrence of GCT and in promoting regression of residual tumor size. SN - 2038-2529 UR - https://www.unboundmedicine.com/medline/citation/34374310/A_single_center_experience_with_giant_cell_tumors_of_sphenoid_bone_and_clivus_ DB - PRIME DP - Unbound Medicine ER -